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Study of AR-14034 in Participants With Neovascular Age-Related Macular Degeneration (nAMD)
NCT05769153 · View on ClinicalTrials.gov ↗
Study Summary
The primary purpose of this study is to evaluate the safety and durability of single- and repeat administration of AR-14034 Sustained Release (SR) in subjects with neovascular age-related macular degeneration (nAMD).
Conditions Studied
Interventions
- DRUG AR-14034 SR implant lower dose
- DRUG AR-14034 SR implant higher dose
- DRUG AR-14034 SR implant
- DRUG Aflibercept Injection
- DRUG Sham procedure
Study Locations (20)
Florida
- Florida Retina Institute — Jacksonville
- Mid Florida Eye Center — Mt. Dora
- Florida Retina Institute — Orlando
- Retina Specialty Institute — Pensacola
- Eye Associates of Pinellas — Pinellas Park
- Center for Retina and Macular Disease — Winter Haven
California
- The Retina Partners — Encino
- Retina Associates of Orange County — Laguna Hills
- Northern California Retina Vitreous Associates Medical Group — Mountain View
- Eye Research Foundation — Newport Beach
- Azul Vision Pasadena — Pasadena
Arizona
- Associated Retina Consultants - Gilbert — Gilbert
- Associated Retina Consultants - Phoenix — Phoenix
- Retina Associates of SW PC — Tucson
Georgia
- Southeast Retina Center — Augusta
- Thomas Eye Group Main Office — Sandy Springs
Alabama
- Trinity Research Group — Dothan
Colorado
- Retina Consultants of Southern Colorado — Colorado Springs
Connecticut
- Retina Group of New England | Waterford — Waterford
Illinois
- University Retina and Macula Associates, PC — Oak Forest
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 140 participants |
| Start Date | 2023-12-06 |
| Est. Completion | 2027-10 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05769153
The ClinicalTrials.gov registry entry for NCT05769153 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 140 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Alcon Research, which has 111 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Neovascular Age-related Macular Degeneration (nAMD) appearing as the primary indexed condition, and to 5 interventions — of which AR-14034 SR implant lower dose is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05769153 reports 20 study locations spanning 8 distinct geographic areas — top geographies include Florida, California, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05769153 about?
NCT05769153 is a clinical study titled "Study of AR-14034 in Participants With Neovascular Age-Related Macular Degeneration (nAMD)". The primary purpose of this study is to evaluate the safety and durability of single- and repeat administration of AR-14034 Sustained Release (SR) in subjects with neovascular age-related macular degeneration (nAMD).
What is the current status of trial NCT05769153?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 140 participants. The study started on 2023-12-06. Estimated completion is 2027-10.
What conditions does trial NCT05769153 study?
This clinical trial studies the following conditions: Neovascular Age-related Macular Degeneration (nAMD). These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05769153?
The interventions under investigation include: AR-14034 SR implant lower dose (DRUG), AR-14034 SR implant higher dose (DRUG), AR-14034 SR implant (DRUG), Aflibercept Injection (DRUG), Sham procedure (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05769153?
This trial is sponsored by Alcon Research, which has 111 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05769153 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Colorado, Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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