Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 5 recruiting now official registry

Immunoglobulin A Nephropathy clinical trials

Every US clinical trial registered for Immunoglobulin A Nephropathy — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

14 US clinical trials · 5 currently recruiting

The research picture

Immunoglobulin A Nephropathy has 14 registered US clinical trials, 5 of them open to new participants right now — about 36% of the total.

5
recruiting participants now
36%
of trials open to enrollment
7
in Phase 3–4 (later-stage)
4
top sponsor: Travere Therapeutics

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING Phase 3 510 participants

Study of Ravulizumab in Immunoglobulin A Nephropathy (IgAN)

Alexion Pharmaceuticals

NCT06291376

RECRUITING 300 participants

A Mobile App-Based Study to Evaluate Disease Burden and Treatment Patterns in Immunoglobulin A Nephropathy (IgAN) in the US

Novartis Pharmaceuticals

NCT06952426

RECRUITING Phase 2 67 participants

Study of Sparsentan Treatment in Pediatrics With Proteinuric Glomerular Diseases

Travere Therapeutics

NCT05003986

RECRUITING Phase 3 24 participants

Study of Ravulizumab in Pediatric Participants With Primary IgAN

Alexion Pharmaceuticals

NCT07024563

RECRUITING Phase 2 20 participants

Study to Evaluate the Impact of Iptacopan on Top of SOC on Biopsy Changes in Kidneys of Adult Patients With IgAN

Novartis Pharmaceuticals

NCT06797518

ACTIVE NOT RECRUITING Phase 3 605 participants

Evaluation of Efficacy of Povetacicept in Adults With Immunoglobulin A Nephropathy (IgAN)

Alpine Immune Sciences Inc, A Subsidiary of Vertex

NCT06564142

ACTIVE NOT RECRUITING Phase 3 530 participants

Trial of Sibeprenlimab in the Treatment of A Nephropathy (IgAN)

Otsuka Pharmaceutical Development & Commercialization

NCT05248646

ACTIVE NOT RECRUITING Phase 3 406 participants

A Study of the Effect and Safety of Sparsentan in the Treatment of Patients With IgA Nephropathy

Travere Therapeutics

NCT03762850

ACTIVE NOT RECRUITING Phase 3 404 participants

Atrasentan in Patients With IgA Nephropathy

Chinook Therapeutics

NCT04573478

ACTIVE NOT RECRUITING Phase 3 383 participants

A Study of Zigakibart in Adults With IgA Nephropathy

Novartis Pharmaceuticals

NCT05852938

ACTIVE NOT RECRUITING Phase 2 103 participants

Atrasentan in Patients With Proteinuric Glomerular Diseases

Novartis Pharmaceuticals

NCT04573920

ACTIVE NOT RECRUITING Phase 1 72 participants

An Open-label Study of Povetacicept in Autoantibody-Associated Glomerular Diseases

Alpine Immune Sciences

NCT05732402

COMPLETED 487 participants

Humanistic Burden of (FSGS) Focal Segmental Glomerulosclerosis and IgAN (Immunoglobulin A Nephropathy)

Travere Therapeutics

NCT05200871

COMPLETED Phase 2 48 participants

A Study to Investigate Safety and Effect of Sparsentan in Combination With SGLT2 Inhibition in Participants With IgAN

Travere Therapeutics

NCT05856760

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 4
Phase 3 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Immunoglobulin A Nephropathy Trial Landscape

ClinicalTrials.gov lists 14 US studies indexed under Immunoglobulin A Nephropathy, and 5 of those are currently open to recruitment — roughly 36% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Immunoglobulin A Nephropathy shows 7 late-stage studies (Phase 3 and Phase 4 combined) alongside 5 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Immunoglobulin A Nephropathy is led by Travere Therapeutics with 4 indexed trials, alongside 6 other organizations in the top contributor list. The list on this page surfaces up to 14 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Immunoglobulin A Nephropathy?

PlainTrial tracks 14 US clinical trials for Immunoglobulin A Nephropathy, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Immunoglobulin A Nephropathy?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →