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NCT01843205 · ClinicalTrials.gov registry record · Phase 1
Buspirone as a Candidate Medication for Methamphetamine Abuse
A Phase 1 study of Methamphetamine-dependence and Methamphetamine Abuse, sponsored by University of Kentucky.
- Completed
- Registry status
- Phase 1
- Development phase
- 9
- Enrollment target
- 1
- Study location
NCT01843205: Completed Phase 1 study of Methamphetamine-dependence and Methamphetamine Abuse, sponsored by University of Kentucky.
NCT01843205 is a Phase 1 study of Methamphetamine-dependence and Methamphetamine Abuse that has completed, run by University of Kentucky. The registered enrollment target is 9 participants, below the 106-participant average among 18 other Methamphetamine-dependence trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01843205, a Phase 1 study of Methamphetamine-dependence and Methamphetamine Abuse, has completed, sponsored by University of Kentucky.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 9 participants
- Enrollment target
- 1
- Study location
Study Summary
Methamphetamine use disorders are an unrelenting public health concern. Intensive research efforts have yielded behavioral interventions that reduce methamphetamine use, however, these interventions are not universally effective and treatment effects diminish over time. Development of a pharmacotherapy that enhances the efficacy of these interventions is a priority for the National Institute on Drug Abuse. This study proposes to determine the impact of buspirone maintenance on self-administration of methamphetamine. These preliminary data will be used to support further research developing buspirone as a pharmacotherapy for methamphetamine use disorders. The investigators hypothesize that buspirone will attenuate the reinforcing effects of methamphetamine.
Primary Outcome
The reinforcing effects of methamphetamine will be determined during placebo and buspirone treatment using a modified progressive ratio procedure in which subjects are offered the opportunity to earn previously sampled doses of methamphetamine. Each ratio completed on the task will earn 1/10th of the sampled dose.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Methamphetamine
Study Locations (1)
Kentucky
- University of Kentucky Medical Center - Lexington
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 9 participants |
| Start Date | 2013-04 |
| Est. Completion | 2017-03 |
| Phase | Phase 1 |
What the finished NCT01843205 record still lists
NCT01843205 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 9 participants, a relatively small participant target, below the 106-participant average among 18 other Methamphetamine-dependence trials with a reported enrollment target (92% lower).
The record links to 2 conditions, with Methamphetamine-dependence appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT01843205 reports a single indexed study location in Kentucky.
Frequently Asked Questions
What is clinical trial NCT01843205 about?
NCT01843205 is a clinical study titled "Buspirone as a Candidate Medication for Methamphetamine Abuse". Methamphetamine use disorders are an unrelenting public health concern. Intensive research efforts have yielded behavioral interventions that reduce methamphetamine use, however, these interventions are not universally effective and treatment effects diminish over time. Development of a pharmacother...
What is the current status of trial NCT01843205?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 9 participants. The study started on 2013-04. Estimated completion is 2017-03.
What conditions does trial NCT01843205 study?
This clinical trial studies the following conditions: Methamphetamine-dependence, Methamphetamine Abuse.
What interventions are being tested in trial NCT01843205?
The interventions under investigation include: Placebo (DRUG), Methamphetamine (DRUG).
Who is sponsoring clinical trial NCT01843205?
This trial is sponsored by University of Kentucky, which has 54 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01843205 being conducted?
This trial has 1 study location across Kentucky. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Methamphetamine-dependence
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01843205's enrollment target sits among peer trials
9 18th of 18 higher than 1 of 18 other Methamphetamine-dependence trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Methamphetamine-dependence trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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