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Atezolizumab Immunotherapy With or Without Tiragolumab for Patients With Unresectable Stage III NSCLC
NCT05798663 · View on ClinicalTrials.gov ↗
Study Summary
This is a phase II trial of neoadjuvant and adjuvant atezolizumab with or without tiragolumab in conjunction with chemoradiotherapy for unresectable stage III NSCLC.
Conditions Studied
Interventions
- DRUG Atezolizumab
- DRUG Tiragolumab
Study Locations (15)
California
- University of California San Diego Moores Cancer Center — La Jolla
- Kaiser Permanente Oakland Medical Center — Oakland
- Kaiser Permanente Roseville Medical Center — Roseville
- Kaiser Permanente San Francisco Medical Center — San Francisco
- Kaiser Permanente Santa Clara Medical Center — Santa Clara
- Kaiser Permanente Vallejo Medical Center — Vallejo
Missouri
- Washington University Siteman Cancer Center — St Louis
- Missouri Baptist Medical Center — St Louis
New York
- Hematology Oncology Associates of Central New York, P.C. — East Syracuse
- SUNY Upstate Medical University — Syracuse
Illinois
- Rush University Medical Center — Chicago
Nebraska
- University of Nebraska Medical Center — Omaha
New Hampshire
- New Hampshire Oncology - Hematology, PA — Manchester
Ohio
- Ohio State University — Columbus
Wisconsin
- University of Wisconsin — Madison
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 178 participants |
| Start Date | 2023-12-07 |
| Est. Completion | 2026-11 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05798663
The ClinicalTrials.gov registry entry for NCT05798663 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 178 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Alliance Foundation Trials, which has 71 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with NSCLC appearing as the primary indexed condition, and to 2 interventions — of which Atezolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05798663 reports 15 study locations spanning 8 distinct geographic areas — top geographies include California, Missouri, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05798663 about?
NCT05798663 is a clinical study titled "Atezolizumab Immunotherapy With or Without Tiragolumab for Patients With Unresectable Stage III NSCLC". This is a phase II trial of neoadjuvant and adjuvant atezolizumab with or without tiragolumab in conjunction with chemoradiotherapy for unresectable stage III NSCLC.
What is the current status of trial NCT05798663?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 178 participants. The study started on 2023-12-07. Estimated completion is 2026-11.
What conditions does trial NCT05798663 study?
This clinical trial studies the following conditions: NSCLC. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05798663?
The interventions under investigation include: Atezolizumab (DRUG), Tiragolumab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05798663?
This trial is sponsored by Alliance Foundation Trials, which has 71 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05798663 being conducted?
This trial has 15 study locations across California, Illinois, Missouri, Nebraska, New Hampshire. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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