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ACTIVE NOT RECRUITING Phase 1

A Study of CNTY-101 in Participants With Refractory B Cell-mediated Autoimmune Diseases

NCT06255028 · View on ClinicalTrials.gov ↗

Study Summary

CALiPSO-1 is a Phase 1, multi-centre, dose-confirmation study to evaluate the safety and efficacy of CNTY-101 in participants with refractory B cell-mediated autoimmune diseases including those with moderate to severe systemic lupus erythematosus (SLE) with or without lupus nephritis (LN), idiopathic inflammatory myopathies (IIM), and diffuse cutaneous systemic sclerosis (DcSSc).

Interventions

  • BIOLOGICAL CNTY-101
  • BIOLOGICAL IL-2
  • DRUG Lymphodepleting Chemotherapy

Study Locations (6)

California

  • Keck School of Medicine of University of Southern California — Los Angeles
  • UC Davis — Sacramento

Illinois

  • Lurie Children's; Northwestern Medicine - Northwestern Medical Group — Chicago

Texas

  • Texas Children's Hospital — Houston

Utah

  • Primary Children's Hospital — Salt Lake City

Washington

  • Fred Hutch — Seattle

Trial Details

FieldValue
Enrollment Target 6 participants
Start Date 2025-02-06
Est. Completion 2028-08
Phase Phase 1

Sponsor

Century Therapeutics

2 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06255028

The ClinicalTrials.gov registry entry for NCT06255028 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 6 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Century Therapeutics, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 4 conditions, with Systemic Lupus Erythematosus appearing as the primary indexed condition, and to 3 interventions — of which CNTY-101 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06255028 reports 6 study locations spanning 5 distinct geographic areas — top geographies include California, Illinois, Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06255028 about?

NCT06255028 is a clinical study titled "A Study of CNTY-101 in Participants With Refractory B Cell-mediated Autoimmune Diseases". CALiPSO-1 is a Phase 1, multi-centre, dose-confirmation study to evaluate the safety and efficacy of CNTY-101 in participants with refractory B cell-mediated autoimmune diseases including those with moderate to severe systemic lupus erythematosus (SLE) with or without lupus nephritis (LN), idiopathi...

What is the current status of trial NCT06255028?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 6 participants. The study started on 2025-02-06. Estimated completion is 2028-08.

What conditions does trial NCT06255028 study?

This clinical trial studies the following conditions: Systemic Lupus Erythematosus, Lupus Nephritis, Idiopathic Inflammatory Myopathies, Diffuse Cutaneous Systemic Sclerosis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06255028?

The interventions under investigation include: CNTY-101 (BIOLOGICAL), IL-2 (BIOLOGICAL), Lymphodepleting Chemotherapy (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06255028?

This trial is sponsored by Century Therapeutics, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06255028 being conducted?

This trial has 6 study locations across California, Illinois, Texas, Utah, Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial