Rhythm Pharmaceuticals
Rhythm Pharmaceuticals sponsors 23 registered US clinical trials on ClinicalTrials.gov, 2 of them currently recruiting, and 18 completed. 8 of these trials are in Phase 3-4 (later-stage) and 13 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Hypothalamic Obesity, with 3 trials.
Trial Pipeline
23 total, page 1 of 1
A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756)
NCT06760546
A Study of RM-718 in Healthy Subjects and Patients With MC4R Pathway Impairment
NCT06239116
A Study of Setmelanotide in Patients With Prader-Willi Syndrome
NCT06772597
A Trial of Setmelanotide in Acquired Hypothalamic Obesity
NCT05774756
EMANATE: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway
NCT05093634
A Study to Assess Efficacy and Safety of LB54640 in Patients With Hypothalamic Obesity
NCT06046443
Setmelanotide in Pediatric Participants With Rare Genetic Diseases of Obesity
NCT04966741
Phase 3 Crossover Trial of Two Formulations of Setmelanotide in Participants With Specific Gene Defects in the MC4R Pathway
NCT05194124
DAYBREAK: A Study of Setmelanotide in Participants With Specific Gene Variants in the Melanocortin-4 Receptor (MC4R) Pathway
NCT04963231
Study of Setmelanotide Effects on QTc (Corrected QT) Interval in Healthy Participants
NCT05046132
Open-Label Study of Setmelanotide in Hypothalamic Obesity
NCT04725240
A Phase 1 Study to Evaluate the Pharmacokinetics of Setmelanotide in Subjects With Varying Degrees of Renal Impairment
NCT04348175
Setmelanotide (RM-493), Melanocortin-4 Receptor (MC4R) Agonist, in Bardet-Biedl Syndrome (BBS) and Alström Syndrome (AS) Participants With Moderate to Severe Obesity
NCT03746522
Long Term Extension Trial of Setmelanotide
NCT03651765
The TEMPO (Tracing the Effect of the MC4 Pathway in Obesity) Registry
NCT03479437
Setmelanotide in a Single Patient With Partial Lipodystrophy
NCT03262610
Setmelanotide for the Treatment of Early-Onset Pro-Opiomelanocortin (POMC) Deficiency Obesity
NCT02896192
Setmelanotide Phase 2 Treatment Trial in Participants With Rare Genetic Disorders of Obesity
NCT03013543
Genetic Testing and Phenotypic Characterization of Severely Obese Pediatric and Adult Volunteers
NCT02849977
Phase 2 Trial to Evaluate Safety and Efficacy of Setmelanotide (RM-493) in Obese Participants With Prader-Willi Syndrome
NCT02311673
Phase 1b/2a Study to Evaluate Safety and Efficacy of Setmelanotide in Obese Patients
NCT02041195
Effects of RM-493 on Energy Expenditure in Obese Individuals
NCT01867437
Phase 2 Study to Evaluate Safety and Efficacy of RM-493 in Obese Participants
NCT01749137
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 4 |
| Phase 2 | 9 |
| Phase 3 | 7 |
| Phase 4 | 1 |
Therapeutic Areas
What the Pipeline for Rhythm Pharmaceuticals Shows
According to the ClinicalTrials.gov registry, Rhythm Pharmaceuticals is linked to 23 US clinical trials across every stage of research activity. Of those, 2 studies are currently recruiting, about 9% of the sponsor's indexed portfolio, and 18 are already marked complete, representing roughly 78% of the total.
The phase mix for Rhythm Pharmaceuticals reports 8 late-stage studies (Phase 3 and Phase 4 combined) and 13 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for Rhythm Pharmaceuticals is Hypothalamic Obesity with 3 linked trials, and 9 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.