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NCT05035810 · ClinicalTrials.gov registry record · Phase 3
A Pragmatic Trial to Determine the Benefit of Behaviorally Enhanced Exercise Incentives and Corticosteroid Injections in Osteoarthritis of the Knee Marching On for Veterans With Osteoarthritis of the Knee
A Phase 3 study of Osteoarthritis of the Knee, sponsored by VA Office of Research and Development.
- Active
- Registry status
- Phase 3
- Development phase
- 221
- Enrollment target
- 4
- Study locations
NCT05035810: Active Phase 3 study of Osteoarthritis of the Knee, sponsored by VA Office of Research and Development.
NCT05035810 is a Phase 3 study of Osteoarthritis of the Knee that is active but no longer recruiting, run by VA Office of Research and Development. The registered enrollment target is 221 participants, above the 199-participant average among 16 other Osteoarthritis of the Knee trials with a reported enrollment target (11% higher). The trial reports 4 study locations across 4 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05035810, a Phase 3 study of Osteoarthritis of the Knee, is active but no longer recruiting, sponsored by VA Office of Research and Development.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 3
- Development phase
- 221 participants
- Enrollment target
- 4
- Study locations
Study Summary
Knee osteoarthritis (KOA) is one of the most common and disabling conditions among Veterans. Management of KOA is challenging as there are few effective treatments other than joint replacement. Importantly, low levels of physical activity in patients with knee problems might worsen pain and disability. This study aims to determine the feasibility of using methods to change behavior that use social incentives and promote physical activity through playing games and interacting with a web-based platform. The study will also evaluate an important and widely used treatment, namely corticosteroid injections. Participants will be randomized into one of 4 arms and will receive a different combination of social incentives and injections. The study will evaluate which approach is most effective at promoting physical activity and reducing pain and disability.
Primary Outcome
Steps measured by a wearable activity monitor
Conditions Studied
Interventions
- BEHAVIORAL Social Incentives and Gamification to Promote Exercise
- DRUG Corticosteroid Injection given in A-B order
- BEHAVIORAL No Social Incentive applied
- DRUG Procedure: Corticosteroid Injection given in B-A order
Study Locations (4)
District of Columbia
- Washington DC VA Medical Center, Washington, DC - Washington D.C.
Nebraska
- Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE - Omaha
Pennsylvania
- Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA - Philadelphia
Washington
- VA Puget Sound Health Care System Seattle Division, Seattle, WA - Seattle
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 221 participants |
| Start Date | 2022-03-14 |
| Est. Completion | 2025-12-31 |
| Phase | Phase 3 |
What the registry record for NCT05035810 still lists
NCT05035810 is an interventional study that assigns participants to a tested intervention. The registered 221 participants enrollment target is mid-sized for trials with a published cap, above the 199-participant average among 16 other Osteoarthritis of the Knee trials with a reported enrollment target (11% higher).
The record links to 1 condition, with Osteoarthritis of the Knee appearing as the primary indexed condition, and to 4 interventions - of which Social Incentives and Gamification to Promote Exercise is the first listed.
NCT05035810 reports a single indexed study location in District of Columbia, Nebraska, Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT05035810 about?
NCT05035810 is a clinical study titled "A Pragmatic Trial to Determine the Benefit of Behaviorally Enhanced Exercise Incentives and Corticosteroid Injections in Osteoarthritis of the Knee Marching On for Veterans With Osteoarthritis of the Knee". Knee osteoarthritis (KOA) is one of the most common and disabling conditions among Veterans. Management of KOA is challenging as there are few effective treatments other than joint replacement. Importantly, low levels of physical activity in patients with knee problems might worsen pain and disabili...
What is the current status of trial NCT05035810?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 221 participants. The study started on 2022-03-14. Estimated completion is 2025-12-31.
What conditions does trial NCT05035810 study?
This clinical trial studies the following conditions: Osteoarthritis of the Knee.
What interventions are being tested in trial NCT05035810?
The interventions under investigation include: Social Incentives and Gamification to Promote Exercise (BEHAVIORAL), Corticosteroid Injection given in A-B order (DRUG), No Social Incentive applied (BEHAVIORAL), Procedure: Corticosteroid Injection given in B-A order (DRUG).
Who is sponsoring clinical trial NCT05035810?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05035810 being conducted?
This trial has 4 study locations across District of Columbia, Nebraska, Pennsylvania, Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Osteoarthritis of the Knee
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05035810's enrollment target sits among peer trials
221 6th of 16 higher than 11 of 16 other Osteoarthritis of the Knee trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Osteoarthritis of the Knee trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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