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ClinicalTrials.gov 9 recruiting now official registry

Paroxysmal Atrial Fibrillation clinical trials

9 of 25 indexed Paroxysmal Atrial Fibrillation trials are currently recruiting.

25 US clinical trials · 9 currently recruiting

Paroxysmal Atrial Fibrillation is the subject of 25 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is Boston Scientific Corporation, running 5 of these trials.

The research picture

Paroxysmal Atrial Fibrillation has 25 registered US clinical trials, 9 of them open to new participants right now, about 36% of the total.

9
recruiting participants now
36%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
5
top sponsor: Boston Scientific Corporation
Phase 21Phase 31Phase 43

Active & Recent Trials

25 total, page 1 of 1

RECRUITING 15,000 participants

Real-world Experience of Catheter Ablation for the Treatment of Paroxysmal and Persistent Atrial Fibrillation

Heart Rhythm Clinical and Research Solutions

NCT04088071

RECRUITING Phase 4 275 participants

Pragmatic Evaluation of a Pentaspline Pulsed Field Ablation System to Treat Atrial Fibrillation and Related Arrhythmias

Vivek Reddy

NCT06765356

RECRUITING NA 250 participants

ULTRA-HFIB-Redo: Ultrasound-based Renal Sympathetic Denervation vs Control in Redo Ablation Patients

Vivek Reddy

NCT05988411

RECRUITING 250 participants

The Long-term Safety and Effectiveness Evaluation of the QDOT MICRO System Use in Conjunction With VISITAG SURPOINT Module for the Treatment of Symptomatic Drug Refractory Paroxysmal Atrial Fibrillation.

Heart Rhythm Clinical and Research Solutions

NCT06324201

RECRUITING 200 participants

STOP AF First Post-Approval Study

Medtronic Cardiac Ablation Solutions

NCT05227053

RECRUITING NA 200 participants

POLARx Post Approval Study (POLARx PAS)

Boston Scientific Corporation

NCT06170606

RECRUITING NA 160 participants

Biomarker-Guided Optimization of Transcutaneous Vagal Stimulation for Atrial (BiG tVNS-AF)

University of Oklahoma

NCT05172765

RECRUITING 50 participants

Determinates of Atrial Tracking and Prevalence of Atrial Fibrillation in the Micra AV2 (DANCE AFIB)

Northwell Health

NCT07344961

RECRUITING 50 participants

EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation

Virginia Commonwealth University

NCT06212791

ACTIVE NOT RECRUITING NA 549 participants

Safety and Effectiveness of the Globe® Pulsed Field System for Treating Patients With Symptomatic Paroxysmal or Persistent Atrial Fibrillation

Kardium

NCT05462145

ACTIVE NOT RECRUITING 228 participants

ADVENT Post Approval Study

Boston Scientific Corporation

NCT06431815

ACTIVE NOT RECRUITING NA 128 participants

Treatment of PAF With the Synaptic System

Synaptic Medical Corporation

NCT05905835

ACTIVE NOT RECRUITING NA 50 participants

Meditation and Education That is Nurse Delivered for Symptom Management in Paroxysmal Atrial Fibrillation (PAF)

Stanford University

NCT03834844

ACTIVE NOT RECRUITING 49 participants

RHYTHMIA vs CARTO in Redo Ablation Procedures for Atrial Fibrillation

The Cleveland Clinic

NCT04835844

COMPLETED NA 706 participants

The FARAPULSE ADVENT PIVOTAL Trial PFA System vs SOC Ablation for Paroxysmal Atrial Fibrillation

Boston Scientific Corporation

NCT04612244

COMPLETED 364 participants

ADVENT Trial Long Term Outcomes Evaluating Atrial Fibrillation Progression Study

Boston Scientific Corporation

NCT06526546

COMPLETED NA 355 participants

TactiFlex Paroxysmal Atrial Fibrillation IDE Trial

Abbott Medical Devices

NCT04356040

COMPLETED Phase 4 333 participants

Evaluation of VISITAG SURPOINT™ Module With External Processing Unit (EPU)

Biosense Webster

NCT03624881

COMPLETED NA 321 participants

Clinical Evaluation of the StablePoint Catheter and Force Sensing System for Paroxysmal Atrial Fibrillation

Boston Scientific Corporation

NCT04580914

COMPLETED 320 participants

Cryoballoon PVI With PWI Versus PVI Alone In Patients With PAF

Sacramento EP Research

NCT05296824

COMPLETED Phase 3 245 participants

A Clinical Study of the Arctic Front Cryoablation Balloon for the Treatment of Paroxysmal Atrial Fibrillation

Medtronic Cardiac Rhythm and Heart Failure

NCT00523978

COMPLETED NA 178 participants

TactiCath® Contact Force Ablation Catheter Study for Atrial Fibrillation Post Approval Study

Abbott Medical Devices

NCT02310100

COMPLETED 143 participants

LSI (Lesion Index) Workflow Observational Study

Abbott Medical Devices

NCT03906461

COMPLETED Phase 4 112 participants

A Comparison of Antiarrhythmic Drug Therapy and Radio Frequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation

Biosense Webster

NCT00540787

COMPLETED Phase 2 100 participants

Clinical Study of the CardioFocus Endoscopic Ablation System - Adaptive Contact (EAS-AC) for the Treatment of Symptomatic Atrial Fibrillation

CardioFocus

NCT00971204

Phase Distribution

PhaseTrial count
Phase 2 1
Phase 3 1
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Paroxysmal Atrial Fibrillation Trial Landscape

25 indexed Paroxysmal Atrial Fibrillation studies · 9 recruiting (36%).

Phase mix: 4 late (III/IV) vs 1 early (I/II).

Top sponsor: Boston Scientific Corporation (5 trials), 9 others listed. 25 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Paroxysmal Atrial Fibrillation?

PlainTrial tracks 25 US clinical trials for Paroxysmal Atrial Fibrillation, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Paroxysmal Atrial Fibrillation?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.