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A Phase 1/2 Study of NKX019 in Subjects With Autoimmune Disease (Ntrust-1)
NCT06557265 · View on ClinicalTrials.gov ↗
Study Summary
This is an open-label, multi-center, non-randomized, Phase 1/2 study to determine the safety and tolerability of NKX019 (allogeneic CAR NK cells targeting CD19) in participants with active lupus nephritis (LN) or primary membranous nephropathy (pMN).
Conditions Studied
Interventions
- DRUG NKX019
- DRUG Fludarabine, Cyclophosphamide
Study Locations (16)
Florida
- Nkarta Investigational Site — Gainesville
- Nkarta Investigational Site — Miami
- Nkarta Investigational Site — Plantation
- Nkarta Investigational Site — Tampa
New York
- Nkarta Investigational Site — New York
- Nkarta Investigational Site — Stony Brook
- Nkarta Investigational Site — Syracuse
Texas
- Nkarta Investigational Site — Dallas
- Nkarta Investigational Site — Houston
Arkansas
- Nkarta Investigational Site — Little Rock
Georgia
- Nkarta Investigational Site — Atlanta
Illinois
- Nkarta Investigational Site — Chicago
Louisiana
- Nkarta Investigational Site — New Orleans
Massachusetts
- Nkarta Investigational Site — Worcester
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 96 participants |
| Start Date | 2024-06-13 |
| Est. Completion | 2027-04 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06557265
The ClinicalTrials.gov registry entry for NCT06557265 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 96 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Nkarta, which has 4 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Lupus Nephritis appearing as the primary indexed condition, and to 2 interventions — of which NKX019 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06557265 reports 16 study locations spanning 10 distinct geographic areas — top geographies include Florida, New York, Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06557265 about?
NCT06557265 is a clinical study titled "A Phase 1/2 Study of NKX019 in Subjects With Autoimmune Disease (Ntrust-1)". This is an open-label, multi-center, non-randomized, Phase 1/2 study to determine the safety and tolerability of NKX019 (allogeneic CAR NK cells targeting CD19) in participants with active lupus nephritis (LN) or primary membranous nephropathy (pMN).
What is the current status of trial NCT06557265?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 96 participants. The study started on 2024-06-13. Estimated completion is 2027-04.
What conditions does trial NCT06557265 study?
This clinical trial studies the following conditions: Lupus Nephritis, Primary Membranous Nephropathy. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06557265?
The interventions under investigation include: NKX019 (DRUG), Fludarabine, Cyclophosphamide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06557265?
This trial is sponsored by Nkarta, which has 4 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06557265 being conducted?
This trial has 16 study locations across Arkansas, Florida, Georgia, Illinois, Louisiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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