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ClinicalTrials.gov 7 recruiting now official registry

Chronic Rhinosinusitis With Nasal Polyps clinical trials

Every US clinical trial registered for Chronic Rhinosinusitis With Nasal Polyps — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

12 US clinical trials · 7 currently recruiting

The research picture

Chronic Rhinosinusitis With Nasal Polyps has 12 registered US clinical trials, 7 of them open to new participants right now — about 58% of the total.

7
recruiting participants now
58%
of trials open to enrollment
5
in Phase 3–4 (later-stage)
4
top sponsor: Sanofi

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING Phase 3 210 participants

A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps

Sanofi

NCT06834347

RECRUITING Phase 3 210 participants

A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps

Sanofi

NCT06834360

RECRUITING NA 200 participants

3D Printing to Improve Nasal Irrigation Outcome

Ohio State University

NCT06118554

RECRUITING Phase 3 180 participants

A Study to Investigate Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With Tezepelumab

AstraZeneca

NCT06706817

RECRUITING Phase 2 64 participants

Long-term Safety and Efficacy Evaluation of Lunsekimig in Adult Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) Who Completed a Previous Lunsekimig CRSwNP Study

Sanofi

NCT06914908

RECRUITING 60 participants

Dupilumab Treatment Effects in an Ethnically Diverse Population With Chronic Rhinosinusitis With Nasal Polyposis

Montefiore Medical Center

NCT05246267

RECRUITING Early Phase 1 8 participants

The Role of IL5 in Epithelial Cell Integrity

Johns Hopkins University

NCT05895929

ACTIVE NOT RECRUITING Phase 2 79 participants

A Proof-of-concept Study of Lunsekimig Compared With Placebo in Adults With Chronic Rhinosinusitis With Nasal Polyps

Sanofi

NCT06454240

COMPLETED Phase 3 416 participants

Efficacy and Safety of Tezepelumab in Participants With Severe Chronic Rhinosinusitis With Nasal Polyposis

AstraZeneca

NCT04851964

COMPLETED Phase 4 60 participants

Mechanisms of Smell Improvement With Dupilumab.

Medical University of South Carolina

NCT05964465

COMPLETED Phase 1 41 participants

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AMG 282 in Healthy Subjects and Subjects With Chronic Rhinosinusitis With Nasal Polyps

Amgen

NCT02170337

COMPLETED 38 participants

Tissue Immune Interaction in Nasal Polyposis

University of California, San Francis

NCT04628442

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 2
Phase 3 4
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Chronic Rhinosinusitis With Nasal Polyps Trial Landscape

ClinicalTrials.gov lists 12 US studies indexed under Chronic Rhinosinusitis With Nasal Polyps, and 7 of those are currently open to recruitment — roughly 58% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Chronic Rhinosinusitis With Nasal Polyps shows 5 late-stage studies (Phase 3 and Phase 4 combined) alongside 4 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Chronic Rhinosinusitis With Nasal Polyps is led by Sanofi with 4 indexed trials, alongside 7 other organizations in the top contributor list. The list on this page surfaces up to 12 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Chronic Rhinosinusitis With Nasal Polyps?

PlainTrial tracks 12 US clinical trials for Chronic Rhinosinusitis With Nasal Polyps, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Chronic Rhinosinusitis With Nasal Polyps?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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