Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
MDD: early-phase trial registry
3 of 8 indexed MDD trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #2,176 of 28,707 conditions by registered trial count.
8 US clinical trials · 3 currently recruiting · #2,176 of 28,707 conditions by registered trial count
MDD: 8 US clinical trials tracked, 3 recruiting.
MDD is the subject of 8 registered US clinical trials on ClinicalTrials.gov, 3 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is University of Texas at Austin, running 1 of these trials.
Enrollment posture brief
Registry condition mdd
OPEN 3 | RECR 38% | LATE 0 | EARLY 1 | RANK #2176 | SPON 1
Volume-matched condition peers
Nearest open-share peer: Acute-graft-versus-host Disease (38% recruiting · 8 trials)
MDD lists 3 open slots (38% of 8 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for MDD on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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MDD is recruiting below its size-band peers.
3 of 8 indexed trials (37.5%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of MDD trials is spread across many organizations.
University of Texas at Austin accounts for 1 of 8 trials (12.5%). 8 distinct sponsors appear on at least one study for this condition label.
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Most MDD trials plan to enrol fewer than 100 people.
Median target enrolment is 40 among the 8 trials that report a genuine target (sentinel values excluded). 5 of those (62.5%) plan for fewer than 100 participants.
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MDD research is mostly interventional.
8 interventional and 0 observational studies make up this index (100% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
8 total, page 1 of 1
Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents
University of Alabama at Birmingham
NCT05437588
Psilocybin rTMS for Treatment Resistant Depression
University of Texas at Austin
NCT06132178
Feasibility of Home-Based Intermittent 60Hz Light Therapy for Major Depressive Disorder (MDD)
NYU Langone Health
NCT07111390
Theta Burst Stimulation for Refractory Depression in Autism Spectrum Disorder
Children's Hospital Medical Center, Cincinnati
NCT06670040
Can Mental Health Apps Work in the Real World? A Feasibility Pilot Study.
University of California, San Francisco
NCT01808976
Extended Reality Behavioral Activation: An Intervention for Major Depressive Disorder
Stanford University
NCT05525390
Mechanism of Action of tACS for the Treatment of MDD
University of North Carolina, Chapel Hill
NCT03994081
Maintenance Transcranial Magnetic Stimulation in Major Depressive Disorder
University of Missouri-Columbia
NCT04076644
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on MDD records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on MDD trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this MDD page
8 registered trials, 3 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 3 MDD trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Texas at Austin sponsors the most MDD trials on record, review their full trial history before evaluating a specific study. See University of Texas at Austin's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This MDD condition card totals 8 registered trials; most-linked intervention Traditional Behavioral Activation; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.