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ACTIVE NOT RECRUITING Phase 1

Study of LVGN3616 and LVGN6051±LVGN7409 in Combination With Nab-Paclitaxel or Bevacizumab and Cyclophosphamide in Metastatic Solid Tumors

NCT05075993 · View on ClinicalTrials.gov ↗

Study Summary

This is an investigator-initiated industry-supported phase 1 clinical trial conducted in the phase 1 clinic at The University of Texas MD Anderson Cancer Center who will hold the Investigational New Drug (IND). Lvygen Biopharma will provide as investigational supply LVGN3616, LVGN6051 and LVGN7409 at no cost to the patients on this study. This study will explore antitumor activity of four LVGN3616 and LVGN6051 based regimens in seven selected tumor types:

Interventions

  • DRUG LVGN3616 + LVGN6051 + Nab-Paclitaxel
  • DRUG LVGN3616 + LVGN6051 + Bevacizumab + Cyclophosphamide
  • DRUG LVGN3616 + LVGN6051 + LVGN7409 + Nab-Paclitaxel
  • DRUG LVGN3616 + LVGN6051 + LVGN7409 + Bevacizumab + Cyclophosphamide

Study Locations (1)

Texas

  • M D Anderson Cancer Center — Houston

Trial Details

FieldValue
Enrollment Target 352 participants
Start Date 2021-11-12
Est. Completion 2027-02-02
Phase Phase 1

Sponsor

M.D. Anderson Cancer Center

2,992 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05075993

The ClinicalTrials.gov registry entry for NCT05075993 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 352 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is M.D. Anderson Cancer Center, which has 2,992 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 8 conditions, with Gastric Cancer appearing as the primary indexed condition, and to 4 interventions — of which LVGN3616 + LVGN6051 + Nab-Paclitaxel is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05075993 reports 1 study location spanning 1 distinct geographic area — top geographies include Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05075993 about?

NCT05075993 is a clinical study titled "Study of LVGN3616 and LVGN6051±LVGN7409 in Combination With Nab-Paclitaxel or Bevacizumab and Cyclophosphamide in Metastatic Solid Tumors". This is an investigator-initiated industry-supported phase 1 clinical trial conducted in the phase 1 clinic at The University of Texas MD Anderson Cancer Center who will hold the Investigational New Drug (IND). Lvygen Biopharma will provide as investigational supply LVGN3616, LVGN6051 and LVGN7409 a...

What is the current status of trial NCT05075993?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 352 participants. The study started on 2021-11-12. Estimated completion is 2027-02-02.

What conditions does trial NCT05075993 study?

This clinical trial studies the following conditions: Gastric Cancer, Metastatic Uveal Melanoma, Metastatic Hepatocellular Carcinoma, Metastatic Soft Tissue Sarcoma, Metastatic Head and Neck Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05075993?

The interventions under investigation include: LVGN3616 + LVGN6051 + Nab-Paclitaxel (DRUG), LVGN3616 + LVGN6051 + Bevacizumab + Cyclophosphamide (DRUG), LVGN3616 + LVGN6051 + LVGN7409 + Nab-Paclitaxel (DRUG), LVGN3616 + LVGN6051 + LVGN7409 + Bevacizumab + Cyclophosphamide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05075993?

This trial is sponsored by M.D. Anderson Cancer Center, which has 2,992 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05075993 being conducted?

This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial