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ClinicalTrials.gov 15 recruiting now official registry

Lupus Nephritis clinical trials

15 of 31 indexed Lupus Nephritis trials are currently recruiting.

31 US clinical trials · 15 currently recruiting

Lupus Nephritis is the subject of 31 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 21 in Phase 1-2 (earlier-stage). The most active sponsor is Novartis Pharmaceuticals, running 3 of these trials.

The research picture

Lupus Nephritis has 31 registered US clinical trials, 15 of them open to new participants right now, about 48% of the total.

15
recruiting participants now
48%
of trials open to enrollment
6
in Phase 3–4 (later-stage)
3
top sponsor: Novartis Pharmaceuticals
Phase 111Phase 210Phase 35Phase 41

Active & Recent Trials

31 total, page 1 of 1

RECRUITING 3,500 participants

Lupus Landmark Study: A Prospective Registry and Biorepository

Lupus Research Alliance

NCT05934149

RECRUITING 2,000 participants

Repository of Novel Analytes Leading to Autoimmune, Inflammatory and Diabetic Nephropathies (RENAL AID)

The Rogosin Institute

NCT01802034

RECRUITING Phase 3 462 participants

Safety, Efficacy and Tolerability of Ianalumab Versus Placebo, Combination With SoC Therapy, in Participants With Active Lupus Nephritis

Novartis Pharmaceuticals

NCT05126277

RECRUITING 300 participants

Study to Assess Real-world Effectiveness of Belimumab for Treatment of Adults With LN

GlaxoSmithKline

NCT06527872

RECRUITING Phase 2 240 participants

Study of Efficacy and Safety of LNP023 in Participants With Active Lupus Nephritis Class III-IV, +/- V

Novartis Pharmaceuticals

NCT05268289

RECRUITING Phase 2 179 participants

A Study of Rapcabtagene Autoleucel in Active, Refractory Systemic Lupus Erythematosus (SLE) or Lupus Nephritis (LN) Patients (AUTOGRAPH - SLE/LN)

Novartis Pharmaceuticals

NCT06581198

RECRUITING Phase 2 105 participants

The Pediatric Lupus Nephritis Mycophenolate Mofetil (PLUMM) Study

Children's Hospital Medical Center, Cincinnati

NCT05538208

RECRUITING Phase 1 96 participants

A Phase 1/2 Study of NKX019 in Subjects With Autoimmune Disease (Ntrust-1)

Nkarta

NCT06557265

RECRUITING Phase 2 89 participants

A Study of CC-97540 (BMS-986353 or Zola-cel), CD19-Targeted NEX-T CAR T Cells, in Participants With Active SLE Despite Immunosuppressants (Breakfree-SLE)

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

NCT07015983

RECRUITING Phase 1 80 participants

A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease

CRISPR Therapeutics

NCT06925542

RECRUITING Phase 2 74 participants

VIBRANT: VIB4920 for Active Lupus Nephritis

National Institute of Allergy and Infectious Diseases (NIAID)

NCT05201469

RECRUITING Phase 1 47 participants

Phase I/II Study of AD-PluReceptor Plus Tafasitamab-cxix and Lymphodepleting Chemotherapy in Patients With Autoimmune Disorders

M.D. Anderson Cancer Center

NCT06434363

RECRUITING Phase 2 40 participants

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric Participants

Hoffmann-La Roche

NCT05039619

RECRUITING Phase 4 30 participants

Safety and Efficacy of Combination Belimumab and Voclosporin in the Treatment of Proliferative Forms of Lupus Glomerulopathy: Synergy Trial

NephroNet

NCT07225387

RECRUITING Phase 1 28 participants

RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus

Cabaletta Bio

NCT06121297

ACTIVE NOT RECRUITING Phase 3 359 participants

Phase 3 Study of Anifrolumab in Adult Patients With Active Proliferative Lupus Nephritis

AstraZeneca

NCT05138133

ACTIVE NOT RECRUITING Phase 3 271 participants

A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With ISN/RPS 2003 Class III or IV Lupus Nephritis

Hoffmann-La Roche

NCT04221477

ACTIVE NOT RECRUITING Phase 1 72 participants

An Open-label Study of Povetacicept in Autoantibody-Associated Glomerular Diseases

Alpine Immune Sciences

NCT05732402

ACTIVE NOT RECRUITING Phase 1 48 participants

A Phase 1 Study of SYNCAR-001 + STK-009 Without Conditioning Chemotherapy (Lymphodepletion) in Subjects With Severe, Refractory Systemic Autoimmune Rheumatic Disease

Synthekine

NCT06544330

ACTIVE NOT RECRUITING Phase 1 14 participants

A Study to Learn More About the Safety and Effects of Felzartamab in Adults With Lupus Nephritis Aged 18 to 75 Years Old

HI-Bio, A Biogen Company

NCT06064929

ACTIVE NOT RECRUITING Phase 2 12 participants

Daratumumab to Treat Active Lupus Nephritis

Mayo Clinic

NCT04868838

ACTIVE NOT RECRUITING Phase 1 6 participants

KYSA-1: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell (CD19 CAR T) Therapy, in Subjects With Refractory Lupus Nephritis

Kyverna Therapeutics

NCT05938725

ACTIVE NOT RECRUITING Phase 1 6 participants

A Study of CNTY-101 in Participants With Refractory B Cell-mediated Autoimmune Diseases

Century Therapeutics

NCT06255028

COMPLETED Phase 3 448 participants

Efficacy and Safety of Belimumab in Patients With Active Lupus Nephritis

Human Genome Sciences Inc., a GSK Company

NCT01639339

COMPLETED Phase 3 358 participants

Aurinia Renal Response in Active Lupus With Voclosporin

Aurinia Pharmaceuticals

NCT03021499

COMPLETED NA 166 participants

Establishing Clinical Utility of a New Diagnostic Test for Rheumatology Patients

Qure Healthcare

NCT04266860

COMPLETED Phase 2 121 participants

Dose Finding, Efficacy and Safety of BI 655064 in Patients With Active Lupus Nephritis

Boehringer Ingelheim

NCT02770170

COMPLETED Phase 1 69 participants

A Study of KZR-616 in Patients With SLE With and Without Lupus Nephritis

Kezar Life Sciences

NCT03393013

COMPLETED Phase 2 46 participants

A Study of Laquinimod in Participants With Systemic Lupus Erythematosus (SLE) Active Lupus Nephritis

Teva Branded Pharmaceutical Products R&D

NCT01085097

COMPLETED Phase 1 22 participants

Phase Ib Study of SC Milatuzumab in SLE

Gilead Sciences

NCT01845740

COMPLETED Phase 2 21 participants

Phase II Study Assessing Safety and Efficacy of APL-2 in Glomerulopathies

Apellis Pharmaceuticals

NCT03453619

Phase Distribution

PhaseTrial count
Phase 1 11
Phase 2 10
Phase 3 5
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Lupus Nephritis Trial Landscape

31 indexed Lupus Nephritis studies · 15 recruiting (48%).

Phase mix: 6 late (III/IV) vs 21 early (I/II).

Top sponsor: Novartis Pharmaceuticals (3 trials), 9 others listed. 31 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Lupus Nephritis?

PlainTrial tracks 31 US clinical trials for Lupus Nephritis, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Lupus Nephritis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.