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ClinicalTrials.gov 14 recruiting now official registry

Liver Metastases clinical trials

Every US clinical trial registered for Liver Metastases — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

28 US clinical trials · 14 currently recruiting

The research picture

Liver Metastases has 28 registered US clinical trials, 14 of them open to new participants right now — about 50% of the total.

14
recruiting participants now
50%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
2
top sponsor: Roger Williams Medical Center

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING NA 397 participants

Stereotactic Magnetic Resonance Guided Radiation Therapy

Dana-Farber Cancer Institute

NCT04115254

RECRUITING Phase 2 200 participants

Tissue Analysis After Tumor Ablation for Liver Metastases Leading to Immediate Retreatment

Memorial Sloan Kettering Cancer Center

NCT04143516

RECRUITING Phase 2 120 participants

ctDNA-Directed Post-Hepatectomy Chemotherapy for Patients With Resectable Colorectal Liver Metastases

M.D. Anderson Cancer Center

NCT05062317

RECRUITING NA 100 participants

Histotripsy Plus Chemotherapy vs Chemotherapy Alone for Advanced Colorectal Liver Metastasis

Case Comprehensive Cancer Center

NCT07044362

RECRUITING Phase 2 62 participants

REGULUS: MRI-guided Adaptive SABR for Liver Cancers

Stanford University

NCT07223307

RECRUITING NA 40 participants

HepQuant: Study to Assess the Role of Blood-based Biomarkers and Quantitative MR Imaging for Patients Receiving Radiation Therapy for Liver Cancer

Montefiore Medical Center

NCT06899152

RECRUITING Phase 2 39 participants

Study of Bevacizumab in Combination With Chemoimmunotherapy and Atezolizumab in Patients With Extensive Stage Small Cell Lung Cancer and Liver Metastases

Kamya Sankar

NCT05588388

RECRUITING NA 35 participants

Proton Therapy in the Treatment of Liver Metastases

Loma Linda University

NCT01697371

RECRUITING Phase 2 32 participants

A Study of Single Fraction Stereotactic Body Radiation Therapy (SBRT) Guided by Magnetic Resonance Imaging (MRI) in People With Liver Metastasis From Colorectal Cancer

Memorial Sloan Kettering Cancer Center

NCT06130280

RECRUITING NA 32 participants

OAR-Based, Dose Escalated SBRT With Real Time Adaptive MRI Guidance for Liver Metastases

University of Wisconsin, Madison

NCT04020276

RECRUITING Phase 2 24 participants

Platform Study of Immunotherapy Combinations in Colorectal Cancer Liver Metastases

Weill Medical College of Cornell University

NCT06300463

RECRUITING NA 21 participants

Promoting Immunotherapy Efficacy With Low-Dose Liver RT

Jordan Kharofa

NCT07225036

RECRUITING Phase 1 15 participants

Hepzato Kit and Opdualag for Metastatic Melanoma and Liver Metastasis

University of Wisconsin, Madison

NCT07281924

RECRUITING Phase 1 12 participants

Liver SBRT in Combination With Immune Checkpoint Inhibition in Patients With Metastatic Non-small Cell Lung Cancer

VA Ann Arbor Healthcare System

NCT05430009

ACTIVE NOT RECRUITING NA 146 participants

Lesion Detection Assessment in the Liver: Standard vs Low Radiation Dose Using Varied Post-Processing Techniques

M.D. Anderson Cancer Center

NCT03151564

ACTIVE NOT RECRUITING NA 47 participants

The HistoSonics System for Treatment of Primary and Metastatic Liver Tumors Using Histotripsy

HistoSonics

NCT04572633

ACTIVE NOT RECRUITING NA 25 participants

Senior Adult Hepatobiliary Prehab Study

H. Lee Moffitt Cancer Center and Research Institute

NCT05921552

ACTIVE NOT RECRUITING 18 participants

Hepatic Resection for Metastatic Pancreatic Cancer

Duke University

NCT02892305

ACTIVE NOT RECRUITING Phase 2 14 participants

Hepatic Artery Infusional Floxuridine to Treat Pancreatic Cancer Liver Metastases

Corewell Health West

NCT03856658

ACTIVE NOT RECRUITING NA 10 participants

Copper Cu 64-DOTA-Trastuzumab PET in Predicting Response to Treatment With Ado-Trastuzumab Emtansine in Patients With Metastatic HER2 Positive Breast Cancer

City of Hope Medical Center

NCT02226276

ACTIVE NOT RECRUITING 6 participants

Pilot Study to Assess Lung Shunting of Yttrium-90 Microspheres Using PET/CT

University of Cincinnati

NCT02119065

COMPLETED NA 261 participants

Comprehensive Electronic Cancer Support System for the Treatment of Cancer Related Symptoms

University of Pittsburgh

NCT01640522

COMPLETED NA 92 participants

Individualized Stereotactic Body Radiotherapy of Liver Metastases

Massachusetts General Hospital

NCT01239381

COMPLETED Phase 1 55 participants

A Study Evaluating Safety, Pharmacokinetics, Pharmacodynamics, And Clinical Activity Of RO7119929 (TLR7 Agonist) In Participants With Unresectable Advanced Or Metastatic Hepatocellular Carcinoma, Biliary Tract Cancer, Or Solid Tumors With Hepatic Metastases

Hoffmann-La Roche

NCT04338685

COMPLETED Phase 1 16 participants

Hepatic Arterial Infusion of Floxuridine, Gemcitabine Hydrochloride, and Radiolabeled Monoclonal Antibody Therapy in Treating Liver Metastases in Patients With Metastatic Colorectal Cancer Previously Treated With Surgery

City of Hope Medical Center

NCT00645710

COMPLETED Phase 1 8 participants

CAR-T Hepatic Artery Infusions and Sir-Spheres for Liver Metastases

Roger Williams Medical Center

NCT02416466

COMPLETED Phase 1 5 participants

CAR-T Hepatic Artery Infusions or Pancreatic Venous Infusions for CEA-Expressing Liver Metastases or Pancreas Cancer

Roger Williams Medical Center

NCT02850536

COMPLETED 4 participants

Hypofractionated Image Guided Radiation Therapy in Treating Patients With Stage IV Breast Cancer

University of Chicago

NCT01706432

Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Liver Metastases Trial Landscape

ClinicalTrials.gov lists 28 US studies indexed under Liver Metastases, and 14 of those are currently open to recruitment — roughly 50% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Liver Metastases shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 13 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Liver Metastases is led by Roger Williams Medical Center with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 28 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Liver Metastases?

PlainTrial tracks 28 US clinical trials for Liver Metastases, of which 14 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Liver Metastases?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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