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ClinicalTrials.gov 13 recruiting now official registry

Metastatic Triple-Negative Breast Carcinoma clinical trials

13 of 20 indexed Metastatic Triple-Negative Breast Carcinoma trials are currently recruiting.

20 US clinical trials · 13 currently recruiting

Metastatic Triple-Negative Breast Carcinoma is the subject of 20 registered US clinical trials on ClinicalTrials.gov, 13 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 19 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 7 of these trials.

The research picture

Metastatic Triple-Negative Breast Carcinoma has 20 registered US clinical trials, 13 of them open to new participants right now, about 65% of the total.

13
recruiting participants now
65%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
7
top sponsor: National Cancer Institute (NCI)
Phase 110Phase 29

Active & Recent Trials

20 total, page 1 of 1

RECRUITING Phase 2 160 participants

Circulating Tumor DNA to Guide Changes in Standard of Care Chemotherapy

Vanderbilt-Ingram Cancer Center

NCT05770531

RECRUITING 100 participants

Prospective Registry of ADC as First- and Second-line Treatment for Breast Cancer

University of California, San Francisco

NCT06774027

RECRUITING Phase 2 70 participants

Testing the Addition of an Individualized Vaccine to Durvalumab and Tremelimumab and Chemotherapy in Patients With Metastatic Triple Negative Breast Cancer

National Cancer Institute (NCI)

NCT03606967

RECRUITING Phase 2 58 participants

DATO-BASE: DATOpotamab-deruxtecan for Breast Cancer Brain metAstaSEs

Sarah Sammons, MD

NCT06176261

RECRUITING Phase 1 57 participants

Testing the Addition of Anti-Cancer Drug, ZEN003694 (ZEN-3694) and PD-1 Inhibitor (Pembrolizumab), to Standard Chemotherapy (Nab-Paclitaxel) Treatment in Patients With Advanced Triple-Negative Breast Cancer

National Cancer Institute (NCI)

NCT05422794

RECRUITING Phase 1 36 participants

Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer

National Cancer Institute (NCI)

NCT07137416

RECRUITING Phase 1 34 participants

Ivermectin in Combination With Balstilimab or Pembrolizumab in Patients With Metastatic Triple Negative Breast Cancer

Yuan Yuan

NCT05318469

RECRUITING Phase 1 32 participants

Testing the Addition of an Anti-cancer Drug, ASTX727 (Cedazuridine, Decitabine), to Chemotherapy (Paclitaxel) and Immunotherapy (Pembrolizumab) for Metastatic Triple-Negative Breast Cancer

National Cancer Institute (NCI)

NCT05673200

RECRUITING Phase 2 30 participants

Tamoxifen and Pegylated Liposomal Doxorubicin for the Treatment of Patients With Metastatic or Inoperable, Locally Advanced Triple Negative Breast Cancer

Roswell Park Cancer Institute

NCT06434064

RECRUITING Phase 1 30 participants

A Study of Pembrolizumab and Cryoablation in People With Breast Cancer

Memorial Sloan Kettering Cancer Center

NCT06246968

RECRUITING Phase 2 23 participants

Dendritic Cell Vaccines Against Her2/Her3 and Pembrolizumab for the Treatment of Brain Metastasis From Triple Negative Breast Cancer or HER2+ Breast Cancer

Roswell Park Cancer Institute

NCT04348747

RECRUITING Early Phase 1 20 participants

Neratinib in Combination With Ruxolitinib in Patients With mTNBC

Baylor Research Institute

NCT06008275

RECRUITING Phase 2 20 participants

A Cancer Vaccine (STEMVAC) in Combination With Chemotherapy for the Treatment of PD-L1 Negative Metastatic Triple-Negative Breast Cancer

University of Washington

NCT07078604

ACTIVE NOT RECRUITING Phase 1 145 participants

NBTXR3 Activated by Radiotherapy for Patients With Advanced Cancers Treated With An Anti-PD-1 Therapy

Nanobiotix

NCT03589339

ACTIVE NOT RECRUITING Phase 2 122 participants

A Phase 2 Study of Cediranib in Combination With Olaparib in Advanced Solid Tumors

National Cancer Institute (NCI)

NCT02498613

ACTIVE NOT RECRUITING Phase 2 25 participants

INCMGA00012 and Pelareorep for the Treatment of Metastatic Triple Negative Breast Cancer, IRENE Study

Mridula George, MD

NCT04445844

ACTIVE NOT RECRUITING Phase 1 24 participants

Testing the Addition of Copanlisib to Eribulin in Metastatic Triple Negative Breast Cancer

National Cancer Institute (NCI)

NCT04345913

ACTIVE NOT RECRUITING Phase 1 9 participants

CF33-hNIS-antiPDL1 for the Treatment of Metastatic Triple Negative Breast Cancer

City of Hope Medical Center

NCT05081492

ACTIVE NOT RECRUITING Phase 2 8 participants

Estradiol in Treating Patients With ER Beta Positive, Triple Negative Locally Advanced or Metastatic Breast Cancer

Mayo Clinic

NCT03941730

COMPLETED Phase 1 28 participants

Olaparib and Onalespib in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery or Recurrent Ovarian, Fallopian Tube, Primary Peritoneal, or Triple-Negative Breast Cancer

National Cancer Institute (NCI)

NCT02898207

Phase Distribution

PhaseTrial count
Phase 1 10
Phase 2 9

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Triple-Negative Breast Carcinoma Trial Landscape

20 indexed Metastatic Triple-Negative Breast Carcinoma studies · 13 recruiting (65%).

Phase mix: 0 late (III/IV) vs 19 early (I/II).

Top sponsor: National Cancer Institute (NCI) (7 trials), 9 others listed. 20 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Triple-Negative Breast Carcinoma?

PlainTrial tracks 20 US clinical trials for Metastatic Triple-Negative Breast Carcinoma, of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Triple-Negative Breast Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.