Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03644849 · ClinicalTrials.gov registry record · NA
Evaluating the Safety and Efficacy of Fractionated Carbon Dioxide Therapy in Postoperative Lower Extremity Wound Healing
A NA study of Leg Ulcer, sponsored by St. Louis University.
- Completed
- Registry status
- NA
- Development phase
- 48
- Enrollment target
- 2
- Study locations
NCT03644849: Completed NA study of Leg Ulcer, sponsored by St. Louis University.
NCT03644849 is a NA study of Leg Ulcer that has completed, run by St. Louis University. The registered enrollment target is 48 participants, below the 37,715-participant average among 8 other Leg Ulcer trials with a reported enrollment target (100% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03644849, a NA study of Leg Ulcer, has completed, sponsored by St. Louis University.
- COMPLETED
- Registry status
- NA
- Development phase
- 48 participants
- Enrollment target
- 2
- Study locations
Study Summary
This study will evaluate the efficacy and safety of laser therapy on postoperative lower extremity wound healing over 12 weeks. The investigators will include adult patients who have underwent Mohs Micrographic Surgery on their lower extremities. Patients with poor immune systems, current pregnancies, uncontrolled diabetes, lower extremity venous or arterial disease will not be included in this study. After surgery patients will be randomized into two groups. One group will receive a single laser treatment immediately after their surgery on their wound while the other will not. The group not receiving laser therapy will undergo a sham laser therapy treatment. Immediately after therapy and 4, 8, and 12 weeks postoperative patients will have a follow up visit. During these visits patients wound size will be recorded, a photograph will be taken, and the wound temperature will be measured. Patient will be given a diary to record any adverse events related to the wound.
Primary Outcome
Number of participants with completely healed lower extremity wounds by the end of the study (week 12). Complete wound healing is defined by reepithelization of the wound.
Conditions Studied
Interventions
- DEVICE CO2RE® (Syneron Candela Corp, Wayland, MA)
- OTHER Sham laser treatment
Study Locations (2)
Missouri
- Saint Louis University - St Louis
- Saint Louis University - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2018-09-28 |
| Est. Completion | 2020-11-19 |
| Phase | NA |
What the finished NCT03644849 record still lists
NCT03644849 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 48 participants, a relatively small participant target, below the 37,715-participant average among 8 other Leg Ulcer trials with a reported enrollment target (100% lower).
The record links to 1 condition, with Leg Ulcer appearing as the primary indexed condition, and to 2 interventions - of which CO2RE® (Syneron Candela Corp, Wayland, MA) is the first listed.
NCT03644849 reports a single indexed study location in Missouri.
Frequently Asked Questions
What is clinical trial NCT03644849 about?
NCT03644849 is a clinical study titled "Evaluating the Safety and Efficacy of Fractionated Carbon Dioxide Therapy in Postoperative Lower Extremity Wound Healing". This study will evaluate the efficacy and safety of laser therapy on postoperative lower extremity wound healing over 12 weeks. The investigators will include adult patients who have underwent Mohs Micrographic Surgery on their lower extremities. Patients with poor immune systems, current pregnancie...
What is the current status of trial NCT03644849?
This trial is currently completed. It is a NA study. The enrollment target is 48 participants. The study started on 2018-09-28. Estimated completion is 2020-11-19.
What conditions does trial NCT03644849 study?
This clinical trial studies the following conditions: Leg Ulcer.
What interventions are being tested in trial NCT03644849?
The interventions under investigation include: CO2RE® (Syneron Candela Corp, Wayland, MA) (DEVICE), Sham laser treatment (OTHER).
Who is sponsoring clinical trial NCT03644849?
This trial is sponsored by St. Louis University, which has 107 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03644849 being conducted?
This trial has 2 study locations across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Leg Ulcer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03644849's enrollment target sits among peer trials
48 7th of 8 higher than 1 of 8 other Leg Ulcer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Leg Ulcer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Modified Multi-Platform Trial Assessing Multiple CAMPs and SOC vs SOC Alone in the Treatment of DFU and VLUs
RECRUITING · NA
-
Clinical Trial Assessing Human Placental Membrane Products and Standard of Care Versus Standard of Care in Nonhealing DFUs and VLUs
RECRUITING · NA
-
Evaluation Of An Advanced Borderless Dressing
COMPLETED · NA
-
A Real-World Registry of Chronic Wounds and Ulcers
RECRUITING
-
Trial Assessing the Efficacy of Human Placental Membrane Products and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers
RECRUITING · Phase 4
-
Evaluating Several Cellular, Acellular, and Matrix-like Products (CAMPs) and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot and Venous Leg Ulcers.
RECRUITING · Phase 4
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01765777 · 48 participants · NA
Efficacy of Osteopathic Manipulative Medicine (OMM) and Phototherapy for Patients With Chronic Lower Back Pain
- NCT03073343 · 48 participants · NA
A Prospective, Randomized, Open Label Trial of Two Doses of Oral Betaine
- NCT03431064 · 48 participants
Lung Recruitment Maneuver as a Potential Predictor of Fluid Responsiveness in Mechanically Ventilated Pediatric Patients
- NCT03514602 · 48 participants · NA
Maternal Smoking Cessation and Pediatric Obesity Prevention
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI