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ClinicalTrials.gov 15 recruiting now official registry

Primary Myelofibrosis clinical trials

15 of 31 indexed Primary Myelofibrosis trials are currently recruiting.

31 US clinical trials · 15 currently recruiting

Primary Myelofibrosis is the subject of 31 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 25 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 5 of these trials.

The research picture

Primary Myelofibrosis has 31 registered US clinical trials, 15 of them open to new participants right now, about 48% of the total.

15
recruiting participants now
48%
of trials open to enrollment
6
in Phase 3–4 (later-stage)
5
top sponsor: M.D. Anderson Cancer Center
Phase 19Phase 216Phase 36

Active & Recent Trials

31 total, page 1 of 1

RECRUITING Phase 3 600 participants

Study of Navtemadlin add-on to Ruxolitinib in JAK Inhibitor-Naïve Patients With Myelofibrosis Who Have a Suboptimal Response to Ruxolitinib

Kartos Therapeutics

NCT06479135

RECRUITING Phase 3 400 participants

A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017)

Merck Sharp & Dohme

NCT06351631

RECRUITING Phase 3 399 participants

A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis

Swedish Orphan Biovitrum

NCT03165734

RECRUITING Phase 1 150 participants

Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia

Disc Medicine

NCT05320198

RECRUITING Phase 1 76 participants

A Phase 1 Study of AJ1-11095 in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), or Post-Essential Thrombocythemia Myelofibrosis (PET-MF) Who Have Been Failed by a Type I JAK2 Inhibitor (JAK2i)

Ajax Therapeutics

NCT06343805

RECRUITING Phase 1 70 participants

Study of TL-895 Combined With Ruxolitinib in JAKi Treatment-Naïve MF Subjects and Subjects With MF Who Have a Suboptimal Response to Ruxolitinib

Telios Pharma

NCT05280509

RECRUITING Phase 2 62 participants

A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs)

National Cancer Institute (NCI)

NCT06661915

RECRUITING Phase 2 56 participants

Study of Momelotinib in Combination With Luspatercept in Participants With Transfusion Dependent Myelofibrosis

GlaxoSmithKline

NCT06517875

RECRUITING Phase 1 50 participants

UAB 2419-CD34 Selection Using the Automated CliniMACS Prodigy

University of Alabama at Birmingham

NCT06047886

RECRUITING Phase 2 50 participants

Ruxolitinib Before, During and After Hematopoietic Cell Transplant in Older Patients With Myelofibrosis and Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes

Fred Hutchinson Cancer Center

NCT07228624

RECRUITING Phase 1 33 participants

Open Label Phase 1/2 Study of Tasquinimod in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (Post-PV MF), or Post-Essential Thrombocytosis Myelofibrosis (Post-ET MF)

M.D. Anderson Cancer Center

NCT06327100

RECRUITING Phase 2 25 participants

Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms

University of Washington

NCT04282187

RECRUITING Phase 1 24 participants

Pacritinib w/ Talazoparib in Pts w/ Myeloproliferative Neoplasms Unresponsive to JAK2 Inhibition

Fox Chase Cancer Center

NCT06218628

RECRUITING Phase 2 20 participants

Reduced Intensity Haploidentical Transplantation for the Treatment of Primary or Secondary Myelofibrosis

Fred Hutchinson Cancer Center

NCT04370301

RECRUITING Phase 2 14 participants

Study of Canakinumab in Patients With Myelofibrosis

John Mascarenhas

NCT05467800

ACTIVE NOT RECRUITING Phase 3 430 participants

Phase 3 Study of Pelabresib (CPI-0610) in Myelofibrosis (MF) (MANIFEST-2)

Novartis Pharmaceuticals

NCT04603495

ACTIVE NOT RECRUITING Phase 3 313 participants

An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK2 Inhibitor Therapy and Who Require Red Blood Cell Transfusions

Celgene

NCT04717414

ACTIVE NOT RECRUITING Phase 2 121 participants

Ruxolitinib Phosphate and Azacytidine in Treating Patients With Myelofibrosis or Myelodysplastic Syndrome/Myeloproliferative Neoplasm

M.D. Anderson Cancer Center

NCT01787487

ACTIVE NOT RECRUITING Phase 2 61 participants

JAK Inhibitor Before Donor Stem Cell Transplant in Treating Patients With Primary or Secondary Myelofibrosis

Fred Hutchinson Cancer Center

NCT02251821

ACTIVE NOT RECRUITING Phase 2 59 participants

Itacitinib, Tacrolimus, and Sirolimus for the Prevention of GVHD in Patients With Acute Leukemia, Myelodysplastic Syndrome, or Myelofibrosis Undergoing Reduced Intensity Conditioning Donor Stem Cell Transplantation

City of Hope Medical Center

NCT04339101

ACTIVE NOT RECRUITING Phase 2 53 participants

Peritransplant Ruxolitinib for Patients With Primary and Secondary Myelofibrosis

Fred Hutchinson Cancer Center

NCT04384692

ACTIVE NOT RECRUITING Phase 2 21 participants

Decitabine in Treating Patients With Myelofibrosis

National Cancer Institute (NCI)

NCT00095784

ACTIVE NOT RECRUITING Phase 2 20 participants

Adding Itacitinib to Cyclophosphamide and Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Hematopoietic Stem Cell Transplants

City of Hope Medical Center

NCT05364762

ACTIVE NOT RECRUITING Phase 2 15 participants

Elotuzumab for the Treatment of JAK2-Mutated Myelofibrosis

M.D. Anderson Cancer Center

NCT04517851

COMPLETED Phase 3 267 participants

Study of Pomalidomide in Persons With Myeloproliferative-Neoplasm-Associated Myelofibrosis and RBC-Transfusion-Dependence

Celgene

NCT01178281

COMPLETED Phase 2 80 participants

Imetelstat Sodium in Treating Participants With Primary or Secondary Myelofibrosis

Geron Corporation

NCT01731951

COMPLETED Phase 1 77 participants

Safety and Tolerability Study of Oral NS-018 in Patients With Primary Myelofibrosis (MF), Post-polycythemia Vera MF or Post-essential Thrombocythemia MF

NS Pharma

NCT01423851

COMPLETED Phase 2 35 participants

Tipifarnib in Treating Patients With Myelofibrosis and Myeloid Metaplasia

National Cancer Institute (NCI)

NCT00047190

COMPLETED Phase 2 21 participants

Eltrombopag Olamine in Treating Thrombocytopenia in Patients With Chronic Myeloid Leukemia or Myelofibrosis Receiving Tyrosine Kinase Therapy

M.D. Anderson Cancer Center

NCT01428635

COMPLETED Phase 1 21 participants

MPN-RC 118 AVID200 in Myelofibrosis

John Mascarenhas

NCT03895112

COMPLETED Early Phase 1 3 participants

Combination Chemotherapy, Total Body Irradiation, and Donor Blood Stem Cell Transplant in Treating Patients With Primary or Secondary Myelofibrosis

M.D. Anderson Cancer Center

NCT03426969

Phase Distribution

PhaseTrial count
Phase 1 9
Phase 2 16
Phase 3 6

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Primary Myelofibrosis Trial Landscape

31 indexed Primary Myelofibrosis studies · 15 recruiting (48%).

Phase mix: 6 late (III/IV) vs 25 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (5 trials), 9 others listed. 31 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Primary Myelofibrosis?

PlainTrial tracks 31 US clinical trials for Primary Myelofibrosis, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Primary Myelofibrosis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.