Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Lymphedema: early-phase trial registry
18 of 35 indexed Lymphedema trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #435 of 28,707 conditions by registered trial count.
35 US clinical trials · 18 currently recruiting · #435 of 28,707 conditions by registered trial count
Lymphedema: 35 US clinical trials tracked, 18 recruiting.
Lymphedema is the subject of 35 registered US clinical trials on ClinicalTrials.gov, 18 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 4 of these trials.
Enrollment posture brief
Registry condition lymphedema
OPEN 18 | RECR 51% | LATE 2 | EARLY 7 | RANK #435 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Suicide, Attempted (51% recruiting · 37 trials)
Lymphedema lists 18 open slots (51% of 35 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Lymphedema on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Lymphedema is recruiting above its size-band peers.
18 of 35 indexed trials (51.4%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Lymphedema trials is spread across many organizations.
M.D. Anderson Cancer Center accounts for 4 of 35 trials (11.4%). 25 distinct sponsors appear on at least one study for this condition label.
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Typical Lymphedema enrolment sits around 101 participants.
Median target enrolment is 101 among the 35 trials that report a genuine target (sentinel values excluded). 16 of those (45.7%) plan for fewer than 100 participants.
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Lymphedema splits between interventional and observational designs.
24 interventional and 11 observational studies make up this index (68.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
35 total, page 1 of 1
A Real-World Registry of Chronic Wounds and Ulcers
U.S. Wound Registry
NCT02280733
Prospective Screening for Breast Cancer-related Lymphedema
Massachusetts General Hospital
NCT01521741
Lymphedema Surveillance Study
Memorial Sloan Kettering Cancer Center
NCT02743858
A Study Comparing Quality of Life in Patients With Lymphedema Who Undergo Surgical Treatment Versus Non-Surgical Management
Memorial Sloan Kettering Cancer Center
NCT03248310
Vascular Lab Resource (VLR) Biorepository
The Cleveland Clinic
NCT05628948
A Post-market, Real-world Experience: Expanding Access to Care by Incorporating the Symani® Surgical System and Enabling Surgeons
MMI (Medical Microinstruments, Inc.)
NCT06725030
Comparing Two Ways to Manage Head and Neck Lymphedema
Abramson Cancer Center at Penn Medicine
NCT05182229
Systemic Therapy of Open-label Prophylactic Pravastatin or Pentoxifylline/Tocopherol Prevention of Lymphedema Advancing to Eventual Fibrosis: an Interventional Registry-embedded Bayesian Randomized Trial for Radiation Sequelae (STOP4-LATE-FIBROSE)
M.D. Anderson Cancer Center
NCT06494111
A Study of a Comprehensive Prevention Program to Reduce Lymphedema After Axillary Lymph Node Dissection in People With Breast Cancer
Memorial Sloan Kettering Cancer Center
NCT06144164
Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)
M.D. Anderson Cancer Center
NCT06912763
Efficacy of GLP-1 Receptor Agonists in Treating Upper and Lower Extremity Lymphedema
Advanced Reconstructive Surgery Alliance
NCT07012642
Clinical Study to Evaluate the Effectiveness and Health Economics of a Novel Portable Non-Pneumatic Active Compression Device (NPCD) for Lymphedema/Phlebolymphedema
Koya Medical
NCT06418282
LYMPHA Procedure for the Prevention of Lymphedema After Axillary Lymphadenectomy
Stanford University
NCT05366699
Pedal Pump and Leg Lymphedema
Rowan University
NCT06235463
Surgical Evaluation for Upper Extremity Lymphedema (BioBridge)
Fibralign Corporation
NCT05695924
LymphBridge: Surgical Evaluation for Breast Cancer-Associated Lymphedema (BioBridge)
Fibralign Corporation
NCT04606030
Lymphedema Prevention Through Immediate Lymphatic Reconstruction (LILY) Trial.
M.D. Anderson Cancer Center
NCT06989099
A Non-randomized, Open-Label Study to Evaluate the Safety and Effectiveness of the Dayspring Technology for Patients With Breast Cancer Related Lymphedema (BCRL) After Lymphatic Surgery
Koya Medical
NCT04888975
PREVENT: PeRomEter Visualization to ENd Treatment-related Lymphedema
M.D. Anderson Cancer Center
NCT05056207
Studying the Physical Function and Quality of Life Before and After Surgery in Patients With Stage I Cervical Cancer
GOG Foundation
NCT01649089
Screening For BCRL In Targeted Therapy For Breast Cancer
Massachusetts General Hospital
NCT05142800
Lymphedema Specific PROs for Risk Assessment, Prevention and Early Detection
University of Miami
NCT05929001
Transcutaneous Sensors for the Detection of Cancer-Related Lymphedema, Project Limb Rescue Study
Ohio State University Comprehensive Cancer Center
NCT06305884
Lymphedema Following Hand/Wrist Surgery in Women Post Axillary Node Dissection
OrthoCarolina Research Institute
NCT00984269
A Study Evaluating an Advanced Pneumatic Compression Device Versus Usual Care for Treatment of Head and Neck Lymphedema
Tactile Medical
NCT04797390
The Impact of Lymphedema on Breast Cancer Survivors
University of California, San Francisco
NCT00769821
Enhancing Management of Chronic Pain and Symptoms Among Women Treated for Breast Cancer (Lymph-Flow)
NYU Langone Health
NCT02462226
Skin/Soft Tissue Elasticity in Head and Neck Cancer Survivors With Lymphedema and Fibrosis
Vanderbilt-Ingram Cancer Center
NCT02676752
Lymphedema Prophylaxis in Breast Cancer Survivors Who Show Early Evidence of High-risk Status
Stanford University
NCT00383500
Ubenimex in Adult Patients With Lymphedema of The Lower Limb (ULTRA)
Eiger BioPharmaceuticals
NCT02700529
Low Level Laser Treatment and Breast Cancer Related Lymphedema
Vanderbilt University
NCT00852930
Lymphedema Sensor Technology Development Study
Northwestern University
NCT06778837
A Study of Vascular Endothelial Growth Factor (VEGF) Inhibition in Patients With Unilateral Upper Extremity Lymphedema Following Treatment for Cancer
Kathy Miller
NCT00827372
Intraoperative Evaluation of Axillary Lymphatics
University of Wisconsin, Madison
NCT05094102
Pycnogenol for the Treatment of Lymphedema
University of Wisconsin, Madison
NCT00214032
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 6 |
| Phase 3 | 1 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Lymphedema records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Lymphedema trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Lymphedema page
35 registered trials, 18 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 18 Lymphedema trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- M.D. Anderson Cancer Center sponsors the most Lymphedema trials on record, review their full trial history before evaluating a specific study. See M.D. Anderson Cancer Center's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Lymphedema condition card totals 35 registered trials; most-linked intervention Vascularized Lymph Node Transfer (VLNT); top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.