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NCT01264471 · ClinicalTrials.gov registry record
Mechanisms of Mitochondrial Defects in Gulf War Syndrome
A clinical trial of Gulf War Syndrome and Mitochondrial Disease, sponsored by Medical Neurogenetics.
- Completed
- Registry status
- 26
- Enrollment target
- 1
- Study location
NCT01264471: Completed study of Gulf War Syndrome and Mitochondrial Disease, sponsored by Medical Neurogenetics.
NCT01264471 is a study of Gulf War Syndrome and Mitochondrial Disease that has completed, run by Medical Neurogenetics. The registered enrollment target is 26 participants, below the 132-participant average among 8 other Gulf War Syndrome trials with a reported enrollment target (80% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01264471, a study of Gulf War Syndrome and Mitochondrial Disease, has completed, sponsored by Medical Neurogenetics.
- COMPLETED
- Registry status
- 26 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of the study is to investigate possible causes for Gulf War Syndrome. Gulf War Syndrome is associated with increased incidences of amyotrophic lateral sclerosis (Lou Gehrig's Disease), pain syndromes, muscle complaints that include fatigue and myalgias (muscle pain), as well as other neurological symptoms. Abnormalities in the part of the cell known as mitochondria have been delineated in Gulf War Syndrome. Mitochondria are the "power plants" of the body. Mitochondria take the food you eat and break the food down into a form of energy that the body can use. The investigators propose that Gulf War Syndrome is determined by a complex interaction of factors that interfere with mitochondrial function. This study will be the first investigation of mitochondrial function in Gulf War Syndrome. The investigators objective is to establish the cause for symptoms in affected veterans, develop testing that can more easily identify Gulf War Syndrome, and ultimately develop treatment protocols for Gulf War Syndrome.
Primary Outcome
After collecting a skin and blood sample, mitochondrial cellular energetics in Gulf War Syndrome patients will be characterized by: 1. high resolution respirometry of intact cells, 2. quantitative analysis of individual mitochondrial proteins, 3. analysis of intact OXPHOS enzyme complexes and supercomplexes, 4. in gel enzyme activity assessment of intact OXPHOS enzyme complexes and supercomplexes, 5. mitochondrial DNA (mtDNA) copy number quantitation to assess for defects in regulation mtDNA rep
Conditions Studied
Interventions
- PROCEDURE Blood Collection
- PROCEDURE Skin biopsy
Study Locations (1)
Georgia
- Medical Neurogenetics, LLC - Atlanta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 26 participants |
| Start Date | 2009-05 |
| Est. Completion | 2013-06 |
What the finished NCT01264471 record still lists
NCT01264471 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 26 participants, a relatively small participant target, below the 132-participant average among 8 other Gulf War Syndrome trials with a reported enrollment target (80% lower).
The record links to 2 conditions, with Gulf War Syndrome appearing as the primary indexed condition, and to 2 interventions - of which Blood Collection is the first listed.
NCT01264471 reports a single indexed study location in Georgia.
Frequently Asked Questions
What is clinical trial NCT01264471 about?
NCT01264471 is a clinical study titled "Mechanisms of Mitochondrial Defects in Gulf War Syndrome". The purpose of the study is to investigate possible causes for Gulf War Syndrome. Gulf War Syndrome is associated with increased incidences of amyotrophic lateral sclerosis (Lou Gehrig's Disease), pain syndromes, muscle complaints that include fatigue and myalgias (muscle pain), as well as other neu...
What is the current status of trial NCT01264471?
This trial is currently completed. The enrollment target is 26 participants. The study started on 2009-05. Estimated completion is 2013-06.
What conditions does trial NCT01264471 study?
This clinical trial studies the following conditions: Gulf War Syndrome, Mitochondrial Disease.
What interventions are being tested in trial NCT01264471?
The interventions under investigation include: Blood Collection (PROCEDURE), Skin biopsy (PROCEDURE).
Who is sponsoring clinical trial NCT01264471?
This trial is sponsored by Medical Neurogenetics, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01264471 being conducted?
This trial has 1 study location across Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Gulf War Syndrome
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01264471's enrollment target sits among peer trials
26 8th of 8 higher than 1 of 8 other Gulf War Syndrome trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Gulf War Syndrome trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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