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ACTIVE NOT RECRUITING Phase 4

A Study to Determine the Efficacy, Safety, and Durability of Faricimab in Participants With Neovascular Age-Related Macular Degeneration

NCT06795048 · View on ClinicalTrials.gov ↗

Study Summary

This study is a Phase IIIb/IV, multicenter, randomized, two-arm, open-label 100-week study to investigate the efficacy, safety, and durability of intravitreal 6-mg faricimab administered at up to 24-week intervals in patients with neovascular age-related macular degeneration (nAMD) that are treatment-naïve in the study eye.

Interventions

  • DRUG Faricimab

Study Locations (20)

Ontario

  • St. Joseph's Health Care — London
  • Retina Institute of Ottawa — Ottawa
  • Toronto Retina Institute — Toronto

Florida

  • Florida Retina Institute — Orlando
  • Ctr for Retina & Macular Dis — Winter Haven

Illinois

  • Retinal Vitreal Consultants — Chicago
  • University Retina and Macula Associates, PC — Lemont

New South Wales

  • Strathfield Retina Clinic — Strathfield
  • Sydney Eye Hospital — Sydney

Victoria

  • Centre For Eye Research Australia — East Melbourne
  • Retina Specialists Victoria — Rowville

California

  • Orange County Retina Medical Group — Santa Ana

Massachusetts

  • New England Retina Consultants — Springfield

Nevada

  • Sierra Eye Associates — Sparks

Trial Details

FieldValue
Enrollment Target 274 participants
Start Date 2025-03-14
Est. Completion 2027-09-16
Phase Phase 4

Sponsor

Hoffmann-La Roche

758 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06795048

The ClinicalTrials.gov registry entry for NCT06795048 describes a study currently listed as active not recruiting. It is categorized as Phase 4, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 274 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Hoffmann-La Roche, which has 758 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Neovascular Age-related Macular Degeneration (nAMD) appearing as the primary indexed condition, and to 1 intervention — of which Faricimab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06795048 reports 20 study locations spanning 14 distinct geographic areas — top geographies include Ontario, Florida, Illinois. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06795048 about?

NCT06795048 is a clinical study titled "A Study to Determine the Efficacy, Safety, and Durability of Faricimab in Participants With Neovascular Age-Related Macular Degeneration". This study is a Phase IIIb/IV, multicenter, randomized, two-arm, open-label 100-week study to investigate the efficacy, safety, and durability of intravitreal 6-mg faricimab administered at up to 24-week intervals in patients with neovascular age-related macular degeneration (nAMD) that are treatmen...

What is the current status of trial NCT06795048?

This trial is currently active not recruiting. It is a Phase 4 study. The enrollment target is 274 participants. The study started on 2025-03-14. Estimated completion is 2027-09-16.

What conditions does trial NCT06795048 study?

This clinical trial studies the following conditions: Neovascular Age-related Macular Degeneration (nAMD). These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06795048?

The interventions under investigation include: Faricimab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06795048?

This trial is sponsored by Hoffmann-La Roche, which has 758 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06795048 being conducted?

This trial has 20 study locations across California, Florida, Illinois, Massachusetts, Nevada. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial