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A Pragmatic Trial to Determine the Benefit of Behaviorally Enhanced Exercise Incentives and Corticosteroid Injections in Osteoarthritis of the Knee Marching On for Veterans With Osteoarthritis of the Knee
NCT05035810 · View on ClinicalTrials.gov ↗
Study Summary
Knee osteoarthritis (KOA) is one of the most common and disabling conditions among Veterans. Management of KOA is challenging as there are few effective treatments other than joint replacement. Importantly, low levels of physical activity in patients with knee problems might worsen pain and disability. This study aims to determine the feasibility of using methods to change behavior that use social incentives and promote physical activity through playing games and interacting with a web-based platform. The study will also evaluate an important and widely used treatment, namely corticosteroid injections. Participants will be randomized into one of 4 arms and will receive a different combination of social incentives and injections. The study will evaluate which approach is most effective at promoting physical activity and reducing pain and disability.
Conditions Studied
Interventions
- BEHAVIORAL Social Incentives and Gamification to Promote Exercise
- DRUG Corticosteroid Injection given in A-B order
- BEHAVIORAL No Social Incentive applied
- DRUG Procedure: Corticosteroid Injection given in B-A order
Study Locations (4)
District of Columbia
- Washington DC VA Medical Center, Washington, DC — Washington D.C.
Nebraska
- Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE — Omaha
Pennsylvania
- Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA — Philadelphia
Washington
- VA Puget Sound Health Care System Seattle Division, Seattle, WA — Seattle
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 221 participants |
| Start Date | 2022-03-14 |
| Est. Completion | 2025-12-31 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05035810
The ClinicalTrials.gov registry entry for NCT05035810 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 221 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is VA Office of Research and Development, which has 1,863 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Osteoarthritis of the Knee appearing as the primary indexed condition, and to 4 interventions — of which Social Incentives and Gamification to Promote Exercise is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05035810 reports 4 study locations spanning 4 distinct geographic areas — top geographies include District of Columbia, Nebraska, Pennsylvania. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05035810 about?
NCT05035810 is a clinical study titled "A Pragmatic Trial to Determine the Benefit of Behaviorally Enhanced Exercise Incentives and Corticosteroid Injections in Osteoarthritis of the Knee Marching On for Veterans With Osteoarthritis of the Knee". Knee osteoarthritis (KOA) is one of the most common and disabling conditions among Veterans. Management of KOA is challenging as there are few effective treatments other than joint replacement. Importantly, low levels of physical activity in patients with knee problems might worsen pain and disabili...
What is the current status of trial NCT05035810?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 221 participants. The study started on 2022-03-14. Estimated completion is 2025-12-31.
What conditions does trial NCT05035810 study?
This clinical trial studies the following conditions: Osteoarthritis of the Knee. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05035810?
The interventions under investigation include: Social Incentives and Gamification to Promote Exercise (BEHAVIORAL), Corticosteroid Injection given in A-B order (DRUG), No Social Incentive applied (BEHAVIORAL), Procedure: Corticosteroid Injection given in B-A order (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05035810?
This trial is sponsored by VA Office of Research and Development, which has 1,863 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05035810 being conducted?
This trial has 4 study locations across District of Columbia, Nebraska, Pennsylvania, Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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