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ClinicalTrials.gov 48 recruiting now official registry

NSCLC clinical trials

48 of 72 indexed NSCLC trials are currently recruiting.

72 US clinical trials · 48 currently recruiting

NSCLC is the subject of 72 registered US clinical trials on ClinicalTrials.gov, 48 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 55 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 6 of these trials.

The research picture

NSCLC has 72 registered US clinical trials, 48 of them open to new participants right now, about 67% of the total.

48
recruiting participants now
67%
of trials open to enrollment
8
in Phase 3–4 (later-stage)
6
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 141Phase 214Phase 37Phase 41

Active & Recent Trials

72 total, page 2 of 2

ACTIVE NOT RECRUITING Phase 1 440 participants

A Study of CLN-619 Alone and in Combination With Pembrolizumab in Advanced Solid Tumors

Cullinan Therapeutics

NCT05117476

ACTIVE NOT RECRUITING Phase 1 320 participants

A Phase 1/2 Study of BA3071 in Patients With Solid Tumors

BioAtla

NCT05180799

ACTIVE NOT RECRUITING 250 participants

Epidemiology of Young Lung Cancer - Survey

Addario Lung Cancer Medical Institute

NCT04640259

ACTIVE NOT RECRUITING Phase 1 200 participants

Phase 1/2 Study of Silevertinib (BDTX-1535) in Patients With Glioblastoma or Non-Small Cell Lung Cancer With EGFR Mutations

Black Diamond Therapeutics

NCT05256290

ACTIVE NOT RECRUITING Phase 1 180 participants

Study to Evaluate D-1553 in Subjects With Solid Tumors

InventisBio Co.

NCT04585035

ACTIVE NOT RECRUITING Phase 2 178 participants

Atezolizumab Immunotherapy With or Without Tiragolumab for Patients With Unresectable Stage III NSCLC

Alliance Foundation Trials

NCT05798663

ACTIVE NOT RECRUITING Phase 1 174 participants

Study of Oral MRT-2359 in Selected Cancer Patients

Monte Rosa Therapeutics

NCT05546268

ACTIVE NOT RECRUITING Phase 1 160 participants

A Study to Evaluate the Safety and Efficacy of A2B530, a Logic-gated CAR T, in Participants With Solid Tumors That Express CEA and Have Lost HLA-A*02 Expression

A2 Biotherapeutics

NCT05736731

ACTIVE NOT RECRUITING Phase 2 107 participants

Randomized Study of Stereotactic Body Radiation Therapy (SBRT) in Patients With Oligoprogressive Metastatic Cancers of the Breast and Lung

Memorial Sloan Kettering Cancer Center

NCT03808662

ACTIVE NOT RECRUITING Phase 2 100 participants

Adjuvant Treatment With Cisplatin-based Chemotherapy Plus Concomitant Atezolizumab in Patients With Stage I (Tumors ≥ 4cm), IIA, IIB, and Select Stage III [Any T1-3 N1-2 and T4N0-2] Resected Non-small Cell Lung Cancer (NSCLC) and the Clearance of Circulating Tumor DNA (ctDNA)

Nasser Hanna

NCT04367311

ACTIVE NOT RECRUITING Phase 4 76 participants

Lorlatinib Continuation Study

Pfizer

NCT05144997

ACTIVE NOT RECRUITING Phase 3 68 participants

Continued Access Study for Participants Deriving Benefit in Pfizer-Sponsored Avelumab Parent Studies That Are Closing

Pfizer

NCT05059522

ACTIVE NOT RECRUITING Phase 2 61 participants

Determining Whether Durvalumab in Combination With Radiation Therapy Can Prevent the Progression of Non-Small Cell Lung Cancer

Memorial Sloan Kettering Cancer Center

NCT03999710

ACTIVE NOT RECRUITING Phase 2 43 participants

A Phase 2 Study Adding Ascorbate to Chemotherapy and Radiation Therapy for NSCLC

Joseph J. Cullen, MD, FACS

NCT02905591

ACTIVE NOT RECRUITING Phase 2 13 participants

Treating Early-stage Non-Small Cell Lung Cancer With Durvalumab and Radiation Therapy

Memorial Sloan Kettering Cancer Center

NCT04716946

COMPLETED Phase 3 161 participants

Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors

Dan Zandberg

NCT04157985

COMPLETED Phase 1 73 participants

A Bioequivalence Study Between the Proposed and Current Talazoparib Capsule Formulation and Food Effect Study for the Proposed Talazoparib Capsule Formulation in Participants With Advanced Solid Tumors

Pfizer

NCT04672460

COMPLETED Phase 1 56 participants

A Study of PEGylated Recombinant Human Hyaluronidase (PEGPH20) With Pembrolizumab in Participants With Selected Hyaluronan High Solid Tumors

Halozyme Therapeutics

NCT02563548

COMPLETED Phase 1 43 participants

Study of the CD40 Agonistic Monoclonal Antibody APX005M

Apexigen America

NCT02482168

COMPLETED Phase 1 29 participants

JAB-21822 Activity in Adult Patients With Advanced Solid Tumors Harboring KRAS G12C Mutation

Jacobio Pharmaceuticals Co.

NCT05002270

COMPLETED Phase 1 12 participants

IRX-2 Regimen Combined With Nivolumab in Recurrent/Metastatic Solid Tumors

H. Lee Moffitt Cancer Center and Research Institute

NCT03758781

COMPLETED Phase 1 6 participants

Osimertinib With Stereotactic Radiosurgery (SRS) in Brain Metastases From EGFR Positive NSCLC

Case Comprehensive Cancer Center

NCT03535363

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Phase Distribution

PhaseTrial count
Phase 1 41
Phase 2 14
Phase 3 7
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the NSCLC Trial Landscape

72 indexed NSCLC studies · 48 recruiting (67%).

Phase mix: 8 late (III/IV) vs 55 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (6 trials), 9 others listed. 22 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for NSCLC?

PlainTrial tracks 72 US clinical trials for NSCLC, of which 48 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for NSCLC?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.