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ClinicalTrials.gov 8 recruiting now early-phase tilt

Obese: early-phase trial registry

8 of 28 indexed Obese trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #577 of 28,707 conditions by registered trial count.

28 US clinical trials · 8 currently recruiting · #577 of 28,707 conditions by registered trial count

Obese: 28 US clinical trials tracked, 8 recruiting.

Obese is the subject of 28 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is Arkansas Children's Hospital Research Institute, running 2 of these trials.

Enrollment posture brief

Registry condition obese

OPEN 8 | RECR 29% | LATE 2 | EARLY 7 | RANK #577 | SPON 2

Nearest open-share peer: Acne Scars (29% recruiting · 7 trials)

Obese (this)29%Anatomic Stage IB Breast Can25%Carcinoma, Hepatocellular25%Autistic Disorder17.9%Cocaine-Related Disorders0%
Open-enrollment share among volume-matched conditions near Obese

Obese lists 8 open slots (29% of 28 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Obese on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Obese is recruiting below its size-band peers.

    8 of 28 indexed trials (28.6%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. Sponsorship of Obese trials is spread across many organizations.

    Arkansas Children's Hospital Research Institute accounts for 2 of 28 trials (7.1%). 23 distinct sponsors appear on at least one study for this condition label.

  3. Typical Obese enrolment sits around 100 participants.

    Median target enrolment is 100 among the 28 trials that report a genuine target (sentinel values excluded). 12 of those (42.9%) plan for fewer than 100 participants.

  4. Obese research is mostly interventional.

    25 interventional and 3 observational studies make up this index (89.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 13Phase 24Phase 32

Open and recent trials

28 total, page 1 of 1

RECRUITING Phase 2 1,785 participants

Taxi ROADmAP (Realizing Optimization Around Diet And Physical Activity)

Memorial Sloan Kettering Cancer Center

NCT05770570

RECRUITING Phase 2 250 participants

Study to Evaluate HM15275 in Obese or Overweight Subjects Without Diabetes Mellitus

Hanmi Pharmaceutical Company Limited

NCT07205900

RECRUITING 120 participants

Exercise Response in Humans With Obesity

Mayo Clinic

NCT05857150

RECRUITING NA 100 participants

Trans-nasal Endoscopy for Bariatric Patients

Christopher C. Thompson, MD, MSc

NCT06200961

RECRUITING Phase 3 80 participants

Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome

University of Colorado, Denver

NCT05819853

RECRUITING Phase 2 50 participants

Aleniglipron Phase 2 in Type 2 Diabetes Mellitus

Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics

NCT07400588

RECRUITING Phase 1 40 participants

A Single Ascending Dose Study of HM17321 in Healthy Adult Participants

Hanmi Pharmaceutical Company Limited

NCT07219589

RECRUITING Early Phase 1 30 participants

Study of Liraglutide (A Weight Loss Drug) in High Risk Obese Participants With Cognitive and Memory Issues

University of Chicago

NCT06171152

ACTIVE NOT RECRUITING NA 284 participants

The Expecting Study

Arkansas Children's Hospital Research Institute

NCT02125149

ACTIVE NOT RECRUITING NA 151 participants

Brain Fuel - Morning Nutrition and Cognitive Function

Arkansas Children's Hospital Research Institute

NCT03386396

ACTIVE NOT RECRUITING NA 100 participants

Project 1: Diet and Exercise Modulate the Sperm Epigenome in Men

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

NCT04175678

ACTIVE NOT RECRUITING 90 participants

Influence of Changes in Food Group Variety on Food Cravings, Energy Intake, and Weight Loss After Bariatric Surgery

The University of Tennessee, Knoxville

NCT01399177

ACTIVE NOT RECRUITING NA 44 participants

Olive Oil Polyphenols and Cardiovascular Health Biomarkers

University of California, Davis

NCT04149288

COMPLETED NA 668 participants

Financial Incentives for Weight Reduction Study

University of California, Los Angeles

NCT03157713

COMPLETED NA 301 participants

Self-Retaining Retractor in Obese Patients Undergoing Cesarean Section

St. Louis University

NCT01826604

COMPLETED NA 245 participants

Metabolism, Exercise and Nutrition at UCSD (MENU Study)

University of California, San Diego

NCT01424007

COMPLETED NA 241 participants

Families Improving Together (FIT) for Weight Loss

University of South Carolina

NCT01796067

COMPLETED NA 227 participants

UCSD Take Charge Study

University of California, San Diego

NCT01345500

COMPLETED NA 212 participants

mFit: The Mobile Fitness Project

University of California, Los Angeles

NCT01650337

COMPLETED 154 participants

Post-delivery Maternal-offspring Obesity and Metabolic Risk After a Prepregnancy Weight-loss Intervention

Kaiser Permanente

NCT06067126

COMPLETED Phase 2 141 participants

PDE5 Inhibition for Obesity-Related Cardiometabolic Dysfunction

Vanderbilt University Medical Center

NCT02819440

COMPLETED NA 100 participants

Prone Versus Left-sided Colonoscopy in Obese Patients

Dallas VA Medical Center

NCT01616602

COMPLETED NA 97 participants

Second Generation LMA Versus Endotracheal Tube in Obese Patients

University of Texas Southwestern Medical Center

NCT03748342

COMPLETED Phase 3 77 participants

Evaluating the Effects Two Diets Combined With Exercise in Persons With Abdominal Obesity (The SHAPE5 Study)

Johns Hopkins University

NCT00990457

COMPLETED NA 67 participants

Fit and Trim for Diabetes Prevention

University of California, San Francisco

NCT02278939

COMPLETED NA 29 participants

Exercise and Weight Control

USDA Grand Forks Human Nutrition Research Center

NCT02152501

COMPLETED NA 16 participants

Mitochondrial Dysfunction in Diabetes

Mayo Clinic

NCT01724502

COMPLETED Phase 1 12 participants

In Vivo Leptin Signaling in Humans After Acute Leptin Administration

Beth Israel Deaconess Medical Center

NCT01275053

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 4
Phase 3 2

Named interventions

Most-linked intervention names on Obese records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Placebo Drug
2 trials
Individualized Counseling Other
1 trials
Lower carbohydrate, Higher fat diet Other
1 trials
Higher Carbohydrate, Lower Fat Diet Other
1 trials
Online Control Behavioral
1 trials
Online Intervention Behavioral
1 trials
Basic Health Education Behavioral
1 trials
Motivational and Family Weight Loss Behavioral
1 trials

US sites by state

Facility locations filed on Obese trials. A trial with sites in several states counts in each.

California 9 trials
Texas 4 trials
Tennessee 4 trials
South Carolina 3 trials
Ohio 2 trials
New York 2 trials
Missouri 2 trials
Minnesota 2 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Obese page

28 registered trials, 8 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Obese condition card totals 28 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.