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ClinicalTrials.gov 5 recruiting now official registry

Hepatic Encephalopathy clinical trials

Every US clinical trial registered for Hepatic Encephalopathy — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

13 US clinical trials · 5 currently recruiting

The research picture

Hepatic Encephalopathy has 13 registered US clinical trials, 5 of them open to new participants right now — about 38% of the total.

5
recruiting participants now
38%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
4
top sponsor: Bausch Health Americas

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING Phase 2 163 participants

TReatment for ImmUne Mediated PathopHysiology

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT04862221

RECRUITING NA 40 participants

Late Evening and Early Morning Protein Supplement to Reduce Readmissions for Hepatic Encephalopathy

The Cleveland Clinic

NCT04096014

RECRUITING Phase 2 30 participants

Hepatic Encephalopathy and Albumin Lasting Cognitive Improvement

Hunter Holmes Mcguire Veteran Affairs Medical Center

NCT06052176

RECRUITING NA 18 participants

Affect of Melatonin on Sleep and Cognition in Cirrhosis

Weill Medical College of Cornell University

NCT07046429

RECRUITING NA 11 participants

Pilot Open-Label Trial of Resistant Potato Starch in Patients With Cirrhosis and Overt Hepatic Encephalopathy

Mayo Clinic

NCT06425380

ACTIVE NOT RECRUITING Phase 3 524 participants

Study to Assess Rifaximin Soluble Solid Dispersion (SSD) for the Delay of Encephalopathy Decompensation in Cirrhosis

Bausch Health Americas

NCT05071716

ACTIVE NOT RECRUITING Phase 3 466 participants

Evaluation of Rifaximin SSD for Delaying Encephalopathy Decompensation in Patients With Cirrhosis

Bausch Health Americas

NCT05297448

ACTIVE NOT RECRUITING Phase 2 30 participants

Fecal Microbiota Transplant as Treatment of Hepatic Encephalopathy

Massachusetts General Hospital

NCT03420482

COMPLETED Phase 3 322 participants

Safety and Tolerability Study of Rifaximin in Participants With a History of Hepatic Encephalopathy

Bausch Health Americas

NCT00686920

COMPLETED Phase 4 222 participants

The Safety/Efficacy of Rifaximin With/Without Lactulose in Participants With A History of Recurrent Hepatic Encephalopathy

Bausch Health Americas

NCT01842581

COMPLETED Phase 2 189 participants

A Study of Safety and Efficacy of HPN-100 in Subjects With Cirrhosis and Episodic Hepatic Encephalopathy

Amgen

NCT00999167

COMPLETED Phase 1 60 participants

FMT in Cirrhosis and Hepatic Encephalopathy

VA Office of Research and Development

NCT03796598

COMPLETED NA 42 participants

Rifaximin in Minimal Hepatic Encephalopathy

Hunter Holmes Mcguire Veteran Affairs Medical Center

NCT00533910

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 4
Phase 3 3
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Hepatic Encephalopathy Trial Landscape

ClinicalTrials.gov lists 13 US studies indexed under Hepatic Encephalopathy, and 5 of those are currently open to recruitment — roughly 38% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Hepatic Encephalopathy shows 4 late-stage studies (Phase 3 and Phase 4 combined) alongside 5 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Hepatic Encephalopathy is led by Bausch Health Americas with 4 indexed trials, alongside 8 other organizations in the top contributor list. The list on this page surfaces up to 13 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Hepatic Encephalopathy?

PlainTrial tracks 13 US clinical trials for Hepatic Encephalopathy, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Hepatic Encephalopathy?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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