Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Mitochondrial Disease: early-phase trial registry
3 of 6 indexed Mitochondrial Disease trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #2,866 of 28,707 conditions by registered trial count.
6 US clinical trials · 3 currently recruiting · #2,866 of 28,707 conditions by registered trial count
Mitochondrial Disease: 6 US clinical trials tracked, 3 recruiting.
Mitochondrial Disease is the subject of 6 registered US clinical trials on ClinicalTrials.gov, 3 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is Medical Neurogenetics, running 1 of these trials.
Enrollment posture brief
Registry condition mitochondrial-disease
OPEN 3 | RECR 50% | LATE 0 | EARLY 2 | RANK #2866 | SPON 1
Volume-matched condition peers
Nearest open-share peer: Achalasia (50% recruiting · 8 trials)
Mitochondrial Disease lists 3 open slots (50% of 6 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Mitochondrial Disease on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Mitochondrial Disease is recruiting above its size-band peers.
3 of 6 indexed trials (50%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Mitochondrial Disease research.
Medical Neurogenetics accounts for 1 of 6 trials (16.7%). 6 distinct sponsors appear on at least one study for this condition label.
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Typical Mitochondrial Disease enrolment sits around 102 participants.
Median target enrolment is 102 among the 6 trials that report a genuine target (sentinel values excluded). 3 of those (50%) plan for fewer than 100 participants.
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Mitochondrial Disease splits between interventional and observational designs.
3 interventional and 3 observational studies make up this index (50% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
6 total, page 1 of 1
Acute Infection in Mitochondrial Disease: Metabolism, Infection and Immunity
National Human Genome Research Institute (NHGRI)
NCT04419870
Validation of Nanosensor Oxygen Measurement
Children's Hospital of Philadelphia
NCT06819683
Study of N-acetylcysteine in the Treatment of Patients With the m.3243A>G Mutation and Low Brain Glutathione Levels
Michio Hirano, MD
NCT05241262
Mitochondrial Dysfunction in Autism Spectrum Disorder
University of Arkansas
NCT02000284
Assessment of Small Fiber Neuropathy in Rare Diseases Using Sudoscan
Massachusetts General Hospital
NCT02985710
Mechanisms of Mitochondrial Defects in Gulf War Syndrome
Medical Neurogenetics
NCT01264471
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Mitochondrial Disease records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Mitochondrial Disease trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Mitochondrial Disease page
6 registered trials, 3 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 3 Mitochondrial Disease trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Medical Neurogenetics sponsors the most Mitochondrial Disease trials on record, review their full trial history before evaluating a specific study. See Medical Neurogenetics's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Mitochondrial Disease condition card totals 6 registered trials; most-linked intervention Skin biopsy; top US site state Tennessee. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.