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NCT06912763 · ClinicalTrials.gov registry record · Phase 2
Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)
A Phase 2 study of Lymphedema and Fibrosis, sponsored by M.D. Anderson Cancer Center.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 250
- Enrollment target
- 1
- Study location
NCT06912763: Recruiting Phase 2 study of Lymphedema and Fibrosis, sponsored by M.D. Anderson Cancer Center.
NCT06912763 is a Phase 2 study of Lymphedema and Fibrosis that is actively recruiting participants, run by M.D. Anderson Cancer Center. The registered enrollment target is 250 participants, below the 9,292-participant average among 34 other Lymphedema trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06912763, a Phase 2 study of Lymphedema and Fibrosis, is actively recruiting participants, sponsored by M.D. Anderson Cancer Center.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 250 participants
- Enrollment target
- 1
- Study location
Study Summary
To find out if adding medication can help treat or prevent lymphedema and/or fibrosis related to radiation therapy, in survivors of head and neck cancer. Researchers will compare these drugs to find the most effective therapy for preventing or limiting these side effects.
Primary Outcome
Incidence of Adverse of Events, Graded According to National Cancer Institute Common Terminology Criteria for Adverse Events
Conditions Studied
Interventions
- OTHER Standard of Care (SOC)
- DRUG Pravastatin (drug)
- DRUG Pentoxifylline
- DRUG ketoprofen
- DRUG Pirfenidoneone
Study Locations (1)
Texas
- MD Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 250 participants |
| Start Date | 2025-08-08 |
| Est. Completion | 2033-03-01 |
| Phase | Phase 2 |
What NCT06912763 shows while recruiting
NCT06912763 is an interventional study that assigns participants to a tested intervention. The registered 250 participants enrollment target is mid-sized for trials with a published cap, below the 9,292-participant average among 34 other Lymphedema trials with a reported enrollment target (97% lower).
The record links to 4 conditions, with Lymphedema appearing as the primary indexed condition, and to 5 interventions - of which Standard of Care (SOC) is the first listed.
NCT06912763 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT06912763 about?
NCT06912763 is a clinical study titled "Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)". To find out if adding medication can help treat or prevent lymphedema and/or fibrosis related to radiation therapy, in survivors of head and neck cancer. Researchers will compare these drugs to find the most effective therapy for preventing or limiting these side effects.
What is the current status of trial NCT06912763?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 250 participants. The study started on 2025-08-08. Estimated completion is 2033-03-01.
What conditions does trial NCT06912763 study?
This clinical trial studies the following conditions: Lymphedema, Fibrosis, Head Neck Cancer, Fibrosis Syndrome.
What interventions are being tested in trial NCT06912763?
The interventions under investigation include: Standard of Care (SOC) (OTHER), Pravastatin (drug) (DRUG), Pentoxifylline (DRUG), ketoprofen (DRUG), Pirfenidoneone (DRUG).
Who is sponsoring clinical trial NCT06912763?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06912763 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Lymphedema
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06912763's enrollment target sits among peer trials
250 11th of 34 higher than 24 of 34 other Lymphedema trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Lymphedema trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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