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Pregnancy, High Risk clinical trials
13 of 21 indexed Pregnancy, High Risk trials are currently recruiting.
21 US clinical trials · 13 currently recruiting
Pregnancy, High Risk is the subject of 21 registered US clinical trials on ClinicalTrials.gov, 13 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is Ohio State University, running 5 of these trials.
The research picture
Pregnancy, High Risk has 21 registered US clinical trials, 13 of them open to new participants right now, about 62% of the total.
- 13
- recruiting participants now
- 62%
- of trials open to enrollment
- 6
- in Phase 3–4 (later-stage)
- 5
- top sponsor: Ohio State University
Active & Recent Trials
21 total, page 1 of 1
DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes
Ohio State University
NCT06445946
Commercial or Open Source Closed Loop Impact on Pregnancy Study
University of California, San Francisco
NCT06654713
Intensive Glycemic Targets in Overweight and Obese Women With Gestational Diabetes
Indiana University
NCT05124808
Relugolix Pregnancy Registry: An Observational Study of the Safety of Relugolix-Containing Therapy Exposure in Pregnant Women and Their Offspring
Sumitomo Pharma Switzerland
NCT05739123
T1D Pregnancy & Me
Jaeb Center for Health Research
NCT06959316
Continuous Glucose Monitor Use in Pregnancy
University of Massachusetts, Worcester
NCT05317585
Resources, Inspiration, Support and Empowerment (RISE) for Black Pregnant Women
Cedars-Sinai Medical Center
NCT05552053
Successfully Achieving and Maintaining Euglycemia During Pregnancy for Type 2 Diabetes Through Technology and Coaching
Ohio State University
NCT05662462
A Randomized Controlled Trial of Diabetes Screening Immediately Postpartum (DIP) and Follow Up PP CARE
Ohio State University
NCT05909046
Early Detection of Gestational Diabetes Mellitus in Pregnancy
University of Massachusetts, Worcester
NCT05388643
Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT)
Ohio State University
NCT06396078
Transdermal Patch for BupRenorphine Induction DurinG PrEgnancy (Patch BRIDGE)
Washington University School of Medicine
NCT05790252
Anticoagulation Profile in Pregnant Women Treated With Three Times a Day of Low Molecular Weight Heparin (LMWH)
University of California, Irvine
NCT04861103
MYFEMBREE®: A Retrospective Cohort Study Using an Administrative Healthcare Database to Assess Pregnancy Outcomes in Women Treated With Relugolix Combination Therapy
Sumitomo Pharma Switzerland
NCT05739136
Glycemic Control After Antenatal Corticosteroids in Women With Pregestational and Gestational Diabetes
University of Alabama at Birmingham
NCT04542148
Safer Conception Intervention for HIV-1 Serodiscordant Couples
University of Washington
NCT03030768
Intravenous Insulin vs Subcutaneous Insulin Infusion in Intrapartum Management of Type 1 Diabetes Mellitus
Gianna Wilkie
NCT04599075
Daily Meditation Program in Women Admitted to the Antepartum Unit
The University of Texas Health Science Center, Houston
NCT03737279
Patient Versus Provider-led Titration of Insulin for Glycemic Control in Gestational Diabetes (EMPOWER)
Ohio State University
NCT05922033
MOM NEST Study: Maternal Opioid Medication: Naltrexone Efficacy Study
Boston Medical Center
NCT03718104
A Randomized Placebo Controlled Pilot Study of Probiotic Supplementation in At-risk Pregnant Women
University of Illinois at Chicago
NCT03646487
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 2 |
| Phase 3 | 1 |
| Phase 4 | 5 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Pregnancy, High Risk Trial Landscape
21 indexed Pregnancy, High Risk studies · 13 recruiting (62%).
Phase mix: 6 late (III/IV) vs 2 early (I/II).
Top sponsor: Ohio State University (5 trials), 9 others listed. 21 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Pregnancy, High Risk?
PlainTrial tracks 21 US clinical trials for Pregnancy, High Risk, of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Pregnancy, High Risk?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.