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Hepatic Encephalopathy clinical trials
Every US clinical trial registered for Hepatic Encephalopathy — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
13 US clinical trials · 5 currently recruiting
The research picture
Hepatic Encephalopathy has 13 registered US clinical trials, 5 of them open to new participants right now — about 38% of the total.
- 5
- recruiting participants now
- 38%
- of trials open to enrollment
- 4
- in Phase 3–4 (later-stage)
- 4
- top sponsor: Bausch Health Americas
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
TReatment for ImmUne Mediated PathopHysiology
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT04862221
Late Evening and Early Morning Protein Supplement to Reduce Readmissions for Hepatic Encephalopathy
The Cleveland Clinic
NCT04096014
Hepatic Encephalopathy and Albumin Lasting Cognitive Improvement
Hunter Holmes Mcguire Veteran Affairs Medical Center
NCT06052176
Affect of Melatonin on Sleep and Cognition in Cirrhosis
Weill Medical College of Cornell University
NCT07046429
Pilot Open-Label Trial of Resistant Potato Starch in Patients With Cirrhosis and Overt Hepatic Encephalopathy
Mayo Clinic
NCT06425380
Study to Assess Rifaximin Soluble Solid Dispersion (SSD) for the Delay of Encephalopathy Decompensation in Cirrhosis
Bausch Health Americas
NCT05071716
Evaluation of Rifaximin SSD for Delaying Encephalopathy Decompensation in Patients With Cirrhosis
Bausch Health Americas
NCT05297448
Fecal Microbiota Transplant as Treatment of Hepatic Encephalopathy
Massachusetts General Hospital
NCT03420482
Safety and Tolerability Study of Rifaximin in Participants With a History of Hepatic Encephalopathy
Bausch Health Americas
NCT00686920
The Safety/Efficacy of Rifaximin With/Without Lactulose in Participants With A History of Recurrent Hepatic Encephalopathy
Bausch Health Americas
NCT01842581
A Study of Safety and Efficacy of HPN-100 in Subjects With Cirrhosis and Episodic Hepatic Encephalopathy
Amgen
NCT00999167
FMT in Cirrhosis and Hepatic Encephalopathy
VA Office of Research and Development
NCT03796598
Rifaximin in Minimal Hepatic Encephalopathy
Hunter Holmes Mcguire Veteran Affairs Medical Center
NCT00533910
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 4 |
| Phase 3 | 3 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Hepatic Encephalopathy Trial Landscape
ClinicalTrials.gov lists 13 US studies indexed under Hepatic Encephalopathy, and 5 of those are currently open to recruitment — roughly 38% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Hepatic Encephalopathy shows 4 late-stage studies (Phase 3 and Phase 4 combined) alongside 5 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Hepatic Encephalopathy is led by Bausch Health Americas with 4 indexed trials, alongside 8 other organizations in the top contributor list. The list on this page surfaces up to 13 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Hepatic Encephalopathy?
PlainTrial tracks 13 US clinical trials for Hepatic Encephalopathy, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Hepatic Encephalopathy?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.