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ClinicalTrials.gov 14 recruiting now official registry

Low Grade Glioma clinical trials

14 of 24 indexed Low Grade Glioma trials are currently recruiting.

24 US clinical trials · 14 currently recruiting

Low Grade Glioma is the subject of 24 registered US clinical trials on ClinicalTrials.gov, 14 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 4 of these trials.

The research picture

Low Grade Glioma has 24 registered US clinical trials, 14 of them open to new participants right now, about 58% of the total.

14
recruiting participants now
58%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
4
top sponsor: National Cancer Institute (NCI)
Phase 19Phase 26Phase 34

Active & Recent Trials

24 total, page 1 of 1

RECRUITING Phase 3 400 participants

DAY101 vs. Standard of Care Chemotherapy in Pediatric Participants With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2)

Day One Biopharmaceuticals

NCT05566795

RECRUITING Phase 2 200 participants

Post-Operative Dosing of Dexamethasone in Patients With Brain Tumors After a Craniotomy, PODS Trial

Emory University

NCT06132685

RECRUITING Phase 3 170 participants

A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

National Cancer Institute (NCI)

NCT04166409

RECRUITING Phase 2 141 participants

A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors

Day One Biopharmaceuticals

NCT04775485

RECRUITING Phase 1 132 participants

SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma

St. Jude Children's Research Hospital

NCT04923126

RECRUITING NA 125 participants

HOBSCOTCH-CA (HOme-Based Self-management and COgnitive Training CHanges Lives in Brain CAncer)

Dartmouth-Hitchcock Medical Center

NCT06930846

RECRUITING Phase 1 124 participants

A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors

Pfizer

NCT05538130

RECRUITING NA 97 participants

Rehabilitation and Longitudinal Follow-up of Cognition in Adult Lower Grade Gliomas

University of California, San Francisco

NCT03948490

RECRUITING Phase 2 96 participants

Dabrafenib and Trametinib for BRAF V600 Mutant Low-Grade Gliomas

University of California, San Francisco

NCT07110246

RECRUITING Phase 1 50 participants

Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)

University of California, San Francisco

NCT04485559

RECRUITING Early Phase 1 30 participants

Evaluation of 18F-Fluciclovine Positron Emission Tomography - Magnetic Resonance Imaging (PET-MRI) in LGG

Children's Hospital of Philadelphia

NCT05555550

RECRUITING Phase 1 27 participants

MAPK Inhibition Combined With Anti-PD1 Therapy for BRAF-altered Pediatric Gliomas

Ann & Robert H Lurie Children's Hospital of Chicago

NCT06712875

RECRUITING Phase 2 25 participants

A Vaccine Trial for Low Grade Gliomas

James Felker

NCT02358187

RECRUITING Phase 1 23 participants

A Study of Avutometinib for People With Solid Tumor Cancers

Memorial Sloan Kettering Cancer Center

NCT06104488

ACTIVE NOT RECRUITING Phase 1 217 participants

Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma

National Cancer Institute (NCI)

NCT01089101

ACTIVE NOT RECRUITING Phase 3 165 participants

A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromatosis and Low-Grade Glioma

National Cancer Institute (NCI)

NCT03871257

ACTIVE NOT RECRUITING Phase 2 109 participants

Vinblastine +/- Bevacizumab in Children With Unresectable or Progressive Low Grade Glioma (LGG)

The Hospital for Sick Children

NCT02840409

ACTIVE NOT RECRUITING 100 participants

Seizure Control as a New Metric in Assessing Efficacy of Tumor Treatment in Patients With Low Grade Glioma

M.D. Anderson Cancer Center

NCT04553757

ACTIVE NOT RECRUITING Phase 3 95 participants

A Study Comparing Two Carboplatin Containing Regimens for Children and Young Adults With Previously Untreated Low Grade Glioma

Alicia Lenzen

NCT02455245

ACTIVE NOT RECRUITING Phase 1 78 participants

BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas

University of California, San Francisco

NCT03749187

ACTIVE NOT RECRUITING NA 74 participants

Mind-Body Intervention in Glioma Couples

M.D. Anderson Cancer Center

NCT03244995

ACTIVE NOT RECRUITING NA 63 participants

Proton Radiation Therapy for Gliomas

Massachusetts General Hospital

NCT01358058

ACTIVE NOT RECRUITING Phase 2 62 participants

Nivolumab in Patients With IDH-Mutant Gliomas With and Without Hypermutator Phenotype

National Cancer Institute (NCI)

NCT03718767

ACTIVE NOT RECRUITING Early Phase 1 16 participants

Niraparib In Recurrent IDH 1/2 Gliomas

Massachusetts General Hospital

NCT05406700

Phase Distribution

PhaseTrial count
Phase 1 9
Phase 2 6
Phase 3 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Low Grade Glioma Trial Landscape

24 indexed Low Grade Glioma studies · 14 recruiting (58%).

Phase mix: 4 late (III/IV) vs 15 early (I/II).

Top sponsor: National Cancer Institute (NCI) (4 trials), 9 others listed. 24 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Low Grade Glioma?

PlainTrial tracks 24 US clinical trials for Low Grade Glioma, of which 14 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Low Grade Glioma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.