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ClinicalTrials.gov 5 recruiting now official registry

Juvenile Myelomonocytic Leukemia clinical trials

5 of 12 indexed Juvenile Myelomonocytic Leukemia trials are currently recruiting.

12 US clinical trials · 5 currently recruiting

Juvenile Myelomonocytic Leukemia is the subject of 12 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is Children's Oncology Group, running 4 of these trials.

The research picture

Juvenile Myelomonocytic Leukemia has 12 registered US clinical trials, 5 of them open to new participants right now, about 42% of the total.

5
recruiting participants now
42%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
4
top sponsor: Children's Oncology Group
Phase 15Phase 24Phase 32

Active & Recent Trials

12 total, page 1 of 1

RECRUITING Phase 1 960 participants

The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study

PedAL BCU

NCT04726241

RECRUITING Phase 1 50 participants

A Phase 1 Trial of CIML NK Cell Infusion for Myeloid Disease Relapse After Hematopoietic Cell Transplantation

Dana-Farber Cancer Institute

NCT04024761

RECRUITING NA 50 participants

CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post TCRαβ/CD19 Depleted HSCT

Children's Hospital of Philadelphia

NCT03810196

RECRUITING Phase 1 24 participants

HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant

Fred Hutchinson Cancer Center

NCT03326921

RECRUITING Phase 2 20 participants

Alpha/Beta T Cell and CD19+ B Cell Depletion in Allogeneic Stem Cell Transplantation in Patients With Malignant Diseases

University of Florida

NCT05800210

ACTIVE NOT RECRUITING Phase 1 15 participants

Vorinostat Dose-escalation After Allogeneic Hematopoietic Cell Transplantation

Johns Hopkins All Children's Hospital

NCT03843528

ACTIVE NOT RECRUITING Phase 2 10 participants

Trametinib in Treating Patients With Relapsed or Refractory Juvenile Myelomonocytic Leukemia

National Cancer Institute (NCI)

NCT03190915

COMPLETED Phase 3 226 participants

Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant

Children's Oncology Group

NCT01305200

COMPLETED Phase 1 70 participants

Sorafenib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Leukemia

National Cancer Institute (NCI)

NCT01445080

COMPLETED Phase 2 39 participants

Etanercept in Treating Young Patients With Idiopathic Pneumonia Syndrome After Undergoing a Donor Stem Cell Transplant

Children's Oncology Group

NCT00309907

COMPLETED Phase 2 30 participants

Busulfan, Cyclophosphamide, and Melphalan or Busulfan and Fludarabine Phosphate Before Donor Hematopoietic Cell Transplant in Treating Younger Patients With Juvenile Myelomonocytic Leukemia

Children's Oncology Group

NCT01824693

COMPLETED Phase 3 27 participants

Donor Bone Marrow Transplant With or Without G-CSF in Treating Young Patients With Hematologic Cancer or Other Diseases

Children's Oncology Group

NCT00450450

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 4
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Juvenile Myelomonocytic Leukemia Trial Landscape

12 indexed Juvenile Myelomonocytic Leukemia studies · 5 recruiting (42%).

Phase mix: 2 late (III/IV) vs 9 early (I/II).

Top sponsor: Children's Oncology Group (4 trials), 7 others listed. 12 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Juvenile Myelomonocytic Leukemia?

PlainTrial tracks 12 US clinical trials for Juvenile Myelomonocytic Leukemia, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Juvenile Myelomonocytic Leukemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.