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Neovascular Age-related Macular Degeneration (nAMD) clinical trials
5 of 10 indexed Neovascular Age-related Macular Degeneration (nAMD) trials are currently recruiting.
10 US clinical trials · 5 currently recruiting
Neovascular Age-related Macular Degeneration (nAMD) is the subject of 10 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Adverum Biotechnologies, running 2 of these trials.
The research picture
Neovascular Age-related Macular Degeneration (nAMD) has 10 registered US clinical trials, 5 of them open to new participants right now, about 50% of the total.
- 5
- recruiting participants now
- 50%
- of trials open to enrollment
- 6
- in Phase 3–4 (later-stage)
- 2
- top sponsor: Adverum Biotechnologies
Active & Recent Trials
10 total, page 1 of 1
Single Intravitreal (IVT) Injection of 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration
4D Molecular Therapeutics
NCT07064759
Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-related Macular Degeneration (AQUARIUS)
Adverum Biotechnologies
NCT07482176
Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-Related Macular Degeneration
Adverum Biotechnologies
NCT06856577
Study of AR-14034 in Participants With Neovascular Age-Related Macular Degeneration (nAMD)
Alcon Research
NCT05769153
Safety and Tolerability of OCU-10-C-110 for Injection in Subjects With Neovascular Age-related Macular Degeneration
Ocugenix Corporation
NCT05904691
A Study to Determine the Efficacy, Safety, and Durability of Faricimab in Participants With Neovascular Age-Related Macular Degeneration
Hoffmann-La Roche
NCT06795048
Study to Assess the Efficacy & Safety of KHK4951 in Patients With Neovascular Age-Related Macular Degeneration
Kyowa Kirin Co.
NCT06116890
RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Neovascular Age-Related Macular Degeneration (nAMD)
AbbVie
NCT04514653
Study of the Safety of Use of Intravitreal SOK583A1 Provided in a Vial Kit
Sandoz
NCT05282004
Study of the Safety of Use of Intravitreal SOK583A1 Provided in a Prefilled Syringe
Sandoz
NCT05161806
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 2 |
| Phase 3 | 5 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Neovascular Age-related Macular Degeneration (nAMD) Trial Landscape
10 indexed Neovascular Age-related Macular Degeneration (nAMD) studies · 5 recruiting (50%).
Phase mix: 6 late (III/IV) vs 4 early (I/II).
Top sponsor: Adverum Biotechnologies (2 trials), 7 others listed. 10 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Neovascular Age-related Macular Degeneration (nAMD)?
PlainTrial tracks 10 US clinical trials for Neovascular Age-related Macular Degeneration (nAMD), of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Neovascular Age-related Macular Degeneration (nAMD)?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.