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RECRUITING Phase 3

A Study to Investigate Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With Tezepelumab

NCT06706817 · View on ClinicalTrials.gov ↗

Study Summary

The main objective of this study is to evaluate treatment outcomes of tezepelumab among participants with physician-determined surgery-eligible CRSwNP, with or without asthma. Study details include: 1. The study duration will be up to 40 weeks. 2. The treatment duration will be up to 24 weeks. 3. The visit frequency will be once every 4 weeks (Q4W).

Interventions

  • COMBINATION_PRODUCT Tezepelumab

Study Locations (20)

Other

  • Research Site — Plovdiv
  • Research Site — Sofia
  • Research Site — Sofia
  • Research Site — Le Kremlin-Bicêtre
  • Research Site — Lille
  • Research Site — Marseille
  • Research Site — Nantes
  • Research Site — Pierre-Bénite
  • Research Site — Poitiers
  • Research Site — Toulouse
  • Research Site — Düsseldorf
  • Research Site — Marburg
  • Research Site — Tübingen

Quebec

  • Research Site — Québec
  • Research Site — Québec

California

  • Research Site — Newport Beach

Illinois

  • Research Site — Chicago

Massachusetts

  • Research Site — Chestnut Hill

Missouri

  • Research Site — Columbia

Ontario

  • Research Site — Hamilton

Trial Details

FieldValue
Enrollment Target 180 participants
Start Date 2024-12-03
Est. Completion 2027-01-13
Phase Phase 3

Sponsor

AstraZeneca

1,053 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06706817

The ClinicalTrials.gov registry entry for NCT06706817 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 180 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AstraZeneca, which has 1,053 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Chronic Rhinosinusitis With Nasal Polyps appearing as the primary indexed condition, and to 1 intervention — of which Tezepelumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06706817 reports 20 study locations spanning 7 distinct geographic areas — top geographies include Other, Quebec, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06706817 about?

NCT06706817 is a clinical study titled "A Study to Investigate Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With Tezepelumab". The main objective of this study is to evaluate treatment outcomes of tezepelumab among participants with physician-determined surgery-eligible CRSwNP, with or without asthma. Study details include: 1. The study duration will be up to 40 weeks. 2. The treatment duration will be up to 24 weeks. 3. ...

What is the current status of trial NCT06706817?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 180 participants. The study started on 2024-12-03. Estimated completion is 2027-01-13.

What conditions does trial NCT06706817 study?

This clinical trial studies the following conditions: Chronic Rhinosinusitis With Nasal Polyps. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06706817?

The interventions under investigation include: Tezepelumab (COMBINATION_PRODUCT). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06706817?

This trial is sponsored by AstraZeneca, which has 1,053 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06706817 being conducted?

This trial has 20 study locations across California, Illinois, Massachusetts, Missouri, Ontario. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial