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ClinicalTrials.gov 11 recruiting now official registry

Gastroesophageal-junction Cancer clinical trials

11 of 20 indexed Gastroesophageal-junction Cancer trials are currently recruiting.

20 US clinical trials · 11 currently recruiting

Gastroesophageal-junction Cancer is the subject of 20 registered US clinical trials on ClinicalTrials.gov, 11 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is AstraZeneca, running 4 of these trials.

The research picture

Gastroesophageal-junction Cancer has 20 registered US clinical trials, 11 of them open to new participants right now, about 55% of the total.

11
recruiting participants now
55%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
4
top sponsor: AstraZeneca
Phase 112Phase 23Phase 33

Active & Recent Trials

20 total, page 1 of 1

RECRUITING Phase 3 726 participants

Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer

Daiichi Sankyo

NCT06731478

RECRUITING Phase 3 572 participants

AZD0901 Compared With Investigator's Choice of Therapy in Participants With Second- or Later-line Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Expressing Claudin18.2

AstraZeneca

NCT06346392

RECRUITING Phase 3 550 participants

A Phase Ⅲ Clinical Study of HLX22 in Combination With Trastuzumab and Chemotherapy for the Treatment of Gastroesophageal Junction and Gastric Cancer

Shanghai Henlius Biotech

NCT06532006

RECRUITING Phase 1 523 participants

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

Merus B.V.

NCT03526835

RECRUITING NA 300 participants

Locally ablatIVe thErapy for oLigo-progressive gastrOintestiNal maliGnancies (LIVELONG)

University of California, Davis

NCT06101277

RECRUITING Phase 1 280 participants

Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

SystImmune

NCT06293898

RECRUITING Phase 2 224 participants

AZD0901 in Participants With Advanced Solid Tumours Expressing Claudin18.2

AstraZeneca

NCT06219941

RECRUITING Phase 1 165 participants

IKS014 in Advanced Solid Tumors That Express HER2

Iksuda Therapeutics

NCT05872295

RECRUITING Phase 1 117 participants

Study for AZD4360 in Participants With Advanced Solid Tumours

AstraZeneca

NCT06921928

RECRUITING 50 participants

Registry for Esophageal and Gastroesophageal Junction Cancer

Memorial Sloan Kettering Cancer Center

NCT06558786

RECRUITING Phase 1 42 participants

CA-4948 in Combination With FOLFOX/PD-1 Inhibitor +/- Trastuzumab for Untreated Unresectable Gastric and Esophageal Cancer

Washington University School of Medicine

NCT05187182

ACTIVE NOT RECRUITING Phase 1 150 participants

A Trial to Evaluate Safety and Tolerability of TST001 in Advanced or Metastatic Solid Tumors

Suzhou Transcenta Therapeutics Co.

NCT04396821

ACTIVE NOT RECRUITING Phase 1 136 participants

A Study to Assess the Safety and Efficacy of AZD7789 in Participants With Advanced or Metastatic Solid Cancer

AstraZeneca

NCT04931654

ACTIVE NOT RECRUITING Phase 1 120 participants

Evaluate BL-M17D1 in Patients w/HER2-Expressing/Mutant Advanced or Metastatic Solid Tumors

SystImmune

NCT06714617

ACTIVE NOT RECRUITING Phase 1 72 participants

A Study Evaluating Bemarituzumab in Combination With Other Anti-cancer Therapies in Subjects With Previously Untreated Advanced Gastric or Gastroesophageal Junction Cancer.

Amgen

NCT05322577

ACTIVE NOT RECRUITING Phase 1 56 participants

Claudin 18.2-Targeted Chimeric Antigen Receptor T-cells in Subjects With Unresectable, Locally Advanced, or Metastatic Gastric, Gastroesophageal Junction (GEJ), Esophageal, or Pancreatic Adenocarcinoma

Legend Biotech USA

NCT05539430

ACTIVE NOT RECRUITING Phase 2 1 participants

Adjuvant Trastuzumab Deruxtecan (Enhertu) & Nivolumab For Patients Who Are Disease Free After Completion of Trimodality Treatment For HER-2+ Cancers of Esophagus & Gastroesophageal Junction

Brown University

NCT05480384

COMPLETED Phase 1 120 participants

Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid Tumors

Novartis Pharmaceuticals

NCT01576666

COMPLETED Phase 1 40 participants

A Safety and Tolerability Study of INCAGN02390 in Select Advanced Malignancies

Incyte Corporation

NCT03652077

COMPLETED Phase 2 35 participants

Sorafenib for Patients With Metastatic or Recurrent Esophageal and Gastroesophageal Junction Cancer

Memorial Sloan Kettering Cancer Center

NCT00917462

Phase Distribution

PhaseTrial count
Phase 1 12
Phase 2 3
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Gastroesophageal-junction Cancer Trial Landscape

20 indexed Gastroesophageal-junction Cancer studies · 11 recruiting (55%).

Phase mix: 3 late (III/IV) vs 15 early (I/II).

Top sponsor: AstraZeneca (4 trials), 9 others listed. 20 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Gastroesophageal-junction Cancer?

PlainTrial tracks 20 US clinical trials for Gastroesophageal-junction Cancer, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Gastroesophageal-junction Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.