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ClinicalTrials.gov 4 recruiting now official registry

Narcolepsy clinical trials

4 of 13 indexed Narcolepsy trials are currently recruiting.

13 US clinical trials · 4 currently recruiting

Narcolepsy is the subject of 13 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 3 in Phase 1-2 (earlier-stage). The most active sponsor is Jazz Pharmaceuticals, running 5 of these trials.

The research picture

Narcolepsy has 13 registered US clinical trials, 4 of them open to new participants right now, about 31% of the total.

4
recruiting participants now
31%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
5
top sponsor: Jazz Pharmaceuticals
Phase 11Phase 22Phase 32Phase 41

Active & Recent Trials

13 total, page 1 of 1

RECRUITING 1,731 participants

SUNOSI® (Solriamfetol) Pregnancy Registry

Axsome Therapeutics

NCT06413420

RECRUITING 1,329 participants

WAKIX® (Pitolisant) Pregnancy Registry

Harmony Biosciences Management

NCT05536011

RECRUITING 500 participants

Child and Adolescent Registry for Participants With Narcolepsy

Jazz Pharmaceuticals

NCT04899947

RECRUITING Phase 1 8 participants

A Study to Investigate Efficacy, Safety, Tolerability, and Pharmacokinetics of JZP441 Compared With Placebo in Participants With Narcolepsy Type 1

Jazz Pharmaceuticals

NCT06961266

COMPLETED Phase 3 247 participants

Study to Assess Patient Reported Outcomes With Armodafinil Treatment for Excessive Sleepiness in Adults With Narcolepsy or Obstructive Sleep Apnea/Hypopnea Syndrome

Cephalon

NCT00228566

COMPLETED 212 participants

Development and Validation of Pediatric Narcolepsy Patient Reported Outcomes Scale

Boston Children's Hospital

NCT05373979

COMPLETED Phase 4 160 participants

A Switch Study From High-Sodium Oxybate to XYWAV to Evaluate Changes in Blood Pressure in Participants With Narcolepsy

Jazz Pharmaceuticals

NCT05869773

COMPLETED Phase 3 140 participants

Study of PROVIGIL ® (Modafinil) Treatment in Children and Adolescents With Excessive Sleepiness Associated With Narcolepsy

Cephalon

NCT00107796

COMPLETED Phase 2 93 participants

A Study of the Safety and Effectiveness of ADX-N05 for Excessive Daytime Sleepiness in Subjects With Narcolepsy

Jazz Pharmaceuticals

NCT01681121

COMPLETED 71 participants

Observational Study of LUMRYZ in Narcolepsy

Avadel

NCT06792708

COMPLETED NA 35 participants

Psychosocial Adjunctive Treatment for Hypersomnia (PATH)

Northwestern University

NCT03904238

COMPLETED Phase 2 33 participants

A Study of the Safety and Effectiveness of ADX-N05 in the Treatment of Excessive Daytime Sleepiness

Jazz Pharmaceuticals

NCT01485770

COMPLETED NA 7 participants

Narcolepsy Nightmare Study

Northwestern University

NCT05709873

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 2
Phase 3 2
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Narcolepsy Trial Landscape

13 indexed Narcolepsy studies · 4 recruiting (31%).

Phase mix: 3 late (III/IV) vs 3 early (I/II).

Top sponsor: Jazz Pharmaceuticals (5 trials), 6 others listed. 13 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Narcolepsy?

PlainTrial tracks 13 US clinical trials for Narcolepsy, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Narcolepsy?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.