Rhythm Pharmaceuticals

23 total trials 2 currently recruiting 18 completed

Rhythm Pharmaceuticals sponsors 23 registered US clinical trials on ClinicalTrials.gov, 2 of them currently recruiting, and 18 completed. 8 of these trials are in Phase 3-4 (later-stage) and 13 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Hypothalamic Obesity, with 3 trials.

Trial Pipeline

23 total, page 1 of 1

RECRUITING Phase 3

A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756)

NCT06760546

RECRUITING Phase 1

A Study of RM-718 in Healthy Subjects and Patients With MC4R Pathway Impairment

NCT06239116

ACTIVE NOT RECRUITING Phase 2

A Study of Setmelanotide in Patients With Prader-Willi Syndrome

NCT06772597

ACTIVE NOT RECRUITING Phase 3

A Trial of Setmelanotide in Acquired Hypothalamic Obesity

NCT05774756

ACTIVE NOT RECRUITING Phase 3

EMANATE: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway

NCT05093634

COMPLETED Phase 2

A Study to Assess Efficacy and Safety of LB54640 in Patients With Hypothalamic Obesity

NCT06046443

COMPLETED Phase 3

Setmelanotide in Pediatric Participants With Rare Genetic Diseases of Obesity

NCT04966741

COMPLETED Phase 3

Phase 3 Crossover Trial of Two Formulations of Setmelanotide in Participants With Specific Gene Defects in the MC4R Pathway

NCT05194124

COMPLETED Phase 2

DAYBREAK: A Study of Setmelanotide in Participants With Specific Gene Variants in the Melanocortin-4 Receptor (MC4R) Pathway

NCT04963231

COMPLETED Phase 4

Study of Setmelanotide Effects on QTc (Corrected QT) Interval in Healthy Participants

NCT05046132

COMPLETED Phase 2

Open-Label Study of Setmelanotide in Hypothalamic Obesity

NCT04725240

COMPLETED Phase 1

A Phase 1 Study to Evaluate the Pharmacokinetics of Setmelanotide in Subjects With Varying Degrees of Renal Impairment

NCT04348175

COMPLETED Phase 3

Setmelanotide (RM-493), Melanocortin-4 Receptor (MC4R) Agonist, in Bardet-Biedl Syndrome (BBS) and Alström Syndrome (AS) Participants With Moderate to Severe Obesity

NCT03746522

COMPLETED Phase 2

Long Term Extension Trial of Setmelanotide

NCT03651765

COMPLETED

The TEMPO (Tracing the Effect of the MC4 Pathway in Obesity) Registry

NCT03479437

COMPLETED Phase 2

Setmelanotide in a Single Patient With Partial Lipodystrophy

NCT03262610

COMPLETED Phase 3

Setmelanotide for the Treatment of Early-Onset Pro-Opiomelanocortin (POMC) Deficiency Obesity

NCT02896192

COMPLETED Phase 2

Setmelanotide Phase 2 Treatment Trial in Participants With Rare Genetic Disorders of Obesity

NCT03013543

COMPLETED

Genetic Testing and Phenotypic Characterization of Severely Obese Pediatric and Adult Volunteers

NCT02849977

COMPLETED Phase 2

Phase 2 Trial to Evaluate Safety and Efficacy of Setmelanotide (RM-493) in Obese Participants With Prader-Willi Syndrome

NCT02311673

COMPLETED Phase 1

Phase 1b/2a Study to Evaluate Safety and Efficacy of Setmelanotide in Obese Patients

NCT02041195

COMPLETED Phase 1

Effects of RM-493 on Energy Expenditure in Obese Individuals

NCT01867437

COMPLETED Phase 2

Phase 2 Study to Evaluate Safety and Efficacy of RM-493 in Obese Participants

NCT01749137

What the Pipeline for Rhythm Pharmaceuticals Shows

According to the ClinicalTrials.gov registry, Rhythm Pharmaceuticals is linked to 23 US clinical trials across every stage of research activity. Of those, 2 studies are currently recruiting, about 9% of the sponsor's indexed portfolio, and 18 are already marked complete, representing roughly 78% of the total.

The phase mix for Rhythm Pharmaceuticals reports 8 late-stage studies (Phase 3 and Phase 4 combined) and 13 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for Rhythm Pharmaceuticals is Hypothalamic Obesity with 3 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.