Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
HCC: early-phase trial registry
9 of 14 indexed HCC trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #1,230 of 28,707 conditions by registered trial count.
14 US clinical trials · 9 currently recruiting · #1,230 of 28,707 conditions by registered trial count
HCC: 14 US clinical trials tracked, 9 recruiting.
HCC is the subject of 14 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is Geneos Therapeutics, running 1 of these trials.
Enrollment posture brief
Registry condition hcc
OPEN 9 | RECR 64% | LATE 1 | EARLY 8 | RANK #1230 | SPON 1
Volume-matched condition peers
Nearest open-share peer: Cardiac Rehabilitation (64% recruiting · 14 trials)
HCC lists 9 open slots (64% of 14 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for HCC on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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HCC is recruiting above its size-band peers.
9 of 14 indexed trials (64.3%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of HCC trials is spread across many organizations.
Geneos Therapeutics accounts for 1 of 14 trials (7.1%). 14 distinct sponsors appear on at least one study for this condition label.
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Most HCC trials plan to enrol fewer than 100 people.
Median target enrolment is 70 among the 14 trials that report a genuine target (sentinel values excluded). 9 of those (64.3%) plan for fewer than 100 participants.
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HCC research is mostly interventional.
12 interventional and 2 observational studies make up this index (85.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
14 total, page 1 of 1
Multi-analyte Blood Test Clinical Trial
Helio Genomics
NCT05199259
CEUS vs. AMRI for HCC Detection in Patients With Indeterminate Liver Nodules
University of Texas Southwestern Medical Center
NCT06184152
HOPE Against Cancer Recurrence in HCC
Philipp Dutkowski
NCT06717919
Optimizing Y90 Therapy for Radiation Lobectomy
Northwestern University
NCT04390724
Study of the Theranostic Pair RYZ811 (Diagnostic) and RYZ801 (Therapeutic) to Identify and Treat Subjects With GPC3+ Unresectable HCC
RayzeBio
NCT06726161
REGULUS: MRI-guided Adaptive SABR for Liver Cancers
Stanford University
NCT07223307
Effect of the HCC Liver-Link Intervention
Indiana University
NCT06728293
Cabozantinib Combined With Ipilimumab/Nivolumab and TACE in Patients With Hepatocellular Carcinoma
University of California, Irvine
NCT04472767
Y-90 Treatment Response Using Transarterial Radioembolization
Thomas Jefferson University
NCT07145801
GNOS-PV02 Personalized Neoantigen Vaccine, INO-9012 and Pembrolizumab in Subjects with Advanced HCC
Geneos Therapeutics
NCT04251117
Study of Mogamulizumab + Nivolumab in Subjects w/Locally Advanced or Metastatic Solid Tumors
Kyowa Kirin
NCT02705105
Evaluation of Liver Cancer With Magnetic Resonance Imaging (MRI)
Icahn School of Medicine at Mount Sinai
NCT01871545
A Clinical Research Study to Determine Whether PD 0332991 May Be Effective in Treating Patients With Liver Cancer
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
NCT01356628
Integrated Imaging Strategy to Phenotype Progression of Liver Tumors During and After Chemoembolization
National Institutes of Health Clinical Center (CC)
NCT02471313
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 5 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on HCC records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on HCC trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this HCC page
14 registered trials, 9 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 9 HCC trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Geneos Therapeutics sponsors the most HCC trials on record, review their full trial history before evaluating a specific study. See Geneos Therapeutics's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This HCC condition card totals 14 registered trials; most-linked intervention PD-0332991; top US site state Maryland. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.