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RECRUITING Phase 3

A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphoma

NCT05100862 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of the study is to compare the efficacy of zanubrutinib plus obinutuzumab versus lenalidomide plus rituximab (R\^2) in participants with relapsed/refractory (R/R) follicular lymphoma (FL), as measured by progression-free survival as determined by an independent review committee in accordance with the 2014 modification of the International Working Group on non-Hodgkin lymphoma (NHL) Criteria based on n positron emission tomography and computed tomography (PET/CT), and to compare the efficacy of zanubrutinib plus rituximab versus R\^2 in participants with R/R marginal zone lymphoma (MZL), as measured by progression free survival (PFS) assessed by IRC in accordance with CT-based Lugano 2014 Criteria.

Interventions

  • DRUG Zanubrutinib
  • DRUG Obinutuzumab
  • DRUG Rituximab
  • DRUG Lenalidomide

Study Locations (20)

California

  • Ucsf Fresno University of California San Francisco Fresno — Fresno
  • Kaiser Permanente Southern California — Irvine
  • Cancer and Blood Specialty Clinic — Los Alamitos
  • Los Angeles Cancer Network — Los Angeles
  • Valkyrie Clinical Trials — Los Angeles
  • UCLA Hematologyoncology — Los Angeles
  • Scripps Health — San Diego
  • Sharp Healthcare Sharp Memorial Hospital — San Diego

Florida

  • Baptist Md Anderson Cancer Center — Jacksonville
  • Ascension Sacred Heart — Pensacola

Kansas

  • Cotton Oneil Cancer Center — Topeka
  • Cancer Center of Kansas — Wichita

Maryland

  • Luminis Health Anne Arundel Medical Center — Annapolis
  • University of Maryland Greenebaum Comprehensive Cancer Center — Baltimore

Georgia

  • Northwest Georgia Oncology Centers Marietta — Marietta

Illinois

  • Cancer Care Specialists of Illinois — Decatur

Indiana

  • Fort Wayne Medical Oncology and Hematology — Fort Wayne

Iowa

  • Mission Cancer and Blood — Waukee

Trial Details

FieldValue
Enrollment Target 780 participants
Start Date 2022-03-10
Est. Completion 2030-06
Phase Phase 3

Sponsor

BeiGene

91 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05100862

The ClinicalTrials.gov registry entry for NCT05100862 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 780 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is BeiGene, which has 91 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Marginal Zone Lymphoma appearing as the primary indexed condition, and to 4 interventions — of which Zanubrutinib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05100862 reports 20 study locations spanning 10 distinct geographic areas — top geographies include California, Florida, Kansas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05100862 about?

NCT05100862 is a clinical study titled "A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphoma". The purpose of the study is to compare the efficacy of zanubrutinib plus obinutuzumab versus lenalidomide plus rituximab (R\^2) in participants with relapsed/refractory (R/R) follicular lymphoma (FL), as measured by progression-free survival as determined by an independent review committee in accord...

What is the current status of trial NCT05100862?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 780 participants. The study started on 2022-03-10. Estimated completion is 2030-06.

What conditions does trial NCT05100862 study?

This clinical trial studies the following conditions: Marginal Zone Lymphoma, Relapsed/Refractory Follicular Lymphoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05100862?

The interventions under investigation include: Zanubrutinib (DRUG), Obinutuzumab (DRUG), Rituximab (DRUG), Lenalidomide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05100862?

This trial is sponsored by BeiGene, which has 91 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05100862 being conducted?

This trial has 20 study locations across California, Florida, Georgia, Illinois, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial