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ClinicalTrials.gov 5 recruiting now later-stage tilt small index

Leg Ulcer: later-stage trial registry

5 of 9 indexed Leg Ulcer trials are currently recruiting, with more weight in Phase 3-4.

Corpus placement: #1,916 of 28,707 conditions by registered trial count.

9 US clinical trials · 5 currently recruiting · #1,916 of 28,707 conditions by registered trial count

Leg Ulcer: 9 US clinical trials tracked, 5 recruiting.

Leg Ulcer is the subject of 9 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is C5 Biomedical, running 1 of these trials.

Enrollment posture brief

Registry condition leg-ulcer

OPEN 5 | RECR 56% | LATE 3 | EARLY 1 | RANK #1916 | SPON 1

Nearest open-share peer: Advanced Colorectal Cancer (56% recruiting · 9 trials)

Leg Ulcer (this)56%Acute Lymphoblastic Leukemia55.6%Acute Respiratory Distress S55.6%Acute Otitis Media22.2%Acute Heart Failure11.1%
Open-enrollment share among volume-matched conditions near Leg Ulcer

Leg Ulcer lists 5 open slots (56% of 9 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Leg Ulcer on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Leg Ulcer is recruiting above its size-band peers.

    5 of 9 indexed trials (55.6%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. Sponsorship of Leg Ulcer trials is spread across many organizations.

    C5 Biomedical accounts for 1 of 9 trials (11.1%). 9 distinct sponsors appear on at least one study for this condition label.

  3. Typical Leg Ulcer enrolment sits around 177 participants.

    Median target enrolment is 177 among the 9 trials that report a genuine target (sentinel values excluded). 3 of those (33.3%) plan for fewer than 100 participants.

  4. Leg Ulcer research is mostly interventional.

    8 interventional and 1 observational studies make up this index (88.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 21Phase 43

Open and recent trials

9 total, page 1 of 1

RECRUITING 300,000 participants

A Real-World Registry of Chronic Wounds and Ulcers

U.S. Wound Registry

NCT02280733

RECRUITING Phase 4 650 participants

Trial Assessing the Efficacy of Human Placental Membrane Products and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers

BioLab Holdings

NCT07089602

RECRUITING Phase 4 340 participants

Evaluating Several Cellular, Acellular, and Matrix-like Products (CAMPs) and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot and Venous Leg Ulcers.

Tiger Biosciences

NCT06826339

RECRUITING NA 324 participants

Modified Multi-Platform Trial Assessing Multiple CAMPs and SOC vs SOC Alone in the Treatment of DFU and VLUs

Stability Biologics

NCT06560502

RECRUITING NA 177 participants

Clinical Trial Assessing Human Placental Membrane Products and Standard of Care Versus Standard of Care in Nonhealing DFUs and VLUs

C5 Biomedical

NCT06674980

COMPLETED Phase 2 140 participants

Cooling Leg and Foot Ulcer Skin Post Healing to Prevent Ulcer Recurrence

Medical University of South Carolina

NCT02626156

COMPLETED NA 48 participants

Evaluating the Safety and Efficacy of Fractionated Carbon Dioxide Therapy in Postoperative Lower Extremity Wound Healing

St. Louis University

NCT03644849

COMPLETED Phase 4 48 participants

A Study to Evaluate the Clinical Effectiveness of a Collagen-ORC Antimicrobial Matrix in Venous Leg Ulcers

Ethicon

NCT00235209

COMPLETED NA 40 participants

Evaluation Of An Advanced Borderless Dressing

Smith & Nephew

NCT03146845

Phase Distribution

PhaseTrial count
Phase 2 1
Phase 4 3

Named interventions

Most-linked intervention names on Leg Ulcer records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Standard Care Device
1 trials
ALLEVYN Life Non-Bordered Device
1 trials
Cooling cotton pack Device
1 trials
Cooling gel pack Device
1 trials
Collagen ORC Antimicrobial Matrix (CAM) Device
1 trials
Sham laser treatment Other
1 trials
CO2RE® (Syneron Candela Corp, Wayland, MA) Device
1 trials
AM/Single - VLU Other
1 trials

US sites by state

Facility locations filed on Leg Ulcer trials. A trial with sites in several states counts in each.

Pennsylvania 3 trials
Texas 2 trials
Missouri 2 trials
Louisiana 2 trials
South Carolina 1 trials
Ohio 1 trials
Florida 1 trials
California 1 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Leg Ulcer page

9 registered trials, 5 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Leg Ulcer condition card totals 9 registered trials; most-linked intervention Standard Care; top US site state Pennsylvania. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.