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ClinicalTrials.gov 5 recruiting now official registry

Migraine Disorders clinical trials

Every US clinical trial registered for Migraine Disorders — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

22 US clinical trials · 5 currently recruiting

The research picture

Migraine Disorders has 22 registered US clinical trials, 5 of them open to new participants right now — about 23% of the total.

5
recruiting participants now
23%
of trials open to enrollment
9
in Phase 3–4 (later-stage)
6
top sponsor: GlaxoSmithKline

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING NA 400 participants

Responding With Evidence and Access for Childhood Headaches

Children's Hospital Medical Center, Cincinnati

NCT05889624

RECRUITING NA 260 participants

Mind Body Balance for Pediatric Migraine

Children's Hospital Medical Center, Cincinnati

NCT04715685

RECRUITING Phase 2 160 participants

Migraine Manager (R01)

Children's Hospital Medical Center, Cincinnati

NCT04567355

RECRUITING Phase 4 132 participants

Qudexy XR for the Prevention of Migraine in Children 6 to 11 Years Old

Upsher-Smith Laboratories

NCT04748601

RECRUITING NA 60 participants

Determining the Utility of a Behavioral Intervention in Chronic Migraine

Mayo Clinic

NCT05415020

ACTIVE NOT RECRUITING NA 224 participants

Intervention for Sleep and Pain in Youth: a Randomized Controlled Trial

Seattle Children's Hospital

NCT04936321

ACTIVE NOT RECRUITING 10 participants

An Open Label, Study of DaxibotulinumtoxinA for Migraine Prevention

Ki Health Partners.

NCT06154070

COMPLETED Phase 3 902 participants

Phase 3 Study of MAP0004 in Adult Migraineurs

Allergan

NCT00623636

COMPLETED Phase 3 898 participants

A Multicenter Assessment of ALD403 in Frequent Episodic Migraine

Alder Biopharmaceuticals

NCT02559895

COMPLETED Phase 3 656 participants

Long-Term Safety of Treximet (Sumatriptan/Naproxen Sodium) for Migraine in Adolescents

GlaxoSmithKline

NCT00488514

COMPLETED Phase 3 623 participants

Study Of Treximet, Formerly Known as Trexima, In The Acute Treatment Of Multiple Migraine Attacks

GlaxoSmithKline

NCT00240617

COMPLETED Phase 2 526 participants

Prevention Study in Adult Patients Suffering From Migraine Headaches

XenoPort

NCT00742209

COMPLETED Phase 4 407 participants

A Study to Determine the Effect of Sumatriptan and Naproxen Sodium Combination Tablet, Sumatriptan Tablet, and Naproxen Sodium Tablet on Blood Pressure When Treating Migraine Headaches That Occur During a 6-month Period

GlaxoSmithKline

NCT00792636

COMPLETED Phase 3 375 participants

TREXIMET® Versus Butalbital-containing Combination Medications for the Acute Treatment of Migraine in Adults

GlaxoSmithKline

NCT00573170

COMPLETED Phase 3 320 participants

Treximet (Sumatriptan/Naproxen Sodium), Formerly Known as TREXIMA, for Menstrual Migraine in Women With Dysmenorrhea

GlaxoSmithKline

NCT00329459

COMPLETED Phase 4 282 participants

Efficacy and Safety Study of BOTOX® Compared to Topiramate for the Prevention of Chronic Migraine in Adults

Allergan

NCT02191579

COMPLETED NA 231 participants

Non-invasive Vagus Nerve Stimulation for the Prevention of Migraines

ElectroCore

NCT03716505

COMPLETED NA 61 participants

Integrative Migraine Pain Alleviation Through Chiropractic Therapy

Harvard University Faculty of Medicine

NCT03177616

COMPLETED Phase 1 50 participants

A Pharmacokinetic Study to Evaluate TREXIMET in Adolescents With Migraine and Healthy Subjects Administered at Three Doses.

GlaxoSmithKline

NCT00989625

COMPLETED NA 22 participants

A Study of Home-Delivered Neurostimulation for Migraine

MJHS Institute for Innovation in Palliative Care

NCT03874351

COMPLETED Phase 1 19 participants

Sofusa System With Sumatriptan (KC5010) Phase 1 Dose Escalation Safety and PK Study (KCC-SMT-002)

Sorrento Therapeutics

NCT03229798

COMPLETED 1 participants

Stroke-like Migraine Attacks After Radiation Treatment (SMART) Syndrome Language Intervention

Quality Living

NCT03662295

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 2
Phase 3 6
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Migraine Disorders Trial Landscape

ClinicalTrials.gov lists 22 US studies indexed under Migraine Disorders, and 5 of those are currently open to recruitment — roughly 23% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Migraine Disorders shows 9 late-stage studies (Phase 3 and Phase 4 combined) alongside 4 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Migraine Disorders is led by GlaxoSmithKline with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 22 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Migraine Disorders?

PlainTrial tracks 22 US clinical trials for Migraine Disorders, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Migraine Disorders?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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