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HIV Pre-exposure Prophylaxis: full-pipeline trial registry
4 of 9 indexed HIV Pre-exposure Prophylaxis trials are currently recruiting.
Corpus placement: #1,916 of 28,707 conditions by registered trial count.
9 US clinical trials · 4 currently recruiting · #1,916 of 28,707 conditions by registered trial count
HIV Pre-exposure Prophylaxis: 9 US clinical trials tracked, 4 recruiting.
HIV Pre-exposure Prophylaxis is the subject of 9 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 3 in Phase 1-2 (earlier-stage). The most active sponsor is Merck Sharp & Dohme, running 4 of these trials.
Enrollment posture brief
Registry condition hiv-pre-exposure-prophylaxis
OPEN 4 | RECR 44% | LATE 3 | EARLY 3 | RANK #1916 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Acute Ischemic Stroke (44% recruiting · 27 trials)
HIV Pre-exposure Prophylaxis lists 4 open slots (44% of 9 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for HIV Pre-exposure Prophylaxis on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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HIV Pre-exposure Prophylaxis is recruiting below its size-band peers.
4 of 9 indexed trials (44.4%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates HIV Pre-exposure Prophylaxis research.
Merck Sharp & Dohme accounts for 4 of 9 trials (44.4%). 6 distinct sponsors appear on at least one study for this condition label.
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Typical HIV Pre-exposure Prophylaxis enrolment sits around 350 participants.
Median target enrolment is 350 among the 9 trials that report a genuine target (sentinel values excluded). 2 of those (22.2%) plan for fewer than 100 participants.
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HIV Pre-exposure Prophylaxis research is mostly interventional.
8 interventional and 1 observational studies make up this index (88.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
9 total, page 1 of 1
A Clinical Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-011)
Merck Sharp & Dohme
NCT07044297
Client-Centered Care Coordination for Black Men Who Have Sex With Men
University of Maryland, Baltimore
NCT06056544
Study of Lenacapavir as a Once-Yearly Injection for HIV Pre-exposure Prophylaxis (PrEP)
Gilead Sciences
NCT07047716
Enhancing PrEP Uptake and Retention Among Latine TGW and GBM in the South Using Long-Acting Injectable PrEP
Duke University
NCT07218211
Evaluating the Effectiveness of a Mobile HIV Prevention App to Increase HIV and Sexually Transmitted Infections (STI) Testing and PrEP Initiation Among Rural Men Who Have Sex With Men
Emory University
NCT06205368
A Study of MK-8527 in Healthy Lactating Female Participants (MK-8527-009)
Merck Sharp & Dohme
NCT06580587
Sustainable Healthcenter Implementation PrEP Pilot Study
Centers for Disease Control and Prevention
NCT02074891
Safety and Pharmacokinetic Study of Oral MK-8527 QM in Participants at Low-Risk for HIV-1 Infection (MK-8527-007)
Merck Sharp & Dohme
NCT06045507
A Drug-Drug Interaction Study of MK 8527 With a Combined Oral Contraceptive (LNG/EE)
Merck Sharp & Dohme
NCT06783192
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 1 |
| Phase 3 | 2 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on HIV Pre-exposure Prophylaxis records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on HIV Pre-exposure Prophylaxis trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this HIV Pre-exposure Prophylaxis page
9 registered trials, 4 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 4 HIV Pre-exposure Prophylaxis trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Merck Sharp & Dohme sponsors the most HIV Pre-exposure Prophylaxis trials on record, review their full trial history before evaluating a specific study. See Merck Sharp & Dohme's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This HIV Pre-exposure Prophylaxis condition card totals 9 registered trials; most-linked intervention MK-8527; top US site state Pennsylvania. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.