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ClinicalTrials.gov 6 recruiting now official registry

Methamphetamine-dependence clinical trials

6 of 19 indexed Methamphetamine-dependence trials are currently recruiting.

19 US clinical trials · 6 currently recruiting

Methamphetamine-dependence is the subject of 19 registered US clinical trials on ClinicalTrials.gov, 6 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 10 in Phase 1-2 (earlier-stage). The most active sponsor is University of California, Los Angeles, running 4 of these trials.

The research picture

Methamphetamine-dependence has 19 registered US clinical trials, 6 of them open to new participants right now, about 32% of the total.

6
recruiting participants now
32%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
4
top sponsor: University of California, Los Angeles
Phase 14Phase 26Phase 32

Active & Recent Trials

19 total, page 1 of 1

RECRUITING NA 600 participants

Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives

Wake Forest University Health Sciences

NCT04927143

RECRUITING Phase 3 360 participants

Trial of Naltrexone/Bupropion for the Treatment of Methamphetamine Use Disorder

National Institute on Drug Abuse (NIDA)

NCT06233799

RECRUITING Phase 2 300 participants

Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders

Evon Medics

NCT06434818

RECRUITING NA 50 participants

rTMS for Craving in Methamphetamine Use Disorder

Oregon Health and Science University

NCT03470480

RECRUITING Early Phase 1 40 participants

PRevention Of Methamphetamine Use Among Postpartum Women Trial (PROMPT)

University of Utah

NCT05128071

RECRUITING Phase 3 29 participants

Creatine for Depressed Male and Female Methamphetamine Users

Montana State University

NCT02568878

ACTIVE NOT RECRUITING NA 40 participants

MHealth Incentivized Adherence Plus Patient Navigation

University of Washington

NCT06027814

ACTIVE NOT RECRUITING NA 30 participants

The Human Stress Response in a Simulated ED Setting

University of Arkansas

NCT04317482

ACTIVE NOT RECRUITING NA 30 participants

Inflammation in Methamphetamine and STIs (IMSTI)

University of California, Los Angeles

NCT05162391

COMPLETED Phase 2 210 participants

Phase 2, Multi-Center Trial of Modafinil for Methamphetamine Dependence

National Institute on Drug Abuse (NIDA)

NCT00520286

COMPLETED Phase 2 84 participants

Study of Medical Treatment for Methamphetamine Addiction

University of California, Los Angeles

NCT00833443

COMPLETED Phase 2 30 participants

PHASE IIA: Trial of a Novel Ondansetron Formulation (OND-PR002) and Immediate-Release Methylphenidate (Ritalin®)(OND003IND)

Tong Lee

NCT01377662

COMPLETED Early Phase 1 24 participants

Targeting GABA and Opioid Systems for a Pharmacotherapy for Methamphetamine Abuse

University of Kentucky

NCT01967381

COMPLETED Phase 2 20 participants

A Trial of Long-Acting Injectable Risperidone in the Treatment of Methamphetamine Dependence

Seattle Institute for Biomedical and Clinical Research

NCT00284206

COMPLETED Phase 2 20 participants

Varenicline vs Placebo for the Treatment of Methamphetamine Dependence

University of California, Los Angeles

NCT01011829

COMPLETED NA 19 participants

Pilot TMS for Methamphetamine Use Disorder

Ryan M. Carnahan

NCT04449055

COMPLETED Phase 1 11 participants

Safety Interaction Trial Ibudilast and Methamphetamine

University of California, Los Angeles

NCT01217970

COMPLETED Phase 1 9 participants

Buspirone as a Candidate Medication for Methamphetamine Abuse

University of Kentucky

NCT01843205

COMPLETED 8 participants

Characterizing Methamphetamine Withdrawal in Recently Abstinent Methamphetamine Users: A Pilot Study

University of Arkansas

NCT00653263

Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 6
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Methamphetamine-dependence Trial Landscape

19 indexed Methamphetamine-dependence studies · 6 recruiting (32%).

Phase mix: 2 late (III/IV) vs 10 early (I/II).

Top sponsor: University of California, Los Angeles (4 trials), 9 others listed. 19 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Methamphetamine-dependence?

PlainTrial tracks 19 US clinical trials for Methamphetamine-dependence, of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Methamphetamine-dependence?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.