Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Prader-Willi Syndrome: early-phase trial registry
7 of 17 indexed Prader-Willi Syndrome trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #1,004 of 28,707 conditions by registered trial count.
17 US clinical trials · 7 currently recruiting · #1,004 of 28,707 conditions by registered trial count
Prader-Willi Syndrome: 17 US clinical trials tracked, 7 recruiting.
Prader-Willi Syndrome is the subject of 17 registered US clinical trials on ClinicalTrials.gov, 7 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is Harmony Biosciences Management, running 2 of these trials.
Enrollment posture brief
Registry condition prader-willi-syndrome
OPEN 7 | RECR 41% | LATE 5 | EARLY 8 | RANK #1004 | SPON 2
Volume-matched condition peers
Nearest open-share peer: Erectile Dysfunction (41% recruiting · 34 trials)
Prader-Willi Syndrome lists 7 open slots (41% of 17 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Prader-Willi Syndrome on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Prader-Willi Syndrome is recruiting below its size-band peers.
7 of 17 indexed trials (41.2%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Prader-Willi Syndrome trials is spread across many organizations.
Harmony Biosciences Management accounts for 2 of 17 trials (11.8%). 14 distinct sponsors appear on at least one study for this condition label.
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Most Prader-Willi Syndrome trials plan to enrol fewer than 100 people.
Median target enrolment is 30 among the 17 trials that report a genuine target (sentinel values excluded). 13 of those (76.5%) plan for fewer than 100 participants.
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Prader-Willi Syndrome research is mostly interventional.
17 interventional and 0 observational studies make up this index (100% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
17 total, page 1 of 1
Physical Activity and Community EmPOWERment Project
University of North Carolina, Chapel Hill
NCT06740162
A Study of RM-718 in Healthy Subjects and Patients With MC4R Pathway Impairment
Rhythm Pharmaceuticals
NCT06239116
A Study of Pitolisant in Patients With Prader-Willi Syndrome
Harmony Biosciences Management
NCT06366464
A Clinical Evaluation of Non-Invasive Vagus Nerve Stimulation for Temper Outbursts in People With PWS
Foundation for Prader-Willi Research
NCT06144645
Tirzepatide in PWS, HO and GNSO
Grace Kim
NCT06901245
Impact of Bright Light Therapy on Prader-Willi Syndrome
Maimonides Medical Center
NCT05939453
Cerebellar TMS and Satiety in Prader-Willi Syndrome
Brigham and Women's Hospital
NCT05938543
Open-Label Extension Study of DCCR in Patients With Prader-Willi Syndrome
Soleno Therapeutics
NCT05701774
A Phase 2 Study to Evaluate the Safety and Efficacy of Pitolisant in Patients With Prader-Willi Syndrome, Followed by an Open Label Extension
Harmony Biosciences Management
NCT04257929
A Study of Setmelanotide in Patients With Prader-Willi Syndrome
Rhythm Pharmaceuticals
NCT06772597
Bioequivalence of Two Somatropin Products (Norditropin® Versus Genotropin®) in Healthy Adult Volunteers
Novo Nordisk A/S
NCT01401244
Oxytocin vs. Placebo for the Treatment Hyperphagia in Children and Adolescents With Prader-Willi Syndrome
Montefiore Medical Center
NCT02629991
A Study of Oral ARD-101 in Patients With Prader-Willi Syndrome
Aardvark Therapeutics
NCT05153434
CBDV vs Placebo in Children and Adults up to Age 30 With Prader-Willi Syndrome (PWS)
Montefiore Medical Center
NCT03848481
Clinical Study of Diazoxide Choline Controlled-Release Tablet (DCCR) in Patients With Prader-Willi Syndrome
Essentialis
NCT02034071
Growth Hormone Use in Adults With Prader-Willi Syndrome
Children's Mercy Hospital Kansas City
NCT00444964
Effects of Exenatide on Overweight Adolescents With Prader-Willi Syndrome
Children's Hospital Los Angeles
NCT01444898
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 5 |
| Phase 3 | 4 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Prader-Willi Syndrome records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Prader-Willi Syndrome trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Prader-Willi Syndrome page
17 registered trials, 7 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 7 Prader-Willi Syndrome trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Harmony Biosciences Management sponsors the most Prader-Willi Syndrome trials on record, review their full trial history before evaluating a specific study. See Harmony Biosciences Management's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Prader-Willi Syndrome condition card totals 17 registered trials; most-linked intervention DCCR; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.