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ClinicalTrials.gov 5 recruiting now official registry

Advanced Colorectal Cancer clinical trials

5 of 9 indexed Advanced Colorectal Cancer trials are currently recruiting.

9 US clinical trials · 5 currently recruiting

Advanced Colorectal Cancer is the subject of 9 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is AbbVie (prior sponsor, Abbott), running 1 of these trials.

The research picture

Advanced Colorectal Cancer has 9 registered US clinical trials, 5 of them open to new participants right now, about 56% of the total.

5
recruiting participants now
56%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
1
top sponsor: AbbVie (prior sponsor, Abbott)
Phase 14Phase 24Phase 31

Active & Recent Trials

9 total, page 1 of 1

RECRUITING Phase 1 514 participants

A First-in-human Study of BGB-53038, a Pan-KRAS Inhibitor, Alone or in Combinations in Participants With Advanced or Metastatic Solid Tumors With KRAS Mutations or Amplification

BeiGene

NCT06585488

RECRUITING Phase 2 150 participants

Evaluation of RBS2418 in Patients With Advanced, Metastatic, and Progressive Colorectal Cancer

Riboscience

NCT06824064

RECRUITING Phase 1 80 participants

A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of CBI-1214 T Cell Engager in Participants With Advanced or Metastatic MSS/MSI-L Colorectal Cancer

Cartography Biosciences

NCT07321106

RECRUITING Phase 2 33 participants

Open-label Phase 2 Study of Avutometinib (RAF/MEK Clamp) in Combination With Defactinib (FAK Inhibitor) and Cetuximab in Patients With Unresectable, Anti-EGFR-Refractory Advanced Colorectal Cancer

M.D. Anderson Cancer Center

NCT06369259

RECRUITING Phase 1 27 participants

Trial of ProAgio in Advanced/Metastatic Colorectal Cancer

University of Alabama at Birmingham

NCT06867822

ACTIVE NOT RECRUITING Phase 3 461 participants

Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)

Mirati Therapeutics

NCT04793958

COMPLETED Phase 2 159 participants

Phase 2 Study of ABT-869 in Combination With mFOLFOX6 Versus Bevacizumab in Combination With mFOLFOX6 to Treat Advanced Colorectal Cancer

AbbVie (prior sponsor, Abbott)

NCT00707889

COMPLETED Phase 1 23 participants

Effect of Curcumin on Dose Limiting Toxicity and Pharmacokinetics of Irinotecan in Patients With Solid Tumors

UNC Lineberger Comprehensive Cancer Center

NCT01859858

COMPLETED Phase 2 16 participants

Evaluate the Efficacy of MEDI4736 in Immunological Subsets of Advanced Colorectal Cancer

Memorial Sloan Kettering Cancer Center

NCT02227667

Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 4
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Advanced Colorectal Cancer Trial Landscape

9 indexed Advanced Colorectal Cancer studies · 5 recruiting (56%).

Phase mix: 1 late (III/IV) vs 8 early (I/II).

Top sponsor: AbbVie (prior sponsor, Abbott) (1 trial), 8 others listed. 9 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Advanced Colorectal Cancer?

PlainTrial tracks 9 US clinical trials for Advanced Colorectal Cancer, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Advanced Colorectal Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.