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RECRUITING Phase 2

Long-term Safety and Efficacy Evaluation of Lunsekimig in Adult Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) Who Completed a Previous Lunsekimig CRSwNP Study

NCT06914908 · View on ClinicalTrials.gov ↗

Study Summary

This is a single-arm extension study to investigate the long-term safety, tolerability, and efficacy of lunsekimig in adult participants with inadequately controlled CRSwNP who have completed a previous lunsekimig CRSwNP clinical study (also referred to as the parent study ACT18207). The study duration will be up to approximately 56 weeks per participant, 52 weeks of treatment period, and 4 weeks of follow-up.

Interventions

  • DRUG Mometasone furoate nasal spray (MFNS)
  • DRUG lunsekimig

Study Locations (20)

Other

  • Investigational Site Number : 0320001 — Buenos Aires
  • Investigational Site Number : 0320003 — Mendoza
  • Investigational Site Number : 0560002 — Ghent
  • Investigational Site Number : 0560001 — Leuven
  • Investigational Site Number : 1000001 — Sofia
  • Investigational Site Number : 8260003 — Manchester
  • Investigational Site Number : 8260001 — Newcastle upon Tyne

Texas

  • McGovern Medical School - UT Physicians Dermatology - Bellaire Station- Site Number : 8400017 — Bellaire
  • Pharmaceutical Research & Consulting- Site Number : 8400004 — Dallas
  • ENT Associates of Texas - McKinne- Site Number : 8400014 — McKinney
  • Alamo ENT Associates- Site Number : 8400001 — San Antonio

California

  • Modena Allergy + Asthma- Site Number : 8400005 — La Jolla

Idaho

  • Treasure Valley Medical Research- Site Number : 8400002 — Boise

Oklahoma

  • Essential Medical Research- Site Number : 8400020 — Tulsa

Santa Fe Province

  • Investigational Site Number : 0320002 — Rosario

Greater Poland Voivodeship

  • Investigational Site Number : 6160004 — Poznan

Lesser Poland Voivodeship

  • Investigational Site Number : 6160002 — Krakow

Trial Details

FieldValue
Enrollment Target 64 participants
Start Date 2025-05-12
Est. Completion 2031-01-29
Phase Phase 2

Sponsor

Sanofi

275 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06914908

The ClinicalTrials.gov registry entry for NCT06914908 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 64 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Sanofi, which has 275 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Chronic Rhinosinusitis With Nasal Polyps appearing as the primary indexed condition, and to 2 interventions — of which Mometasone furoate nasal spray (MFNS) is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06914908 reports 20 study locations spanning 11 distinct geographic areas — top geographies include Other, Texas, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06914908 about?

NCT06914908 is a clinical study titled "Long-term Safety and Efficacy Evaluation of Lunsekimig in Adult Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) Who Completed a Previous Lunsekimig CRSwNP Study". This is a single-arm extension study to investigate the long-term safety, tolerability, and efficacy of lunsekimig in adult participants with inadequately controlled CRSwNP who have completed a previous lunsekimig CRSwNP clinical study (also referred to as the parent study ACT18207). The study dura...

What is the current status of trial NCT06914908?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 64 participants. The study started on 2025-05-12. Estimated completion is 2031-01-29.

What conditions does trial NCT06914908 study?

This clinical trial studies the following conditions: Chronic Rhinosinusitis With Nasal Polyps. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06914908?

The interventions under investigation include: Mometasone furoate nasal spray (MFNS) (DRUG), lunsekimig (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06914908?

This trial is sponsored by Sanofi, which has 275 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06914908 being conducted?

This trial has 20 study locations across California, Idaho, Oklahoma, Texas, Santa Fe Province. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial