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NCT06494111 · ClinicalTrials.gov registry record · Phase 2
Systemic Therapy of Open-label Prophylactic Pravastatin or Pentoxifylline/Tocopherol Prevention of Lymphedema Advancing to Eventual Fibrosis: an Interventional Registry-embedded Bayesian Randomized Trial for Radiation Sequelae (STOP4-LATE-FIBROSE)
A Phase 2 study of Lymphedema and Fibrosis, sponsored by M.D. Anderson Cancer Center.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 295
- Enrollment target
- 1
- Study location
NCT06494111: Recruiting Phase 2 study of Lymphedema and Fibrosis, sponsored by M.D. Anderson Cancer Center.
NCT06494111 is a Phase 2 study of Lymphedema and Fibrosis that is actively recruiting participants, run by M.D. Anderson Cancer Center. The registered enrollment target is 295 participants, below the 9,291-participant average among 34 other Lymphedema trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06494111, a Phase 2 study of Lymphedema and Fibrosis, is actively recruiting participants, sponsored by M.D. Anderson Cancer Center.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 295 participants
- Enrollment target
- 1
- Study location
Study Summary
To learn if pentoxifylline and vitamin E or pravastatin can reduce radiation-induced lymphedema/fibrosis.
Primary Outcome
Incidence of Adverse Events, Graded According to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version (v) 5.0
Conditions Studied
Interventions
- DRUG Pentoxifylline
- DRUG Pravastatin
- DRUG Tocopherol
Study Locations (1)
Texas
- MD Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 295 participants |
| Start Date | 2025-02-13 |
| Est. Completion | 2031-03-01 |
| Phase | Phase 2 |
What NCT06494111 shows while recruiting
NCT06494111 is an interventional study that assigns participants to a tested intervention. The registered 295 participants enrollment target is mid-sized for trials with a published cap, below the 9,291-participant average among 34 other Lymphedema trials with a reported enrollment target (97% lower).
The record links to 2 conditions, with Lymphedema appearing as the primary indexed condition, and to 3 interventions - of which Pentoxifylline is the first listed.
NCT06494111 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT06494111 about?
NCT06494111 is a clinical study titled "Systemic Therapy of Open-label Prophylactic Pravastatin or Pentoxifylline/Tocopherol Prevention of Lymphedema Advancing to Eventual Fibrosis: an Interventional Registry-embedded Bayesian Randomized Trial for Radiation Sequelae (STOP4-LATE-FIBROSE)". To learn if pentoxifylline and vitamin E or pravastatin can reduce radiation-induced lymphedema/fibrosis.
What is the current status of trial NCT06494111?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 295 participants. The study started on 2025-02-13. Estimated completion is 2031-03-01.
What conditions does trial NCT06494111 study?
This clinical trial studies the following conditions: Lymphedema, Fibrosis.
What interventions are being tested in trial NCT06494111?
The interventions under investigation include: Pentoxifylline (DRUG), Pravastatin (DRUG), Tocopherol (DRUG).
Who is sponsoring clinical trial NCT06494111?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06494111 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Lymphedema
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06494111's enrollment target sits among peer trials
295 8th of 34 higher than 27 of 34 other Lymphedema trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Lymphedema trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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