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Lymphedema clinical trials
Every US clinical trial registered for Lymphedema — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
35 US clinical trials · 18 currently recruiting
The research picture
Lymphedema has 35 registered US clinical trials, 18 of them open to new participants right now — about 51% of the total.
- 18
- recruiting participants now
- 51%
- of trials open to enrollment
- 2
- in Phase 3–4 (later-stage)
- 4
- top sponsor: M.D. Anderson Cancer Center
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
A Real-World Registry of Chronic Wounds and Ulcers
U.S. Wound Registry
NCT02280733
Prospective Screening for Breast Cancer-related Lymphedema
Massachusetts General Hospital
NCT01521741
Lymphedema Surveillance Study
Memorial Sloan Kettering Cancer Center
NCT02743858
A Study Comparing Quality of Life in Patients With Lymphedema Who Undergo Surgical Treatment Versus Non-Surgical Management
Memorial Sloan Kettering Cancer Center
NCT03248310
Vascular Lab Resource (VLR) Biorepository
The Cleveland Clinic
NCT05628948
A Post-market, Real-world Experience: Expanding Access to Care by Incorporating the Symani® Surgical System and Enabling Surgeons
MMI (Medical Microinstruments, Inc.)
NCT06725030
Comparing Two Ways to Manage Head and Neck Lymphedema
Abramson Cancer Center at Penn Medicine
NCT05182229
Systemic Therapy of Open-label Prophylactic Pravastatin or Pentoxifylline/Tocopherol Prevention of Lymphedema Advancing to Eventual Fibrosis: an Interventional Registry-embedded Bayesian Randomized Trial for Radiation Sequelae (STOP4-LATE-FIBROSE)
M.D. Anderson Cancer Center
NCT06494111
A Study of a Comprehensive Prevention Program to Reduce Lymphedema After Axillary Lymph Node Dissection in People With Breast Cancer
Memorial Sloan Kettering Cancer Center
NCT06144164
Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)
M.D. Anderson Cancer Center
NCT06912763
Efficacy of GLP-1 Receptor Agonists in Treating Upper and Lower Extremity Lymphedema
Advanced Reconstructive Surgery Alliance
NCT07012642
Clinical Study to Evaluate the Effectiveness and Health Economics of a Novel Portable Non-Pneumatic Active Compression Device (NPCD) for Lymphedema/Phlebolymphedema
Koya Medical
NCT06418282
LYMPHA Procedure for the Prevention of Lymphedema After Axillary Lymphadenectomy
Stanford University
NCT05366699
Pedal Pump and Leg Lymphedema
Rowan University
NCT06235463
Surgical Evaluation for Upper Extremity Lymphedema (BioBridge)
Fibralign Corporation
NCT05695924
LymphBridge: Surgical Evaluation for Breast Cancer-Associated Lymphedema (BioBridge)
Fibralign Corporation
NCT04606030
Lymphedema Prevention Through Immediate Lymphatic Reconstruction (LILY) Trial.
M.D. Anderson Cancer Center
NCT06989099
A Non-randomized, Open-Label Study to Evaluate the Safety and Effectiveness of the Dayspring Technology for Patients With Breast Cancer Related Lymphedema (BCRL) After Lymphatic Surgery
Koya Medical
NCT04888975
PREVENT: PeRomEter Visualization to ENd Treatment-related Lymphedema
M.D. Anderson Cancer Center
NCT05056207
Studying the Physical Function and Quality of Life Before and After Surgery in Patients With Stage I Cervical Cancer
GOG Foundation
NCT01649089
Screening For BCRL In Targeted Therapy For Breast Cancer
Massachusetts General Hospital
NCT05142800
Lymphedema Specific PROs for Risk Assessment, Prevention and Early Detection
University of Miami
NCT05929001
Transcutaneous Sensors for the Detection of Cancer-Related Lymphedema, Project Limb Rescue Study
Ohio State University Comprehensive Cancer Center
NCT06305884
Lymphedema Following Hand/Wrist Surgery in Women Post Axillary Node Dissection
OrthoCarolina Research Institute
NCT00984269
A Study Evaluating an Advanced Pneumatic Compression Device Versus Usual Care for Treatment of Head and Neck Lymphedema
Tactile Medical
NCT04797390
The Impact of Lymphedema on Breast Cancer Survivors
University of California, San Francis
NCT00769821
Enhancing Management of Chronic Pain and Symptoms Among Women Treated for Breast Cancer (Lymph-Flow)
NYU Langone Health
NCT02462226
Skin/Soft Tissue Elasticity in Head and Neck Cancer Survivors With Lymphedema and Fibrosis
Vanderbilt-Ingram Cancer Center
NCT02676752
Lymphedema Prophylaxis in Breast Cancer Survivors Who Show Early Evidence of High-risk Status
Stanford University
NCT00383500
Ubenimex in Adult Patients With Lymphedema of The Lower Limb (ULTRA)
Eiger BioPharmaceuticals
NCT02700529
Low Level Laser Treatment and Breast Cancer Related Lymphedema
Vanderbilt University
NCT00852930
Lymphedema Sensor Technology Development Study
Northwestern University
NCT06778837
A Study of Vascular Endothelial Growth Factor (VEGF) Inhibition in Patients With Unilateral Upper Extremity Lymphedema Following Treatment for Cancer
Kathy Miller
NCT00827372
Intraoperative Evaluation of Axillary Lymphatics
University of Wisconsin, Madison
NCT05094102
Pycnogenol for the Treatment of Lymphedema
University of Wisconsin, Madison
NCT00214032
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 6 |
| Phase 3 | 1 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Lymphedema Trial Landscape
ClinicalTrials.gov lists 35 US studies indexed under Lymphedema, and 18 of those are currently open to recruitment — roughly 51% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Lymphedema shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 7 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Lymphedema is led by M.D. Anderson Cancer Center with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 35 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Lymphedema?
PlainTrial tracks 35 US clinical trials for Lymphedema, of which 18 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Lymphedema?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.