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Single Intravitreal (IVT) Injection of 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration
NCT07064759 · View on ClinicalTrials.gov ↗
Study Summary
A Phase 3, Randomized, Double-Masked, Active-Controlled Trial in Adults with Macular Neovascularization Secondary to Age-Related Macular Degeneration
Conditions Studied
Interventions
- BIOLOGICAL 4D-150 IVT (3E10 vg/eye)
- BIOLOGICAL EYLEA® (aflibercept) Injection 2 mg (0.05mL)
Study Locations (20)
California
- Retinal Diagnostic Center — Campbell
- Retina Consultants of Orange County — Fullerton
- West Coast Retina Medical Group — San Francisco
Maryland
- The Retina Care Center — Baltimore
- Cumberland Valley Retina Consultants — Hagerstown
- Mid Atlantic Retina Specialist — Hagerstown
Arizona
- Barnet Dulaney Perkins Eye Center — Sun City
- Retina Associates — Tucson
Florida
- ClearVista Clinical Research — Hudson
- Retina Vitreous Associates of Florida — Tampa
New York
- New York Presbyterian Hospital - Columbia University Medical Center — New York
- Vitreoretinal Consultants of NY — Westbury
South Carolina
- Charleston Neuroscience Institute, LLC — Bluffton
- Carolina Eyecare — Mt. Pleasant
Colorado
- Southwest Retina Consultants — Durango
Georgia
- Thomas Eye Group — Sandy Springs
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 480 participants |
| Start Date | 2025-07-22 |
| Est. Completion | 2029-02 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07064759
The ClinicalTrials.gov registry entry for NCT07064759 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 480 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is 4D Molecular Therapeutics, which has 36 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Neovascular Age-Related Macular Degeneration (nAMD) appearing as the primary indexed condition, and to 2 interventions — of which 4D-150 IVT (3E10 vg/eye) is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT07064759 reports 20 study locations spanning 12 distinct geographic areas — top geographies include California, Maryland, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT07064759 about?
NCT07064759 is a clinical study titled "Single Intravitreal (IVT) Injection of 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration". A Phase 3, Randomized, Double-Masked, Active-Controlled Trial in Adults with Macular Neovascularization Secondary to Age-Related Macular Degeneration
What is the current status of trial NCT07064759?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 480 participants. The study started on 2025-07-22. Estimated completion is 2029-02.
What conditions does trial NCT07064759 study?
This clinical trial studies the following conditions: Neovascular Age-Related Macular Degeneration (nAMD). These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT07064759?
The interventions under investigation include: 4D-150 IVT (3E10 vg/eye) (BIOLOGICAL), EYLEA® (aflibercept) Injection 2 mg (0.05mL) (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT07064759?
This trial is sponsored by 4D Molecular Therapeutics, which has 36 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT07064759 being conducted?
This trial has 20 study locations across Arizona, California, Colorado, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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