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Osteoarthritis of the Knee: early-phase trial registry
3 of 17 indexed Osteoarthritis of the Knee trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #1,004 of 28,707 conditions by registered trial count.
17 US clinical trials · 3 currently recruiting · #1,004 of 28,707 conditions by registered trial count
Osteoarthritis of the Knee: 17 US clinical trials tracked, 3 recruiting.
Osteoarthritis of the Knee is the subject of 17 registered US clinical trials on ClinicalTrials.gov, 3 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is Pacira Pharmaceuticals, running 4 of these trials.
Enrollment posture brief
Registry condition osteoarthritis-of-the-knee
OPEN 3 | RECR 18% | LATE 4 | EARLY 7 | RANK #1004 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Advanced Malignant Neoplasm (18% recruiting · 17 trials)
Osteoarthritis of the Knee lists 3 open slots (18% of 17 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Osteoarthritis of the Knee on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Osteoarthritis of the Knee is recruiting below its size-band peers.
3 of 17 indexed trials (17.6%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Osteoarthritis of the Knee research.
Pacira Pharmaceuticals accounts for 4 of 17 trials (23.5%). 13 distinct sponsors appear on at least one study for this condition label.
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Typical Osteoarthritis of the Knee enrolment sits around 177 participants.
Median target enrolment is 177 among the 17 trials that report a genuine target (sentinel values excluded). 5 of those (29.4%) plan for fewer than 100 participants.
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Osteoarthritis of the Knee research is mostly interventional.
17 interventional and 0 observational studies make up this index (100% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
17 total, page 1 of 1
Cannabinoid Interactions With Central and Peripheral Pain Mechanisms in Osteoarthritis of the Knee
Steven E Harte, PhD
NCT04992624
Bone Marrow Aspirate Concentrate (BMAC) vs Corticosteroid Injection
Rush University Medical Center
NCT05985785
Home-Based Leg Dexterity Trainer for Management of Knee Osteoarthritis
Steadman Philippon Research Institute
NCT07397806
A Pragmatic Trial to Determine the Benefit of Behaviorally Enhanced Exercise Incentives and Corticosteroid Injections in Osteoarthritis of the Knee Marching On for Veterans With Osteoarthritis of the Knee
VA Office of Research and Development
NCT05035810
Extended and Controlled Release Liposomal Formulated Dexamethasone for Chronic Knee OA Pain
Taiwan Liposome Company
NCT04123561
Study of FX006 for the Treatment of Pain in Patients With Osteoarthritis of the Knee
Pacira Pharmaceuticals
NCT02357459
A Study to Evaluate the Safety and Efficacy of Topically Applied TV-45070 (Ointment) in Participants With Primary Osteoarthritis (OA) Affecting a Single Knee
Teva Branded Pharmaceutical Products R&D
NCT02068599
Study of FX006 vs Normal Saline in Patients With Osteoarthritis of the Knee
Pacira Pharmaceuticals
NCT02116972
A 4-week Study to Evaluate the Efficacy and Safety of HP-5000 in Subjects With Knee Osteoarthritis
Noven Pharmaceuticals
NCT03277066
Study to Assess the Safety of Repeat Administration of FX006 Administered to Patients With Osteoarthritis of the Knee
Pacira Pharmaceuticals
NCT03046446
Cooled Radiofrequency vs. Hyaluronic Acid to Manage Knee Pain
Avanos Medical
NCT03381248
Coolief Cooled Radiofrequency vs. Conventional Radiofrequency to Manage OA Knee Pain
Avanos Medical
NCT04145011
Nerve Ablation by Cooled Radiofrequency Compared to Corticosteroid Injection for Management of Knee Pain
Halyard Health
NCT02343003
Sleep, Pain and Inflammatory Processes in Older Adults With Osteoarthritis
University of Rochester
NCT01683799
Study to Assess the Effects of FX006 on Blood Glucose in Patients With OA of the Knee and Type 2 Diabetes
Pacira Pharmaceuticals
NCT02762370
Effects of Aquamin F on NSAID Dose Reduction in Osteoarthritis of the Knee
Marigot
NCT00755482
Hydroxychloroquine/Atorvastatin in the Treatment of Osteoarthritis (OA) of the Knee
Stanford University
NCT01645176
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 6 |
| Phase 3 | 4 |
Top Sponsors
Named interventions
Most-linked intervention names on Osteoarthritis of the Knee records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Osteoarthritis of the Knee trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Osteoarthritis of the Knee page
17 registered trials, 3 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 3 Osteoarthritis of the Knee trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Pacira Pharmaceuticals sponsors the most Osteoarthritis of the Knee trials on record, review their full trial history before evaluating a specific study. See Pacira Pharmaceuticals's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Osteoarthritis of the Knee condition card totals 17 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.