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ClinicalTrials.gov 9 recruiting now official registry

HCC clinical trials

9 of 14 indexed HCC trials are currently recruiting.

14 US clinical trials · 9 currently recruiting

HCC is the subject of 14 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is Geneos Therapeutics, running 1 of these trials.

The research picture

HCC has 14 registered US clinical trials, 9 of them open to new participants right now, about 64% of the total.

9
recruiting participants now
64%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
1
top sponsor: Geneos Therapeutics
Phase 13Phase 25Phase 41

Active & Recent Trials

14 total, page 1 of 1

RECRUITING 1,200 participants

Multi-analyte Blood Test Clinical Trial

Helio Genomics

NCT05199259

RECRUITING NA 600 participants

CEUS vs. AMRI for HCC Detection in Patients With Indeterminate Liver Nodules

University of Texas Southwestern Medical Center

NCT06184152

RECRUITING Phase 4 220 participants

HOPE Against Cancer Recurrence in HCC

Philipp Dutkowski

NCT06717919

RECRUITING 104 participants

Optimizing Y90 Therapy for Radiation Lobectomy

Northwestern University

NCT04390724

RECRUITING Phase 1 70 participants

Study of the Theranostic Pair RYZ811 (Diagnostic) and RYZ801 (Therapeutic) to Identify and Treat Subjects With GPC3+ Unresectable HCC

RayzeBio

NCT06726161

RECRUITING Phase 2 62 participants

REGULUS: MRI-guided Adaptive SABR for Liver Cancers

Stanford University

NCT07223307

RECRUITING NA 40 participants

Effect of the HCC Liver-Link Intervention

Indiana University

NCT06728293

RECRUITING Phase 2 35 participants

Cabozantinib Combined With Ipilimumab/Nivolumab and TACE in Patients With Hepatocellular Carcinoma

University of California, Irvine

NCT04472767

RECRUITING Phase 2 30 participants

Y-90 Treatment Response Using Transarterial Radioembolization

Thomas Jefferson University

NCT07145801

ACTIVE NOT RECRUITING Phase 1 36 participants

GNOS-PV02 Personalized Neoantigen Vaccine, INO-9012 and Pembrolizumab in Subjects with Advanced HCC

Geneos Therapeutics

NCT04251117

COMPLETED Phase 1 114 participants

Study of Mogamulizumab + Nivolumab in Subjects w/Locally Advanced or Metastatic Solid Tumors

Kyowa Kirin

NCT02705105

COMPLETED NA 84 participants

Evaluation of Liver Cancer With Magnetic Resonance Imaging (MRI)

Icahn School of Medicine at Mount Sinai

NCT01871545

COMPLETED Phase 2 23 participants

A Clinical Research Study to Determine Whether PD 0332991 May Be Effective in Treating Patients With Liver Cancer

Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

NCT01356628

COMPLETED Phase 2 3 participants

Integrated Imaging Strategy to Phenotype Progression of Liver Tumors During and After Chemoembolization

National Institutes of Health Clinical Center (CC)

NCT02471313

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 5
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the HCC Trial Landscape

14 indexed HCC studies · 9 recruiting (64%).

Phase mix: 1 late (III/IV) vs 8 early (I/II).

Top sponsor: Geneos Therapeutics (1 trial), 9 others listed. 14 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for HCC?

PlainTrial tracks 14 US clinical trials for HCC, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for HCC?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.