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COMPLETED Phase 2

A Study to Investigate Safety and Effect of Sparsentan in Combination With SGLT2 Inhibition in Participants With IgAN

NCT05856760 · View on ClinicalTrials.gov ↗

Study Summary

This was a 28-week, open-label, multicenter, single-group Phase 2 exploratory study to determine the safety and effect of sparsentan in participants with IgAN who are at risk of disease progression to kidney failure despite being on both stable RAASi and SGLT2 inhibitor treatment for at least 12 weeks prior to study entry

Interventions

  • DRUG Sparsentan

Study Locations (20)

California

  • Travere Investigational Site — Chula Vista
  • Travere Investigational Site — Garden Grove
  • Travere Investigational Site — Glendale

Idaho

  • Travere Investigational Site — Boise
  • Travere Investigational Site — Chubbuck
  • Travere Investigational Site — Idaho Falls

New York

  • Travere Investigation Site — Clifton Park
  • Travere Investigational Site — Fresh Meadows
  • Travere Investigational Site — New York

Illinois

  • Travere Investigational Site — Chicago
  • Travere Investigational Site — Evergreen Park

North Carolina

  • Travere Investigational Site — Jacksonville
  • Travere Investigational Site — New Bern

Alabama

  • Travere Investigational Site — Birmingham

Colorado

  • Travere Investigational Site — Denver

Indiana

  • Travere Investigational Site — Fort Wayne

Trial Details

FieldValue
Enrollment Target 48 participants
Start Date 2023-05-19
Est. Completion 2024-10-25
Phase Phase 2

Sponsor

Travere Therapeutics

9 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05856760

The ClinicalTrials.gov registry entry for NCT05856760 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 48 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Travere Therapeutics, which has 9 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Immunoglobulin A Nephropathy appearing as the primary indexed condition, and to 1 intervention — of which Sparsentan is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05856760 reports 20 study locations spanning 12 distinct geographic areas — top geographies include California, Idaho, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05856760 about?

NCT05856760 is a clinical study titled "A Study to Investigate Safety and Effect of Sparsentan in Combination With SGLT2 Inhibition in Participants With IgAN". This was a 28-week, open-label, multicenter, single-group Phase 2 exploratory study to determine the safety and effect of sparsentan in participants with IgAN who are at risk of disease progression to kidney failure despite being on both stable RAASi and SGLT2 inhibitor treatment for at least 12 wee...

What is the current status of trial NCT05856760?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 48 participants. The study started on 2023-05-19. Estimated completion is 2024-10-25.

What conditions does trial NCT05856760 study?

This clinical trial studies the following conditions: Immunoglobulin A Nephropathy. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05856760?

The interventions under investigation include: Sparsentan (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05856760?

This trial is sponsored by Travere Therapeutics, which has 9 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05856760 being conducted?

This trial has 20 study locations across Alabama, California, Colorado, Idaho, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial