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NCT06912763 · ClinicalTrials.gov registry record · Phase 2
Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)
A Phase 2 study of Lymphedema and Fibrosis, sponsored by M.D. Anderson Cancer Center.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 250
- Enrollment target
- 1
- Study location
NCT06912763 is a Phase 2 study of Lymphedema and Fibrosis that is actively recruiting participants, run by M.D. Anderson Cancer Center. The registered enrollment target is 250 participants, below the 9,292-participant average among 34 other Lymphedema trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06912763, a Phase 2 study of Lymphedema and Fibrosis, is actively recruiting participants, sponsored by M.D. Anderson Cancer Center.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 250 participants
- Enrollment target
- 1
- Study location
Study Summary
To find out if adding medication can help treat or prevent lymphedema and/or fibrosis related to radiation therapy, in survivors of head and neck cancer. Researchers will compare these drugs to find the most effective therapy for preventing or limiting these side effects.
Conditions Studied
Interventions
- OTHER Standard of Care (SOC)
- DRUG Pravastatin (drug)
- DRUG Pentoxifylline
- DRUG ketoprofen
- DRUG Pirfenidoneone
Study Locations (1)
Texas
- MD Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 250 participants |
| Start Date | 2025-08-08 |
| Est. Completion | 2033-03-01 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06912763
The ClinicalTrials.gov registry entry for NCT06912763 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 250 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 9,292-participant average among 34 other Lymphedema trials with a reported enrollment target (97% lower). The listed sponsor is M.D. Anderson Cancer Center, which has 2,692 total studies on file at ClinicalTrials.gov.
The record links to 4 conditions, with Lymphedema appearing as the primary indexed condition, and to 5 interventions - of which Standard of Care (SOC) is the first listed.
NCT06912763 reports 1 study location spanning 1 distinct geographic area - top geographies include Texas.
Frequently Asked Questions
What is clinical trial NCT06912763 about?
NCT06912763 is a clinical study titled "Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)". To find out if adding medication can help treat or prevent lymphedema and/or fibrosis related to radiation therapy, in survivors of head and neck cancer. Researchers will compare these drugs to find the most effective therapy for preventing or limiting these side effects.
What is the current status of trial NCT06912763?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 250 participants. The study started on 2025-08-08. Estimated completion is 2033-03-01.
What conditions does trial NCT06912763 study?
This clinical trial studies the following conditions: Lymphedema, Fibrosis, Fibrosis Syndrome, Head &Amp; Neck Cancer.
What interventions are being tested in trial NCT06912763?
The interventions under investigation include: Standard of Care (SOC) (OTHER), Pravastatin (drug) (DRUG), Pentoxifylline (DRUG), ketoprofen (DRUG), Pirfenidoneone (DRUG).
Who is sponsoring clinical trial NCT06912763?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06912763 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.