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Paroxysmal Atrial Fibrillation
Open-data reference.
25 US clinical trials · 9 currently recruiting
Active & Recent Trials
Real-world Experience of Catheter Ablation for the Treatment of Paroxysmal and Persistent Atrial Fibrillation
Heart Rhythm Clinical and Research Solutions
NCT04088071
Pragmatic Evaluation of a Pentaspline Pulsed Field Ablation System to Treat Atrial Fibrillation and Related Arrhythmias
Vivek Reddy
NCT06765356
ULTRA-HFIB-Redo: Ultrasound-based Renal Sympathetic Denervation vs Control in Redo Ablation Patients
Vivek Reddy
NCT05988411
The Long-term Safety and Effectiveness Evaluation of the QDOT MICRO System Use in Conjunction With VISITAG SURPOINT Module for the Treatment of Symptomatic Drug Refractory Paroxysmal Atrial Fibrillation.
Heart Rhythm Clinical and Research Solutions
NCT06324201
STOP AF First Post-Approval Study
Medtronic Cardiac Ablation Solutions
NCT05227053
POLARx Post Approval Study (POLARx PAS)
Boston Scientific Corporation
NCT06170606
Biomarker-Guided Optimization of Transcutaneous Vagal Stimulation for Atrial (BiG tVNS-AF)
University of Oklahoma
NCT05172765
Determinates of Atrial Tracking and Prevalence of Atrial Fibrillation in the Micra AV2 (DANCE AFIB)
Northwell Health
NCT07344961
EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation
Virginia Commonwealth University
NCT06212791
Safety and Effectiveness of the Globe® Pulsed Field System for Treating Patients With Symptomatic Paroxysmal or Persistent Atrial Fibrillation
Kardium
NCT05462145
ADVENT Post Approval Study
Boston Scientific Corporation
NCT06431815
Treatment of PAF With the Synaptic System
Synaptic Medical Corporation
NCT05905835
Meditation and Education That is Nurse Delivered for Symptom Management in Paroxysmal Atrial Fibrillation (PAF)
Stanford University
NCT03834844
RHYTHMIA vs CARTO in Redo Ablation Procedures for Atrial Fibrillation
The Cleveland Clinic
NCT04835844
The FARAPULSE ADVENT PIVOTAL Trial PFA System vs SOC Ablation for Paroxysmal Atrial Fibrillation
Boston Scientific Corporation
NCT04612244
ADVENT Trial Long Term Outcomes Evaluating Atrial Fibrillation Progression Study
Boston Scientific Corporation
NCT06526546
TactiFlex Paroxysmal Atrial Fibrillation IDE Trial
Abbott Medical Devices
NCT04356040
Evaluation of VISITAG SURPOINT™ Module With External Processing Unit (EPU)
Biosense Webster
NCT03624881
Clinical Evaluation of the StablePoint Catheter and Force Sensing System for Paroxysmal Atrial Fibrillation
Boston Scientific Corporation
NCT04580914
Cryoballoon PVI With PWI Versus PVI Alone In Patients With PAF
Sacramento EP Research
NCT05296824
A Clinical Study of the Arctic Front Cryoablation Balloon for the Treatment of Paroxysmal Atrial Fibrillation
Medtronic Cardiac Rhythm and Heart Failure
NCT00523978
TactiCath® Contact Force Ablation Catheter Study for Atrial Fibrillation Post Approval Study
Abbott Medical Devices
NCT02310100
LSI (Lesion Index) Workflow Observational Study
Abbott Medical Devices
NCT03906461
A Comparison of Antiarrhythmic Drug Therapy and Radio Frequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation
Biosense Webster
NCT00540787
Clinical Study of the CardioFocus Endoscopic Ablation System - Adaptive Contact (EAS-AC) for the Treatment of Symptomatic Atrial Fibrillation
CardioFocus
NCT00971204
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 1 |
| Phase 3 | 1 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Paroxysmal Atrial Fibrillation Trial Landscape
ClinicalTrials.gov lists 25 US studies indexed under Paroxysmal Atrial Fibrillation, and 9 of those are currently open to recruitment — roughly 36% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Paroxysmal Atrial Fibrillation shows 4 late-stage studies (Phase 3 and Phase 4 combined) alongside 1 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Paroxysmal Atrial Fibrillation is led by Boston Scientific Corporation with 5 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 25 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Paroxysmal Atrial Fibrillation?
PlainTrial tracks 25 US clinical trials for Paroxysmal Atrial Fibrillation, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Paroxysmal Atrial Fibrillation?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.