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ClinicalTrials.gov 10 recruiting now official registry

Metastatic Prostate Adenocarcinoma clinical trials

10 of 19 indexed Metastatic Prostate Adenocarcinoma trials are currently recruiting.

19 US clinical trials · 10 currently recruiting

Metastatic Prostate Adenocarcinoma is the subject of 19 registered US clinical trials on ClinicalTrials.gov, 10 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 17 in Phase 1-2 (earlier-stage). The most active sponsor is Alliance for Clinical Trials in Oncology, running 2 of these trials.

The research picture

Metastatic Prostate Adenocarcinoma has 19 registered US clinical trials, 10 of them open to new participants right now, about 53% of the total.

10
recruiting participants now
53%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
2
top sponsor: Alliance for Clinical Trials in Oncology
Phase 16Phase 211Phase 32

Active & Recent Trials

19 total, page 1 of 1

RECRUITING Phase 3 1,260 participants

Testing the Addition of Docetaxel (Chemotherapy) to the Usual Treatment (Hormonal Therapy and Apalutamide) for Metastatic Prostate Cancer, ASPIRE Trial

Alliance for Clinical Trials in Oncology

NCT06931340

RECRUITING Phase 2 200 participants

Modifying Metabolic Syndrome and Cardiovascular Risk for Prostate Cancer Patients on ADT Using a Risk Factor Modification Program and Continuous Fitbit Monitoring

M.D. Anderson Cancer Center

NCT05054296

RECRUITING Phase 2 70 participants

Talazoparib With Androgen Deprivation Therapy and Abiraterone for the Treatment of Castration Sensitive Prostate Cancer

City of Hope Medical Center

NCT04734730

RECRUITING Phase 2 69 participants

Supraphysiological Androgen to Enhance Treatment Activity in Metastatic Castration-Resistant Prostate Cancer, SPECTRA Study

University of Washington

NCT06039371

RECRUITING Phase 1 48 participants

Cell Therapy (STEAP1 CART) With Enzalutamide for the Treatment of Patients With Metastatic Castration-Resistant Prostate Cancer

Fred Hutchinson Cancer Center

NCT06236139

RECRUITING Phase 2 47 participants

Bipolar Androgen Therapy (BAT) and Radium-223 (RAD) in Metastatic Castration-resistant Prostate Cancer (mCRPC)

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT04704505

RECRUITING Phase 1 39 participants

Ruxolitinib and Enzalutamide for the Treatment of Metastatic Castration-Resistant Prostate Cancer

University of Michigan Rogel Cancer Center

NCT06616155

RECRUITING Phase 2 33 participants

Cabozantinib and Atezolizumab for the Treatment of Metastatic Castration-Resistant Prostate Cancer, The AtezoCab Trial

University of Utah

NCT05168618

RECRUITING Phase 1 30 participants

Abemaciclib Before 177Lu-PSMA-617 for the Treatment of Metastatic Castrate Resistant Prostate Cancer

Vadim S Koshkin

NCT05113537

RECRUITING Phase 2 15 participants

Vorinostat and 177Lu-PSMA-617 for the Treatment of PSMA-Low Metastatic Castration-Resistant Prostate Cancer

Fred Hutchinson Cancer Center

NCT06145633

ACTIVE NOT RECRUITING Phase 1 145 participants

Testing the Safety of Different Doses of Olaparib Given Radium-223 for Men With Advanced Prostate Cancer With Bone Metastasis

National Cancer Institute (NCI)

NCT03317392

ACTIVE NOT RECRUITING Phase 2 84 participants

A Study to Evaluate Hypofractionated Proton Therapy or IMRT for Recurrent, Oligometastatic Prostate Cancer

Mayo Clinic

NCT04190446

ACTIVE NOT RECRUITING Phase 3 61 participants

A Clinical Study Evaluating The Benefit of Adding Rucaparib to Enzalutamide for Men With Metastatic Prostate Cancer That Has Become Resistant To Testosterone-Deprivation Therapy

Alliance for Clinical Trials in Oncology

NCT04455750

ACTIVE NOT RECRUITING Phase 2 61 participants

ZEN-3694, Enzalutamide, and Pembrolizumab for the Treatment of Metastatic Castration-Resistant Prostate Cancer

Rahul Aggarwal

NCT04471974

ACTIVE NOT RECRUITING Phase 2 28 participants

Antiandrogen Therapy and SBRT in Treating Patients With Recurrent, Metastatic Prostate Cancer

Jonsson Comprehensive Cancer Center

NCT03902951

ACTIVE NOT RECRUITING Phase 2 8 participants

CJNJ-67652000 and Prednisone for Treatment of Metastatic Castration-Resistant Prostate Cancer and SPOP Gene Mutations

Mayo Clinic

NCT05689021

ACTIVE NOT RECRUITING Phase 1 7 participants

Cyclophosphamide and Dexamethasone for the Treatment of Metastatic Castration Resistant Prostate Cancer

Rashmi Verma, MD

NCT05479578

COMPLETED Phase 2 36 participants

Genetic and Molecular Mechanisms in Assessing Response in Patients With Prostate Cancer Receiving Enzalutamide Therapy

OHSU Knight Cancer Institute

NCT02099864

COMPLETED Phase 1 16 participants

Evaluation of PSMA Antagonist Produced by Two Different Methods

Weill Medical College of Cornell University

NCT04685811

Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 11
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Prostate Adenocarcinoma Trial Landscape

19 indexed Metastatic Prostate Adenocarcinoma studies · 10 recruiting (53%).

Phase mix: 2 late (III/IV) vs 17 early (I/II).

Top sponsor: Alliance for Clinical Trials in Oncology (2 trials), 9 others listed. 19 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Prostate Adenocarcinoma?

PlainTrial tracks 19 US clinical trials for Metastatic Prostate Adenocarcinoma, of which 10 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Prostate Adenocarcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.