Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Narcolepsy clinical trials
Every US clinical trial registered for Narcolepsy — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
13 US clinical trials · 4 currently recruiting
The research picture
Narcolepsy has 13 registered US clinical trials, 4 of them open to new participants right now — about 31% of the total.
- 4
- recruiting participants now
- 31%
- of trials open to enrollment
- 3
- in Phase 3–4 (later-stage)
- 5
- top sponsor: Jazz Pharmaceuticals
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
SUNOSI® (Solriamfetol) Pregnancy Registry
Axsome Therapeutics
NCT06413420
WAKIX® (Pitolisant) Pregnancy Registry
Harmony Biosciences Management
NCT05536011
Child and Adolescent Registry for Participants With Narcolepsy
Jazz Pharmaceuticals
NCT04899947
A Study to Investigate Efficacy, Safety, Tolerability, and Pharmacokinetics of JZP441 Compared With Placebo in Participants With Narcolepsy Type 1
Jazz Pharmaceuticals
NCT06961266
Study to Assess Patient Reported Outcomes With Armodafinil Treatment for Excessive Sleepiness in Adults With Narcolepsy or Obstructive Sleep Apnea/Hypopnea Syndrome
Cephalon
NCT00228566
Development and Validation of Pediatric Narcolepsy Patient Reported Outcomes Scale
Boston Children's Hospital
NCT05373979
A Switch Study From High-Sodium Oxybate to XYWAV to Evaluate Changes in Blood Pressure in Participants With Narcolepsy
Jazz Pharmaceuticals
NCT05869773
Study of PROVIGIL ® (Modafinil) Treatment in Children and Adolescents With Excessive Sleepiness Associated With Narcolepsy
Cephalon
NCT00107796
A Study of the Safety and Effectiveness of ADX-N05 for Excessive Daytime Sleepiness in Subjects With Narcolepsy
Jazz Pharmaceuticals
NCT01681121
Observational Study of LUMRYZ in Narcolepsy
Avadel
NCT06792708
Psychosocial Adjunctive Treatment for Hypersomnia (PATH)
Northwestern University
NCT03904238
A Study of the Safety and Effectiveness of ADX-N05 in the Treatment of Excessive Daytime Sleepiness
Jazz Pharmaceuticals
NCT01485770
Narcolepsy Nightmare Study
Northwestern University
NCT05709873
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 2 |
| Phase 3 | 2 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Narcolepsy Trial Landscape
ClinicalTrials.gov lists 13 US studies indexed under Narcolepsy, and 4 of those are currently open to recruitment — roughly 31% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Narcolepsy shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 3 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Narcolepsy is led by Jazz Pharmaceuticals with 5 indexed trials, alongside 6 other organizations in the top contributor list. The list on this page surfaces up to 13 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Narcolepsy?
PlainTrial tracks 13 US clinical trials for Narcolepsy, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Narcolepsy?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.