Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 8 recruiting now official registry

Metastatic Uveal Melanoma clinical trials

8 of 15 indexed Metastatic Uveal Melanoma trials are currently recruiting.

15 US clinical trials · 8 currently recruiting

Metastatic Uveal Melanoma is the subject of 15 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is H. Lee Moffitt Cancer Center and Research Institute, running 3 of these trials.

The research picture

Metastatic Uveal Melanoma has 15 registered US clinical trials, 8 of them open to new participants right now, about 53% of the total.

8
recruiting participants now
53%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
3
top sponsor: H. Lee Moffitt Cancer Center and Research Institute
Phase 17Phase 28

Active & Recent Trials

15 total, page 1 of 1

RECRUITING Phase 1 336 participants

Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions

IDEAYA Biosciences

NCT03947385

RECRUITING Phase 2 280 participants

A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma

Replimune

NCT06581406

RECRUITING Phase 1 109 participants

Tebentafusp-tebn With LDT in Metastatic UM

Thomas Jefferson University

NCT06626516

RECRUITING Phase 1 36 participants

Evaluation of the Safety, Efficacy, and Pharmacokinetics of NBM-BMX in Patients With Metastatic Uveal Melanoma

Novelwise Pharmaceutical Corporation

NCT07136181

RECRUITING Phase 2 32 participants

Study of Cemiplimab Plus Ziv-Aflibercept for Subjects With Metastatic Uveal Melanoma

H. Lee Moffitt Cancer Center and Research Institute

NCT06121180

RECRUITING Phase 2 30 participants

Study of Tebentafusp and Radioembolization in the Treatment of Metastatic Uveal Melanoma

University of Miami

NCT06627244

RECRUITING Phase 1 30 participants

A Study of LN-144 or LN-145 in People With Advanced Uveal Melanoma, Undifferentiated Pleomorphic Sarcoma, or Dedifferentiated Liposarcoma

Memorial Sloan Kettering Cancer Center

NCT05607095

RECRUITING Phase 2 18 participants

Phase 2 Combination of Melphalan/HDS Via PHP + Tebentafusp in Treating Metastatic Uveal Melanoma

H. Lee Moffitt Cancer Center and Research Institute

NCT07276386

ACTIVE NOT RECRUITING Phase 2 420 participants

IDE196 (Darovasertib) in Combination With Crizotinib as First-line Therapy in Metastatic Uveal Melanoma

IDEAYA Biosciences

NCT05987332

ACTIVE NOT RECRUITING Phase 1 352 participants

Study of LVGN3616 and LVGN6051±LVGN7409 in Combination With Nab-Paclitaxel or Bevacizumab and Cyclophosphamide in Metastatic Solid Tumors

M.D. Anderson Cancer Center

NCT05075993

ACTIVE NOT RECRUITING Phase 1 71 participants

Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Disease

M.D. Anderson Cancer Center

NCT03025256

ACTIVE NOT RECRUITING Phase 1 66 participants

A Phase I/II Study of DYP688 in Patients With Metastatic Uveal Melanoma and Other GNAQ/11 Mutant Melanomas

Novartis Pharmaceuticals

NCT05415072

ACTIVE NOT RECRUITING Phase 2 40 participants

Vorinostat in Treating Patients With Metastatic Melanoma of the Eye

National Cancer Institute (NCI)

NCT01587352

ACTIVE NOT RECRUITING Phase 2 28 participants

Transarterial Chemoembolization for the Treatment of Uveal Melanoma With Liver Metastases

Thomas Jefferson University

NCT04728633

ACTIVE NOT RECRUITING Phase 2 7 participants

Binimetinib Plus Belinostat for Subjects With Metastatic Uveal Melanoma

H. Lee Moffitt Cancer Center and Research Institute

NCT05170334

Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Uveal Melanoma Trial Landscape

15 indexed Metastatic Uveal Melanoma studies · 8 recruiting (53%).

Phase mix: 0 late (III/IV) vs 15 early (I/II).

Top sponsor: H. Lee Moffitt Cancer Center and Research Institute (3 trials), 9 others listed. 15 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Uveal Melanoma?

PlainTrial tracks 15 US clinical trials for Metastatic Uveal Melanoma, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Uveal Melanoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.