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NCT05525507 · ClinicalTrials.gov registry record · Phase 1
Delayed Immunological Tolerance in Patients With Well-functioning Pre-existing HLA-matched Kidney Transplants
A Phase 1 study of Chronic Kidney Diseases and End-Stage Kidney Disease, sponsored by University of California, Los Angeles.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 10
- Enrollment target
- 1
- Study location
NCT05525507 is a Phase 1 study of Chronic Kidney Diseases and End-Stage Kidney Disease that is actively recruiting participants, run by University of California, Los Angeles. The registered enrollment target is 10 participants, below the 445-participant average among 73 other Chronic Kidney Diseases trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state.
The verdict
NCT05525507, a Phase 1 study of Chronic Kidney Diseases and End-Stage Kidney Disease, is actively recruiting participants, sponsored by University of California, Los Angeles.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
The study seeks to determine if patients with a pre-existing, well-functioning kidney transplant from a HLA-identical living donor can be withdrawn from immunosuppressive medications without compromising allograft function through hematopoietic stem cell (HPSC) infusion from the same donor. HPSC infusion will be preceded by a conditioning regimen of total lymphoid irradiation (TLI) and rabbit anti-thymocyte globulin (rATG).
Conditions Studied
Interventions
- COMBINATION_PRODUCT Conditioning and Stem cell infusion
Study Locations (1)
California
- UCLA - Los Angeles
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2022-12-21 |
| Est. Completion | 2026-12 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05525507
The ClinicalTrials.gov registry entry for NCT05525507 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 10 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 445-participant average among 73 other Chronic Kidney Diseases trials with a reported enrollment target (98% lower). The listed sponsor is University of California, Los Angeles, which has 897 total studies on file at ClinicalTrials.gov.
The record links to 4 conditions, with Chronic Kidney Diseases appearing as the primary indexed condition, and to 1 intervention - of which Conditioning and Stem cell infusion is the first listed.
NCT05525507 reports 1 study location spanning 1 distinct geographic area - top geographies include California.
Frequently Asked Questions
What is clinical trial NCT05525507 about?
NCT05525507 is a clinical study titled "Delayed Immunological Tolerance in Patients With Well-functioning Pre-existing HLA-matched Kidney Transplants". The study seeks to determine if patients with a pre-existing, well-functioning kidney transplant from a HLA-identical living donor can be withdrawn from immunosuppressive medications without compromising allograft function through hematopoietic stem cell (HPSC) infusion from the same donor. HPSC inf...
What is the current status of trial NCT05525507?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 10 participants. The study started on 2022-12-21. Estimated completion is 2026-12.
What conditions does trial NCT05525507 study?
This clinical trial studies the following conditions: Chronic Kidney Diseases, End-Stage Kidney Disease, Kidney Transplant Failure and Rejection, Immunological Tolerance.
What interventions are being tested in trial NCT05525507?
The interventions under investigation include: Conditioning and Stem cell infusion (COMBINATION_PRODUCT).
Who is sponsoring clinical trial NCT05525507?
This trial is sponsored by University of California, Los Angeles, which has 897 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05525507 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.