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ClinicalTrials.gov 9 recruiting now official registry

Leiomyosarcoma clinical trials

9 of 17 indexed Leiomyosarcoma trials are currently recruiting.

17 US clinical trials · 9 currently recruiting

Leiomyosarcoma is the subject of 17 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 11 in Phase 1-2 (earlier-stage). The most active sponsor is University of Michigan Rogel Cancer Center, running 2 of these trials.

The research picture

Leiomyosarcoma has 17 registered US clinical trials, 9 of them open to new participants right now, about 53% of the total.

9
recruiting participants now
53%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
2
top sponsor: University of Michigan Rogel Cancer Center
Phase 14Phase 27Phase 33

Active & Recent Trials

17 total, page 1 of 1

RECRUITING Phase 3 450 participants

Study of Lurbinectedin in Combination With Doxorubicin Versus Doxorubicin Alone as First-line Treatment in Participants With Metastatic Leiomyosarcoma (SaLuDo)

PharmaMar

NCT06088290

RECRUITING Phase 3 325 participants

Phase III Trial of Anlotinib, Catequentinib in Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma (APROMISS)

Advenchen Laboratories

NCT03016819

RECRUITING 300 participants

Beliefs, Attitudes, and Response to Genetic Testing in SarcomaPatients

University of Utah

NCT06875700

RECRUITING Phase 3 250 participants

Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma

European Organisation for Research and Treatment of Cancer - EORTC

NCT04031677

RECRUITING 200 participants

Metastatic Leiomyosarcoma Biomarker Protocol

University of Michigan Rogel Cancer Center

NCT05653388

RECRUITING Phase 2 80 participants

Metronomic Trabectedin, Gemcitabine, and Dacarbazine for Soft Tissue Sarcoma

Sarcoma Oncology Research Center

NCT04535271

RECRUITING 40 participants

Localized Leiomyosarcoma Biomarker Protocol

University of Michigan Rogel Cancer Center

NCT04925089

RECRUITING Phase 1 18 participants

A Phase I Trial of Combination Gemcitabine and Nab-Sirolimus in Advanced Leiomyosarcomas or Advanced Soft-Tissue Sarcomas With TSC2 or TSC1 Loss-of-function Mutations or Deletions

M.D. Anderson Cancer Center

NCT06308419

RECRUITING Phase 2 16 participants

Study of All-Trans Retinoic Acid (ATRA) and Cemiplimab in Patients With Advanced Leiomyosarcoma

Gabriel Tino

NCT06528769

ACTIVE NOT RECRUITING Phase 2 40 participants

Talimogene Laherparepvec and Radiation Therapy in Treating Patients With Newly Diagnosed Soft Tissue Sarcoma That Can Be Removed by Surgery

National Cancer Institute (NCI)

NCT02923778

ACTIVE NOT RECRUITING Phase 2 20 participants

A Study of Rucaparib and Nivolumab in People With Leiomyosarcoma

Memorial Sloan Kettering Cancer Center

NCT04624178

ACTIVE NOT RECRUITING Phase 1 14 participants

Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma

Jonsson Comprehensive Cancer Center

NCT04420975

COMPLETED Phase 1 74 participants

LMP-specific T-cells for Patients With Relapsed EBV-positive Lymphoma

Baylor College of Medicine

NCT00062868

COMPLETED Phase 1 41 participants

A Study of Unesbulin (PTC596) in Combination With Dacarbazine in Participants With Advanced Leiomyosarcoma (LMS)

PTC Therapeutics

NCT03761095

COMPLETED Phase 2 35 participants

A Study of Nivolumab in Selected Uterine Cancer Patients

Memorial Sloan Kettering Cancer Center

NCT03241745

COMPLETED Phase 2 27 participants

Letrozole in Women With Advanced Estrogen/Progesterone Receptor Positive Uterine Leiomyosarcoma

Dana-Farber Cancer Institute

NCT00856050

COMPLETED Phase 2 20 participants

Bevacizumab and Radiation Therapy for Sarcomas

Massachusetts General Hospital

NCT00356031

Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 7
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Leiomyosarcoma Trial Landscape

17 indexed Leiomyosarcoma studies · 9 recruiting (53%).

Phase mix: 3 late (III/IV) vs 11 early (I/II).

Top sponsor: University of Michigan Rogel Cancer Center (2 trials), 9 others listed. 17 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Leiomyosarcoma?

PlainTrial tracks 17 US clinical trials for Leiomyosarcoma, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Leiomyosarcoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.