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ClinicalTrials.gov 42 recruiting now official registry

Diabetic Foot Ulcer clinical trials

42 of 68 indexed Diabetic Foot Ulcer trials are currently recruiting.

68 US clinical trials · 42 currently recruiting

Diabetic Foot Ulcer is the subject of 68 registered US clinical trials on ClinicalTrials.gov, 42 of them currently open to new participants. 9 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is Applied Biologics, running 3 of these trials.

The research picture

Diabetic Foot Ulcer has 68 registered US clinical trials, 42 of them open to new participants right now, about 62% of the total.

42
recruiting participants now
62%
of trials open to enrollment
9
in Phase 3–4 (later-stage)
3
top sponsor: Applied Biologics
Phase 12Phase 26Phase 32Phase 47

Active & Recent Trials

68 total, page 2 of 2

COMPLETED NA 202 participants

DermACELL in Subjects With Chronic Wounds of the Lower Extremities

LifeNet Health

NCT01970163

COMPLETED NA 143 participants

Clinical Study Evaluating Symphony™ Versus Standard of Care in the Treatment of Non-Healing Diabetic Foot Ulcers

Aroa Biosurgery Limited

NCT06035536

COMPLETED NA 135 participants

Diabetic Foot Ulcers-Comparing Transforming Powder to Standard of Care

ULURU

NCT05046158

COMPLETED Phase 3 120 participants

VA MERIT: A Comparative Efficacy Study: Treatment of Non-Healing Diabetic

VA Office of Research and Development

NCT01450943

COMPLETED NA 116 participants

AMNIOEXCEL® Plus vs A Marketed Comparator vs SOC in the Management of Diabetic Foot Ulcers

Integra LifeSciences Corporation

NCT03547635

COMPLETED NA 116 participants

Implementation of Telemedicine for Patient With Lower Extremity Wounds

University of California, Davis

NCT04440839

COMPLETED Phase 2 59 participants

Phase 2a Multi-Center Prospective, Randomized Trial to Evaluate the Safety & Efficacy of Topical PEP-TISSEEL for Diabetic Foot Ulcers (DFU)

Rion

NCT06319287

COMPLETED NA 44 participants

Diabetic Foot Ulcer (DFU) Rapid Pathogen Identification

University of Michigan

NCT06569238

COMPLETED NA 40 participants

Evaluation Of An Advanced Borderless Dressing

Smith & Nephew

NCT03146845

COMPLETED Phase 2 34 participants

Comparative Effectiveness of Two Acellular Matrices (Dermacell vs. Integra) for Management of Deep Diabetic Foot Ulcers

Baylor College of Medicine

NCT03476876

COMPLETED NA 29 participants

The Effects of Nutrition Supplementation and Education on the Healing of Diabetic Foot Ulcer (DFU)

Florida State University

NCT04055064

COMPLETED NA 26 participants

Evaluating The Efficacy Of A Keratin Graft In Treating Non-Healing Diabetic Foot Ulcers

ProgenaCare Global

NCT05797285

COMPLETED NA 25 participants

Comparative Study of Amniotic Membrane Wound Graft In the Management of Diabetic Foot Ulcers

MiMedx Group

NCT01552499

COMPLETED NA 24 participants

Clinical Study to Compare Two Skin Substitute Categories for Their Effectiveness to Treat Diabetic Foot Ulcers

Encoll

NCT06557122

COMPLETED 23 participants

Multi Center Site , Controlled Trial Comparing a Bioengineered Skin Substitute to a Human Skin Allograft

Solsys Medical

NCT01676272

COMPLETED Phase 2 15 participants

Topical PluroGel PN for the Treatment of Mildly Infected Diabetic Foot Ulcers

PluroGen Therapeutics

NCT02119754

COMPLETED NA 11 participants

Pilot Study of PHOENIX Wound Matrix® Impact on Chronic DFU Wound Microbiome

RenovoDerm

NCT04437537

COMPLETED NA 10 participants

Evaluating Clinical Acceptance of a NPWT Wound Care System

Medela

NCT03670225

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Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 6
Phase 3 2
Phase 4 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Diabetic Foot Ulcer Trial Landscape

68 indexed Diabetic Foot Ulcer studies · 42 recruiting (62%).

Phase mix: 9 late (III/IV) vs 8 early (I/II).

Top sponsor: Applied Biologics (3 trials), 9 others listed. 18 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Diabetic Foot Ulcer?

PlainTrial tracks 68 US clinical trials for Diabetic Foot Ulcer, of which 42 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Diabetic Foot Ulcer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.